ID   A6XMH3_HUMAN            Unreviewed;       196 AA.
AC   A6XMH3; E9PF72;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   10-OCT-2018, entry version 82.
DE   SubName: Full=Prolactin {ECO:0000313|EMBL:ABI63353.1, ECO:0000313|Ensembl:ENSP00000478566};
GN   Name=PRL {ECO:0000313|Ensembl:ENSP00000478566};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI63353.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478566, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:ABI63353.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yu Z., Zheng Z., Tang T., Fu Y.;
RT   "A computer system platform used to predict novel genes.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000478566}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
CC       ECO:0000256|SAAS:SAAS00687159}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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DR   EMBL; AL023883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ839492; ABI63353.1; -; mRNA.
DR   UniGene; Hs.1905; -.
DR   UniGene; Hs.735971; -.
DR   SMR; A6XMH3; -.
DR   PRIDE; A6XMH3; -.
DR   Ensembl; ENST00000615510; ENSP00000478566; ENSG00000172179.
DR   UCSC; uc063mdc.1; human.
DR   EuPathDB; HostDB:ENSG00000172179.11; -.
DR   HGNC; HGNC:9445; PRL.
DR   OpenTargets; ENSG00000172179; -.
DR   GeneTree; ENSGT00730000110805; -.
DR   HOGENOM; HOG000264241; -.
DR   HOVERGEN; HBG104895; -.
DR   ChiTaRS; PRL; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000172179; Expressed in 101 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; A6XMH3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00835087};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Proteomics identification {ECO:0000213|MaxQB:A6XMH3,
KW   ECO:0000213|PeptideAtlas:A6XMH3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00119356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    196       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565764.
SQ   SEQUENCE   196 AA;  22624 MW;  62BFD90F3B78BCCD CRC64;
     MNIKGSPWKG SLLLLLVSNL LLSHYIHNLS SEMFSEFDKR YTHGRGFITK AINSCHTSSL
     ATPEDKEQAQ QMNQKDFLSL IVSILRSWNE PLYHLVTEVR GMQEAPEAIL SKAVEIEEQT
     KRLLEGMELI VSQVHPETKE NEIYPVWSGL PSLQMADEES RLSAYYNLLH CLRRDSHKID
     NYLKLLKCRI IHNNNC
//