ID   DRS7C_HUMAN             Reviewed;         312 AA.
AC   A6NNS2; B7ZW74; B9EJH3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   13-FEB-2019, entry version 95.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7C;
DE            EC=1.1.-.-;
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 2 {ECO:0000303|PubMed:19027726};
DE   Flags: Precursor;
GN   Name=DHRS7C; Synonyms=SDR32C2 {ECO:0000303|PubMed:19027726};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA   Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA   Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA   Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M.,
RA   Thornton J.M., Adamski J., Oppermann U.;
RT   "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT   nomenclature initiative.";
RL   Chem. Biol. Interact. 178:94-98(2009).
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6NNS2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NNS2-2; Sequence=VSP_054852;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI47025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC       Sequence=AAI47026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR   EMBL; AC027045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC147024; AAI47025.1; ALT_INIT; mRNA.
DR   EMBL; BC147025; AAI47026.1; ALT_INIT; mRNA.
DR   EMBL; BC171909; AAI71909.1; -; mRNA.
DR   CCDS; CCDS56020.1; -. [A6NNS2-1]
DR   CCDS; CCDS58517.1; -. [A6NNS2-2]
DR   RefSeq; NP_001099041.1; NM_001105571.2. [A6NNS2-2]
DR   RefSeq; NP_001207422.1; NM_001220493.1. [A6NNS2-1]
DR   UniGene; Hs.61684; -.
DR   ProteinModelPortal; A6NNS2; -.
DR   BioGrid; 128363; 1.
DR   STRING; 9606.ENSP00000327975; -.
DR   iPTMnet; A6NNS2; -.
DR   PhosphoSitePlus; A6NNS2; -.
DR   BioMuta; DHRS7C; -.
DR   PaxDb; A6NNS2; -.
DR   PRIDE; A6NNS2; -.
DR   ProteomicsDB; 1633; -.
DR   Ensembl; ENST00000330255; ENSP00000327975; ENSG00000184544. [A6NNS2-1]
DR   Ensembl; ENST00000571134; ENSP00000459579; ENSG00000184544. [A6NNS2-2]
DR   GeneID; 201140; -.
DR   KEGG; hsa:201140; -.
DR   UCSC; uc010cof.4; human. [A6NNS2-1]
DR   CTD; 201140; -.
DR   DisGeNET; 201140; -.
DR   EuPathDB; HostDB:ENSG00000184544.11; -.
DR   GeneCards; DHRS7C; -.
DR   HGNC; HGNC:32423; DHRS7C.
DR   MIM; 616161; gene.
DR   neXtProt; NX_A6NNS2; -.
DR   OpenTargets; ENSG00000184544; -.
DR   eggNOG; KOG1205; Eukaryota.
DR   eggNOG; COG1028; LUCA.
DR   GeneTree; ENSGT00940000157100; -.
DR   HOVERGEN; HBG107825; -.
DR   InParanoid; A6NNS2; -.
DR   KO; K11167; -.
DR   OMA; DISCVQD; -.
DR   OrthoDB; 1313182at2759; -.
DR   PhylomeDB; A6NNS2; -.
DR   TreeFam; TF313474; -.
DR   GenomeRNAi; 201140; -.
DR   PRO; PR:A6NNS2; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000184544; Expressed in 81 organ(s), highest expression level in deltoid.
DR   ExpressionAtlas; A6NNS2; baseline and differential.
DR   Genevisible; A6NNS2; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0014801; C:longitudinal sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0004745; F:retinol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; NAD; NADP; Oxidoreductase;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    312       Dehydrogenase/reductase SDR family member
FT                                7C.
FT                                /FTId=PRO_0000333755.
FT   NP_BIND      41     65       NAD or NADP. {ECO:0000250}.
FT   ACT_SITE    192    192       Proton acceptor. {ECO:0000255|PROSITE-
FT                                ProRule:PRU10001}.
FT   VAR_SEQ      90     90       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_054852.
FT   VARIANT     227    227       S -> L (in dbSNP:rs2280490).
FT                                /FTId=VAR_043150.
SQ   SEQUENCE   312 AA;  34878 MW;  ADCE06D480B40E00 CRC64;
     MGVMAMLMLP LLLLGISGLL FIYQEVSRLW SKSAVQNKVV VITDAISGLG KECARVFHTG
     GARLVLCGKN WERLENLYDA LISVADPSKQ TFTPKLVLLD LSDISCVPDV AKEVLDCYGC
     VDILINNASV KVKGPAHKIS LELDKKIMDA NYFGPITLTK ALLPNMISRR TGQIVLVNNI
     QGKFGIPFRT TYAASKHAAL GFFDCLRAEV EEYDVVISTV SPTFIRSYHV YPEQGNWEAS
     IWKFFFRKLT YGVHPVEVAE EVMRTVRRKK QEVFMANPIP KAAVYVRTFF PEFFFAVVAC
     GVKEKLNVPE EG
//