ID   L37A1_HUMAN             Reviewed;        1700 AA.
AC   A6NMS7; Q68DY2; Q8IWC7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 3.
DT   13-FEB-2019, entry version 100.
DE   RecName: Full=Leucine-rich repeat-containing protein 37A;
DE   Flags: Precursor;
GN   Name=LRRC37A; Synonyms=LRRC37A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH18088.1; Type=Frameshift; Positions=8, 177; Evidence={ECO:0000305};
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DR   EMBL; CR749232; CAH18088.1; ALT_FRAME; mRNA.
DR   EMBL; AC005829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC040501; AAH40501.2; -; mRNA.
DR   CCDS; CCDS11504.2; -.
DR   RefSeq; NP_055649.4; NM_014834.4.
DR   UniGene; Hs.579108; -.
DR   UniGene; Hs.744157; -.
DR   UniGene; Hs.744758; -.
DR   ProteinModelPortal; A6NMS7; -.
DR   IntAct; A6NMS7; 1.
DR   STRING; 9606.ENSP00000326324; -.
DR   iPTMnet; A6NMS7; -.
DR   PhosphoSitePlus; A6NMS7; -.
DR   BioMuta; LRRC37A; -.
DR   jPOST; A6NMS7; -.
DR   PaxDb; A6NMS7; -.
DR   PRIDE; A6NMS7; -.
DR   ProteomicsDB; 1558; -.
DR   Ensembl; ENST00000320254; ENSP00000326324; ENSG00000176681.
DR   GeneID; 9884; -.
DR   KEGG; hsa:9884; -.
DR   UCSC; uc002ikg.3; human.
DR   CTD; 9884; -.
DR   DisGeNET; 9884; -.
DR   EuPathDB; HostDB:ENSG00000176681.14; -.
DR   GeneCards; LRRC37A; -.
DR   H-InvDB; HIX0013912; -.
DR   H-InvDB; HIX0027330; -.
DR   H-InvDB; HIX0039350; -.
DR   H-InvDB; HIX0173525; -.
DR   H-InvDB; HIX0173724; -.
DR   H-InvDB; HIX0174144; -.
DR   H-InvDB; HIX0174145; -.
DR   H-InvDB; HIX0174159; -.
DR   H-InvDB; HIX0202473; -.
DR   HGNC; HGNC:29069; LRRC37A.
DR   HPA; HPA042121; -.
DR   HPA; HPA042701; -.
DR   HPA; HPA043056; -.
DR   HPA; HPA045090; -.
DR   HPA; HPA049080; -.
DR   MIM; 616555; gene.
DR   neXtProt; NX_A6NMS7; -.
DR   OpenTargets; ENSG00000176681; -.
DR   eggNOG; ENOG410IJNR; Eukaryota.
DR   eggNOG; ENOG410YV94; LUCA.
DR   GeneTree; ENSGT00530000063282; -.
DR   HOGENOM; HOG000113269; -.
DR   HOVERGEN; HBG100009; -.
DR   InParanoid; A6NMS7; -.
DR   OMA; PINQEGT; -.
DR   OrthoDB; 181606at2759; -.
DR   PhylomeDB; A6NMS7; -.
DR   TreeFam; TF341959; -.
DR   ChiTaRS; LRRC37A; human.
DR   GeneWiki; LRRC37A; -.
DR   GenomeRNAi; 9884; -.
DR   PRO; PR:A6NMS7; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000176681; Expressed in 85 organ(s), highest expression level in testis.
DR   ExpressionAtlas; A6NMS7; baseline and differential.
DR   Genevisible; A6NMS7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   InterPro; IPR029423; LRRC37AB_C.
DR   PANTHER; PTHR23045; PTHR23045; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 7.
DR   Pfam; PF14914; LRRC37AB_C; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     35       {ECO:0000255}.
FT   CHAIN        36   1700       Leucine-rich repeat-containing protein
FT                                37A.
FT                                /FTId=PRO_0000337079.
FT   TOPO_DOM     36   1582       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1583   1603       Helical. {ECO:0000255}.
FT   TOPO_DOM   1604   1700       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      866    887       LRR 1.
FT   REPEAT      890    911       LRR 2.
FT   REPEAT      914    935       LRR 3.
FT   REPEAT      938    959       LRR 4.
FT   REPEAT      965    986       LRR 5.
FT   CARBOHYD    296    296       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1079   1079       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT     58     58       E -> D (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    349    349       P -> S (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    370    370       P -> S (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    377    377       P -> L (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    406    406       A -> D (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    440    440       T -> A (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    552    552       T -> I (in Ref. 1; CAH18088).
FT                                {ECO:0000305}.
FT   CONFLICT    558    558       K -> M (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    630    630       P -> A (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    776    776       R -> H (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT    785    785       R -> Q (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT   1255   1255       T -> A (in Ref. 1; CAH18088 and 3;
FT                                AAH40501). {ECO:0000305}.
FT   CONFLICT   1288   1288       R -> G (in Ref. 1; CAH18088).
FT                                {ECO:0000305}.
FT   CONFLICT   1384   1384       E -> G (in Ref. 3; AAH40501).
FT                                {ECO:0000305}.
FT   CONFLICT   1693   1693       E -> G (in Ref. 3; AAH40501).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1700 AA;  188258 MW;  F5DBA6389568D792 CRC64;
     MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPESW
     SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
     LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
     QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
     EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
     PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
     QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
     IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
     QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
     QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
     PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
     ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
     LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
     QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
     LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
     LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
     HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
     PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
     TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
     FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
     AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGTPSTSS
     PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTTK
     VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSALSE
     HFIEKNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
     TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
     LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
     EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
     GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDLYKPLSAT RINNHAWKLH KKSSNEDKIL
     NRDPGDSEAP TEEEESEALP
//