ID   A6XND0_HUMAN            Unreviewed;       270 AA.
AC   A6XND0;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   13-FEB-2019, entry version 91.
DE   SubName: Full=Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:ABI63364.1, ECO:0000313|Ensembl:ENSP00000477772};
GN   Name=IGFBP3 {ECO:0000313|Ensembl:ENSP00000477772};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI63364.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000477772, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:ABI63364.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yu Z., Zheng Z., Tang T., Fu Y.;
RT   "A computer system platform used to predict novel genes.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000477772}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   EMBL; AC091524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ884397; ABI63364.1; -; mRNA.
DR   UniGene; Hs.450230; -.
DR   jPOST; A6XND0; -.
DR   MaxQB; A6XND0; -.
DR   PRIDE; A6XND0; -.
DR   Ensembl; ENST00000613132; ENSP00000477772; ENSG00000146674.
DR   UCSC; uc064dmi.1; human.
DR   EuPathDB; HostDB:ENSG00000146674.14; -.
DR   HGNC; HGNC:5472; IGFBP3.
DR   OpenTargets; ENSG00000146674; -.
DR   GeneTree; ENSGT00940000158092; -.
DR   HOVERGEN; HBG002631; -.
DR   ChiTaRS; IGFBP3; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000146674; Expressed in 229 organ(s), highest expression level in decidua.
DR   ExpressionAtlas; A6XND0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.800.10; -; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR012211; IGFBP-3.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR009168; IGFBP1-6.
DR   InterPro; IPR022321; IGFBP_1-6_chordata.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR11551; PTHR11551; 1.
DR   PANTHER; PTHR11551:SF3; PTHR11551:SF3; 1.
DR   Pfam; PF00219; IGFBP; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   PRINTS; PR01976; IGFBPFAMILY.
DR   PRINTS; PR01979; IGFBPFAMILY3.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   SUPFAM; SSF57610; SSF57610; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00485231};
KW   Proteomics identification {ECO:0000213|MaxQB:A6XND0,
KW   ECO:0000213|PeptideAtlas:A6XND0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    270       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565765.
FT   DOMAIN       15     96       IGFBP N-terminal.
FT                                {ECO:0000259|PROSITE:PS51323}.
FT   DOMAIN      189    264       Thyroglobulin type-1.
FT                                {ECO:0000259|PROSITE:PS51162}.
SQ   SEQUENCE   270 AA;  29747 MW;  4E36D2E3125B521E CRC64;
     MQRARPTLWA AALTLLVRCE PCDARALAQC APPPAVCAEL VREPGCGCCL TCALSEGQPC
     GIYTERCGSG LRCQPSPDEA RPLQALLDGR GLCVNASAVS RLRAYLLPAP PAPGNASESE
     EDRSAGSVES PSVSSTHRVS DPKFHPLHSK IIIIKKGHAK DSQRYKVDYE SQSTDTQNFS
     SESKRETEYG PCRREMEDTL NHLKFLNVLS PRGVHIPNCD KKGFYKKKQC RPSKGRKRGF
     CWCVDKYGQP LPGYTTKGKE DVHCYSMQSK
//