ID   VTM2B_HUMAN             Reviewed;         285 AA.
AC   A6NLU5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   13-FEB-2019, entry version 88.
DE   RecName: Full=V-set and transmembrane domain-containing protein 2B;
DE   Flags: Precursor;
GN   Name=VSTM2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AC011474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46034.1; -.
DR   RefSeq; NP_001139811.1; NM_001146339.1.
DR   RefSeq; XP_011525204.1; XM_011526902.2.
DR   UniGene; Hs.451618; -.
DR   ProteinModelPortal; A6NLU5; -.
DR   IntAct; A6NLU5; 1.
DR   iPTMnet; A6NLU5; -.
DR   PhosphoSitePlus; A6NLU5; -.
DR   BioMuta; VSTM2B; -.
DR   PaxDb; A6NLU5; -.
DR   PRIDE; A6NLU5; -.
DR   ProteomicsDB; 1493; -.
DR   Ensembl; ENST00000335523; ENSP00000335038; ENSG00000187135.
DR   GeneID; 342865; -.
DR   KEGG; hsa:342865; -.
DR   UCSC; uc010xrl.2; human.
DR   CTD; 342865; -.
DR   EuPathDB; HostDB:ENSG00000187135.7; -.
DR   GeneCards; VSTM2B; -.
DR   HGNC; HGNC:33595; VSTM2B.
DR   neXtProt; NX_A6NLU5; -.
DR   OpenTargets; ENSG00000187135; -.
DR   PharmGKB; PA162408890; -.
DR   eggNOG; ENOG410IKGK; Eukaryota.
DR   eggNOG; ENOG4111HPI; LUCA.
DR   GeneTree; ENSGT00940000161356; -.
DR   HOGENOM; HOG000253955; -.
DR   HOVERGEN; HBG052093; -.
DR   InParanoid; A6NLU5; -.
DR   OMA; VEMPCAF; -.
DR   OrthoDB; 1216208at2759; -.
DR   PhylomeDB; A6NLU5; -.
DR   TreeFam; TF331739; -.
DR   GenomeRNAi; 342865; -.
DR   PRO; PR:A6NLU5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000187135; Expressed in 43 organ(s), highest expression level in substantia nigra.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     28       {ECO:0000255}.
FT   CHAIN        29    285       V-set and transmembrane domain-containing
FT                                protein 2B.
FT                                /FTId=PRO_0000319943.
FT   TOPO_DOM     29    263       Extracellular. {ECO:0000255}.
FT   TRANSMEM    264    284       Helical. {ECO:0000255}.
FT   TOPO_DOM    285    285       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       29    143       Ig-like V-type.
FT   DISULFID     49    127       {ECO:0000255|PROSITE-ProRule:PRU00114}.
SQ   SEQUENCE   285 AA;  30297 MW;  B21B2FF41E3DC320 CRC64;
     MEQRNRLGAL GYLPPLLLHA LLLFVADAAF TEVPKDVTVR EGDDIEMPCA FRASGATSYS
     LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST VRVQGNDISH RLRLSAVRLQ
     DEGVYECRVS DYSDDDTQEH KAQAMLRVLS RFAPPNMQAA EAVSHIQSSG PRRHGPASAA
     NANNAGAASR TTSEPGRGDK SPPPGSPPAA IDPAVPEAAA ASAAHTPTTT VAAAAAASSA
     SPPSGQAVLL RQRHGSGTGR SYTTDPLLSL LLLALHKFLR LLLGH
//