ID   A6ZIE3_HUMAN            Unreviewed;       213 AA.
AC   A6ZIE3;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=MUC1 isoform M9 {ECO:0000313|EMBL:ABS01302.1};
DE   SubName: Full=Mucin-1 {ECO:0000313|Ensembl:ENSP00000483581};
GN   Name=MUC1 {ECO:0000313|EMBL:ABS01302.1,
GN   ECO:0000313|Ensembl:ENSP00000483581};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS01302.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483581, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|EMBL:ABS01302.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang L., Finn O.J.;
RT   "Isolation of MUC1 isoforms from MCF7 cells.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000483581}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC234582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF670715; ABS01302.1; -; mRNA.
DR   UniGene; Hs.89603; -.
DR   SMR; A6ZIE3; -.
DR   jPOST; A6ZIE3; -.
DR   MaxQB; A6ZIE3; -.
DR   PRIDE; A6ZIE3; -.
DR   Ensembl; ENST00000611577; ENSP00000483581; ENSG00000185499.
DR   UCSC; uc057lms.1; human.
DR   EuPathDB; HostDB:ENSG00000185499.16; -.
DR   HGNC; HGNC:7508; MUC1.
DR   OpenTargets; ENSG00000185499; -.
DR   eggNOG; ENOG410IX6R; Eukaryota.
DR   eggNOG; ENOG410ZQ7Z; LUCA.
DR   GeneTree; ENSGT00710000106874; -.
DR   HOVERGEN; HBG003075; -.
DR   ChiTaRS; MUC1; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000185499; Expressed in 199 organ(s), highest expression level in body of stomach.
DR   ExpressionAtlas; A6ZIE3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A6ZIE3,
KW   ECO:0000213|MaxQB:A6ZIE3, ECO:0000213|PeptideAtlas:A6ZIE3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    213       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565776.
FT   TRANSMEM    117    142       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   213 AA;  21885 MW;  BA957AB00E76AEEB CRC64;
     MTPGTQSPFF LLLLLTVLTG SGHASSTPGG EKETSATQRS SVPSSTEKNA VSMTSSVLSS
     HSPGSGSSTT QGQDVTLAPA TEPASGSAAT WGQDVTSVPV TRPALGSTTP PAGVPGWGIA
     LLVLVCVLVA LAIVYLIALA VCQCRRKNYG QLDIFPARDT YHPMSEYPTY HTHGRYVPPS
     STDRSPYEKV SAGNGGSSLS YTNPAVAATS ANL
//