ID   A6NMH8_HUMAN            Unreviewed;       274 AA.
AC   A6NMH8;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   13-FEB-2019, entry version 83.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=CD81 {ECO:0000313|Ensembl:ENSP00000370424};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000370424, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000370424, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000370424}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS00545671}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361218}.
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DR   EMBL; AC124057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC129929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A6NMH8; -.
DR   SwissPalm; A6NMH8; -.
DR   EPD; A6NMH8; -.
DR   jPOST; A6NMH8; -.
DR   MaxQB; A6NMH8; -.
DR   PeptideAtlas; A6NMH8; -.
DR   PRIDE; A6NMH8; -.
DR   Ensembl; ENST00000381036; ENSP00000370424; ENSG00000110651.
DR   UCSC; uc057xxr.1; human.
DR   EuPathDB; HostDB:ENSG00000110651.11; -.
DR   HGNC; HGNC:1701; CD81.
DR   OpenTargets; ENSG00000110651; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000158805; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG002324; -.
DR   OMA; FEMIFSM; -.
DR   PhylomeDB; A6NMH8; -.
DR   ChiTaRS; CD81; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110651; Expressed in 231 organ(s), highest expression level in myometrium.
DR   ExpressionAtlas; A6NMH8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005};
KW   Proteomics identification {ECO:0000213|EPD:A6NMH8,
KW   ECO:0000213|MaxQB:A6NMH8, ECO:0000213|PeptideAtlas:A6NMH8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    274       Tetraspanin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002700227.
FT   TRANSMEM     96    122       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    128    152       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    240    264       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   274 AA;  29806 MW;  BF7B42F41D991429 CRC64;
     MWCGWSFSWQ PVHWVRSACG CSLTWVSWSL ASSSSRSLLK VGELGMAPFV HARAGKTKAQ
     LAGGVILGVA LWLRHDPQTT NLLYLELGDK PAPNTFYVGI YILIAVGAVM MFVGFLGCYG
     AIQESQCLLG TFFTCLVILF ACEVAAGIWG FVNKDQIAKD VKQFYDQALQ QAVVDDDANN
     AKAVVKTFHE TLDCCGSSTL TALTTSVLKN NLCPSGSNII SNLFKEDCHQ KIDDLFSGKL
     YLIGIAAIVV AVIMIFEMIL SMVLCCGIRN SSVY
//