ID   A6ZIE4_HUMAN            Unreviewed;       189 AA.
AC   A6ZIE4;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=MUC1 isoform M10 {ECO:0000313|EMBL:ABS01303.1};
DE   SubName: Full=Mucin-1 {ECO:0000313|Ensembl:ENSP00000483473};
GN   Name=MUC1 {ECO:0000313|EMBL:ABS01303.1,
GN   ECO:0000313|Ensembl:ENSP00000483473};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS01303.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483473, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|EMBL:ABS01303.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22941036; DOI=10.1007/s00262-012-1325-2;
RA   Zhang L., Vlad A., Milcarek C., Finn O.J.;
RT   "Human mucin MUC1 RNA undergoes different types of alternative
RT   splicing resulting in multiple isoforms.";
RL   Cancer Immunol. Immunother. 62:423-435(2013).
RN   [3] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000483473}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC234582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF670716; ABS01303.1; -; mRNA.
DR   RefSeq; NP_001191224.1; NM_001204295.1.
DR   UniGene; Hs.89603; -.
DR   SMR; A6ZIE4; -.
DR   MEROPS; S71.001; -.
DR   jPOST; A6ZIE4; -.
DR   PRIDE; A6ZIE4; -.
DR   DNASU; 4582; -.
DR   Ensembl; ENST00000615517; ENSP00000483473; ENSG00000185499.
DR   GeneID; 4582; -.
DR   UCSC; uc009wpl.4; human.
DR   CTD; 4582; -.
DR   EuPathDB; HostDB:ENSG00000185499.16; -.
DR   HGNC; HGNC:7508; MUC1.
DR   OpenTargets; ENSG00000185499; -.
DR   eggNOG; ENOG410IX6R; Eukaryota.
DR   eggNOG; ENOG410ZQ7Z; LUCA.
DR   GeneTree; ENSGT00710000106874; -.
DR   HOGENOM; HOG000290201; -.
DR   HOVERGEN; HBG003075; -.
DR   OrthoDB; 945460at2759; -.
DR   ChiTaRS; MUC1; human.
DR   GenomeRNAi; 4582; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000185499; Expressed in 199 organ(s), highest expression level in body of stomach.
DR   ExpressionAtlas; A6ZIE4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.960; -; 1.
DR   InterPro; IPR036364; SEA_dom_sf.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A6ZIE4,
KW   ECO:0000213|MaxQB:A6ZIE4, ECO:0000213|PeptideAtlas:A6ZIE4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    189       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565778.
FT   TRANSMEM     93    118       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   189 AA;  20037 MW;  C617B22043CAD95A CRC64;
     MTPGTQSPFF LLLLLTVLTA TTAPKPATVV TGSGHASSTP GGEKETSATQ RSSVPSSTEK
     NAFNSSLEDP STDYYQELQR DISEMSGAGV PGWGIALLVL VCVLVALAIV YLIALAVCQC
     RRKNYGQLDI FPARDTYHPM SEYPTYHTHG RYVPPSSTDR SPYEKVSAGN GGSSLSYTNP
     AVAATSANL
//