ID   A6XMV9_HUMAN            Unreviewed;       261 AA.
AC   A6XMV9;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   16-JAN-2019, entry version 81.
DE   SubName: Full=Protease serine 2 preproprotein {ECO:0000313|EMBL:ABI63360.1};
DE   SubName: Full=Trypsin-2 {ECO:0000313|Ensembl:ENSP00000488437};
GN   Name=PRSS2 {ECO:0000313|Ensembl:ENSP00000488437};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI63360.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000488437, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:ABI63360.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yu Z., Zheng Z., Tang T., Fu Y.;
RT   "A computer system platform used to predict novel genes.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000488437}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC245427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ846873; ABI63360.1; -; mRNA.
DR   RefSeq; NP_001290343.1; NM_001303414.1.
DR   UniGene; Hs.449281; -.
DR   UniGene; Hs.726742; -.
DR   UniGene; Hs.728780; -.
DR   jPOST; A6XMV9; -.
DR   PRIDE; A6XMV9; -.
DR   Ensembl; ENST00000633969; ENSP00000488437; ENSG00000275896.
DR   GeneID; 5645; -.
DR   CTD; 5645; -.
DR   EuPathDB; HostDB:ENSG00000275896.4; -.
DR   HGNC; HGNC:9483; PRSS2.
DR   OpenTargets; ENSG00000275896; -.
DR   GeneTree; ENSGT00940000153485; -.
DR   HOVERGEN; HBG013304; -.
DR   OMA; GGQKVPQ; -.
DR   OrthoDB; 1314811at2759; -.
DR   GenomeRNAi; 5645; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000275896; Expressed in 77 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A6XMV9; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|MaxQB:A6XMV9,
KW   ECO:0000213|PeptideAtlas:A6XMV9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    261       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565763.
FT   DOMAIN       24    258       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   261 AA;  28004 MW;  99256B68336AFB97 CRC64;
     MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS
     AGHCYKSAIN SKLSGRGCEY HRIQVRLGEH NIEVLEGNEQ FINAAKIIRH PKYNSRTLDN
     DILLIKLSSP AVINSRVSAI SLPTAPPAAG TESLISGWGN TLSSGADYPD ELQCLDAPVL
     SQAECEASYP GKITNNMFCV GFLEGGKDSC QGDSGGPVVS NGELQGIVSW GYGCAQKNRP
     GVYTKVYNYV DWIKDTIAAN S
//