ID   A6NNA4_HUMAN            Unreviewed;       499 AA.
AC   A6NNA4;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 2.
DT   16-JAN-2019, entry version 92.
DE   SubName: Full=Matrilin-4 {ECO:0000313|Ensembl:ENSP00000243983};
GN   Name=MATN4 {ECO:0000313|Ensembl:ENSP00000243983};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000243983, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000243983, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000243983}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL021578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_085095.1; NM_030592.3.
DR   UniGene; Hs.278489; -.
DR   ProteinModelPortal; A6NNA4; -.
DR   EPD; A6NNA4; -.
DR   jPOST; A6NNA4; -.
DR   PeptideAtlas; A6NNA4; -.
DR   PRIDE; A6NNA4; -.
DR   Ensembl; ENST00000353917; ENSP00000243983; ENSG00000124159.
DR   GeneID; 8785; -.
DR   UCSC; uc061xhe.1; human.
DR   CTD; 8785; -.
DR   EuPathDB; HostDB:ENSG00000124159.15; -.
DR   HGNC; HGNC:6910; MATN4.
DR   OpenTargets; ENSG00000124159; -.
DR   PharmGKB; PA30653; -.
DR   GeneTree; ENSGT00940000157086; -.
DR   HOGENOM; HOG000263415; -.
DR   HOVERGEN; HBG056906; -.
DR   OrthoDB; 1174178at2759; -.
DR   GenomeRNAi; 8785; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000124159; Expressed in 89 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A6NNA4; baseline and differential.
DR   Genevisible; A6NNA4; HS.
DR   Gene3D; 1.20.5.30; -; 1.
DR   Gene3D; 3.40.50.410; -; 2.
DR   InterPro; IPR034306; Matrilin-4.
DR   InterPro; IPR036337; Matrilin_cc_sf.
DR   InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR45365; PTHR45365; 2.
DR   Pfam; PF10393; Matrilin_ccoil; 1.
DR   Pfam; PF00092; VWA; 2.
DR   SMART; SM01279; Matrilin_ccoil; 1.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; SSF53300; 2.
DR   SUPFAM; SSF58002; SSF58002; 1.
DR   PROSITE; PS50234; VWFA; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A6NNA4,
KW   ECO:0000213|PeptideAtlas:A6NNA4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    499       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005660229.
FT   DOMAIN       34    213       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      263    438       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   COILED      474    494       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   499 AA;  55117 MW;  DE7595B2585F6E93 CRC64;
     MRGLLCWPVL LLLLQPWETQ LQLTGPRCHT GPLDLVFVID SSRSVRPFEF ETMRQFLMGL
     LRGLNVGPNA TRVGVIQYSS QVQSVFPLRA FSRREDMERA IRDLVPLAQG TMTGLAIQYA
     MNVAFSVAEG ARPPEERVPR VAVIVTDGRP QDRVAEVAAQ ARARGIEIYA VGVQRADVGS
     LRAMASPPLD EHVFLVESFD LIQEFGLQFQ SRLCVRDLCN GVDHGCEFQC VSEGLSYRCL
     CPEGRQLQAD GKSCNRCREG HVDLVLLVDG SKSVRPQNFE LVKRFVNQIV DFLDVSPEGT
     RVGLVQFSSR VRTEFPLGRY GTAAEVKQAV LAVEYMERGT MTGLALRHMV EHSFSEAQGA
     RPRALNVPRV GLVFTDGRSQ DDISVWAARA KEEGIVMYAV GVGKAVEAEL REIASEPAEL
     HVSYAPDFGT MTHLLENLRG SICPEEGISA GTELRSPCEC ESLVEFQGRT LGALESLTLN
     LAQLTARLED LENQLANQK
//