ID   A6XGL2_HUMAN            Unreviewed;        98 AA.
AC   A6XGL2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   16-JAN-2019, entry version 103.
DE   RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
GN   Name=INS {ECO:0000313|Ensembl:ENSP00000424008};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI63346.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424008, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|EMBL:ABI63346.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yu Z., Zheng Z., Tang T., Fu Y.;
RT   "A computer system platform used to predict novel genes.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000424008}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It
CC       increases cell permeability to monosaccharides, amino acids and
CC       fatty acids. It accelerates glycolysis, the pentose phosphate
CC       cycle, and glycogen synthesis in liver.
CC       {ECO:0000256|RuleBase:RU000406, ECO:0000256|SAAS:SAAS00017993}.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000256|RuleBase:RU000406,
CC       ECO:0000256|SAAS:SAAS00346740}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406,
CC       ECO:0000256|SAAS:SAAS00822014}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|RuleBase:RU000406, ECO:0000256|SAAS:SAAS00542063}.
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DR   EMBL; AC132217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ778082; ABI63346.1; -; mRNA.
DR   UniGene; Hs.272259; -.
DR   SMR; A6XGL2; -.
DR   Allergome; 2121; Hom s Insulin.
DR   EPD; A6XGL2; -.
DR   jPOST; A6XGL2; -.
DR   PeptideAtlas; A6XGL2; -.
DR   PRIDE; A6XGL2; -.
DR   Ensembl; ENST00000512523; ENSP00000424008; ENSG00000254647.
DR   UCSC; uc009ydg.2; human.
DR   EuPathDB; HostDB:ENSG00000254647.6; -.
DR   HGNC; HGNC:6081; INS.
DR   OpenTargets; ENSG00000254647; -.
DR   eggNOG; ENOG410IZ9B; Eukaryota.
DR   eggNOG; ENOG41115QQ; LUCA.
DR   GeneTree; ENSGT00390000015440; -.
DR   HOGENOM; HOG000261669; -.
DR   HOVERGEN; HBG006137; -.
DR   OrthoDB; 133009at2759; -.
DR   ChiTaRS; INS; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000254647; Expressed in 72 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; A6XGL2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU000406,
KW   ECO:0000256|SAAS:SAAS00018017};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01052213};
KW   Glucose metabolism {ECO:0000256|RuleBase:RU000406,
KW   ECO:0000256|SAAS:SAAS00018017};
KW   Hormone {ECO:0000256|RuleBase:RU000406,
KW   ECO:0000256|SAAS:SAAS00017990};
KW   Proteomics identification {ECO:0000213|MaxQB:A6XGL2,
KW   ECO:0000213|PeptideAtlas:A6XGL2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU000406,
KW   ECO:0000256|SAAS:SAAS00822033}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     98       Insulin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014084004.
FT   DOMAIN       28     97       IlGF. {ECO:0000259|SMART:SM00078}.
SQ   SEQUENCE   98 AA;  10959 MW;  6DDEDC02ED1A9CB9 CRC64;
     MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
     LQGSLQPLAL EGSLQKRGIV EQCCTSICSL YQLENYCN
//