ID   L37A2_HUMAN             Reviewed;        1700 AA.
AC   A6NM11; B7ZMC3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   13-FEB-2019, entry version 94.
DE   RecName: Full=Leucine-rich repeat-containing protein 37A2;
DE   Flags: Precursor;
GN   Name=LRRC37A2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1700, AND VARIANTS
RP   LEU-1141; THR-1281; LYS-1385 AND PRO-1423.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
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DR   EMBL; AC138645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC144427; AAI44428.1; -; mRNA.
DR   CCDS; CCDS42353.1; -.
DR   RefSeq; NP_001006608.2; NM_001006607.2.
DR   UniGene; Hs.646568; -.
DR   UniGene; Hs.744157; -.
DR   UniGene; Hs.744758; -.
DR   ProteinModelPortal; A6NM11; -.
DR   IntAct; A6NM11; 4.
DR   STRING; 9606.ENSP00000333071; -.
DR   iPTMnet; A6NM11; -.
DR   PhosphoSitePlus; A6NM11; -.
DR   BioMuta; LRRC37A2; -.
DR   EPD; A6NM11; -.
DR   jPOST; A6NM11; -.
DR   PaxDb; A6NM11; -.
DR   PRIDE; A6NM11; -.
DR   ProteomicsDB; 1505; -.
DR   Ensembl; ENST00000333412; ENSP00000333071; ENSG00000238083.
DR   Ensembl; ENST00000576629; ENSP00000459551; ENSG00000238083.
DR   GeneID; 474170; -.
DR   KEGG; hsa:474170; -.
DR   UCSC; uc002ikn.2; human.
DR   CTD; 474170; -.
DR   DisGeNET; 474170; -.
DR   EuPathDB; HostDB:ENSG00000238083.7; -.
DR   GeneCards; LRRC37A2; -.
DR   HGNC; HGNC:32404; LRRC37A2.
DR   HPA; HPA042121; -.
DR   HPA; HPA042701; -.
DR   HPA; HPA043056; -.
DR   HPA; HPA045090; -.
DR   HPA; HPA049080; -.
DR   MIM; 616556; gene.
DR   neXtProt; NX_A6NM11; -.
DR   PharmGKB; PA162394530; -.
DR   eggNOG; ENOG410IJNR; Eukaryota.
DR   eggNOG; ENOG410YV94; LUCA.
DR   GeneTree; ENSGT00530000063282; -.
DR   HOGENOM; HOG000113269; -.
DR   HOVERGEN; HBG059675; -.
DR   InParanoid; A6NM11; -.
DR   OMA; SANICEL; -.
DR   OrthoDB; 181606at2759; -.
DR   PhylomeDB; A6NM11; -.
DR   TreeFam; TF341959; -.
DR   ChiTaRS; LRRC37A2; human.
DR   GenomeRNAi; 474170; -.
DR   PRO; PR:A6NM11; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000238083; Expressed in 89 organ(s), highest expression level in myometrium.
DR   Genevisible; A6NM11; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   InterPro; IPR029423; LRRC37AB_C.
DR   PANTHER; PTHR23045; PTHR23045; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 6.
DR   Pfam; PF14914; LRRC37AB_C; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Polymorphism; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     35       {ECO:0000255}.
FT   CHAIN        36   1700       Leucine-rich repeat-containing protein
FT                                37A2.
FT                                /FTId=PRO_0000337080.
FT   TOPO_DOM     36   1582       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1583   1603       Helical. {ECO:0000255}.
FT   TOPO_DOM   1604   1700       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      137    160       LRR 1.
FT   REPEAT      230    253       LRR 2.
FT   REPEAT      267    290       LRR 3.
FT   REPEAT      864    887       LRR 4.
FT   REPEAT      888    911       LRR 5.
FT   REPEAT      912    935       LRR 6.
FT   REPEAT      937    959       LRR 7.
FT   REPEAT      963    987       LRR 8.
FT   REPEAT     1002   1027       LRR 9.
FT   REPEAT     1124   1146       LRR 10.
FT   CARBOHYD    296    296       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1079   1079       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT    1141   1141       F -> L (in dbSNP:rs1863115).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_070799.
FT   VARIANT    1281   1281       I -> T (in dbSNP:rs62073349).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_070800.
FT   VARIANT    1385   1385       N -> K (in dbSNP:rs1969205).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_070801.
FT   VARIANT    1423   1423       H -> P (in dbSNP:rs201103889).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_070802.
FT   CONFLICT   1508   1508       A -> T (in Ref. 2; AAI44428).
FT                                {ECO:0000305}.
FT   CONFLICT   1628   1628       W -> R (in Ref. 2; AAI44428).
FT                                {ECO:0000305}.
FT   CONFLICT   1686   1687       Missing (in Ref. 2; AAI44428).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1700 AA;  188393 MW;  B80368373F772CDF CRC64;
     MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPDSW
     SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
     LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
     QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
     EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
     PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
     QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
     IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
     QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
     QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
     PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
     ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
     LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETRHSTALE KTTAPRPDRV
     QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
     LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
     LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
     HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
     PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
     TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
     FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
     AEEKRLGSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
     PAKALPQVRD RWKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTPK
     VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSAPSE
     HFIENNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPHEADSAGT AFNLGPTVKQ
     TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
     LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
     EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
     GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDMYKPLSAT RINNHAWKLH KKSSNEDKIL
     NRDPGDSEAP TEEEESEALP
//