ID   SHSA7_HUMAN             Reviewed;         538 AA.
AC   A6NL88;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 3.
DT   16-JAN-2019, entry version 82.
DE   RecName: Full=Protein shisa-7 {ECO:0000305};
DE   AltName: Full=Protein shisa-6-like;
DE   Flags: Precursor;
GN   Name=SHISA7 {ECO:0000312|HGNC:HGNC:35409};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-362.
RA   Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT   "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT   human.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of long-term synaptic potentiation
CC       specifically involved in the formation and retrieval of
CC       hippocampus-dependent contextual fear memory. Probably regulates
CC       induction and maintenance of long-term potentiation at Schaffer
CC       collaterals/CA3-CA1 excitatory synapses by affecting the
CC       recruitment of AMPA-type glutamate receptor (AMPAR) at
CC       postsynaptic density. {ECO:0000250|UniProtKB:Q8C3Q5}.
CC   -!- SUBUNIT: Component of the postsynaptic hippocampal AMPA-type
CC       glutamate receptor (AMPAR) complex, at least composed of pore
CC       forming AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary
CC       proteins SHISA6 and SHISA7. Interacts (via PDZ-binding motif) with
CC       DLG4/PSD-95 (via PDZ domain); the interaction is direct.
CC       {ECO:0000250|UniProtKB:Q8C3Q5}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane, postsynaptic density {ECO:0000250|UniProtKB:Q8C3Q5};
CC       Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q8C3Q5}.
CC   -!- DOMAIN: The PDZ-binding motif interacts with PDZ-domain of
CC       scaffolding protein DLG4. {ECO:0000250|UniProtKB:Q8C3Q5}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; AC135592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DY654595; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DY654596; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DY654895; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DY654896; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS46193.1; -.
DR   RefSeq; NP_001138648.1; NM_001145176.1.
DR   UniGene; Hs.6664; -.
DR   ProteinModelPortal; A6NL88; -.
DR   SMR; A6NL88; -.
DR   STRING; 9606.ENSP00000365503; -.
DR   iPTMnet; A6NL88; -.
DR   PhosphoSitePlus; A6NL88; -.
DR   BioMuta; SHISA7; -.
DR   jPOST; A6NL88; -.
DR   PaxDb; A6NL88; -.
DR   PRIDE; A6NL88; -.
DR   ProteomicsDB; 1458; -.
DR   TopDownProteomics; A6NL88; -.
DR   Ensembl; ENST00000376325; ENSP00000365503; ENSG00000187902.
DR   GeneID; 729956; -.
DR   KEGG; hsa:729956; -.
DR   UCSC; uc002qkz.4; human.
DR   CTD; 729956; -.
DR   EuPathDB; HostDB:ENSG00000187902.11; -.
DR   GeneCards; SHISA7; -.
DR   HGNC; HGNC:35409; SHISA7.
DR   HPA; HPA058935; -.
DR   MIM; 617328; gene.
DR   neXtProt; NX_A6NL88; -.
DR   OpenTargets; ENSG00000187902; -.
DR   PharmGKB; PA165394299; -.
DR   eggNOG; ENOG410IVHW; Eukaryota.
DR   eggNOG; ENOG410ZRPZ; LUCA.
DR   GeneTree; ENSGT00940000162254; -.
DR   HOGENOM; HOG000154745; -.
DR   HOVERGEN; HBG108632; -.
DR   InParanoid; A6NL88; -.
DR   OMA; QYYKAMM; -.
DR   OrthoDB; 475894at2759; -.
DR   PhylomeDB; A6NL88; -.
DR   TreeFam; TF330800; -.
DR   GenomeRNAi; 729956; -.
DR   PRO; PR:A6NL88; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000187902; Expressed in 70 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A6NL88; baseline and differential.
DR   Genevisible; A6NL88; HS.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0098985; C:asymmetric, glutamatergic, excitatory synapse; ISS:UniProtKB.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0032591; C:dendritic spine membrane; IBA:GO_Central.
DR   GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0035255; F:ionotropic glutamate receptor binding; ISS:UniProtKB.
DR   GO; GO:0007613; P:memory; ISS:UniProtKB.
DR   GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; ISS:UniProtKB.
DR   GO; GO:1904717; P:regulation of AMPA glutamate receptor clustering; ISS:UniProtKB.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; IEA:Ensembl.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IBA:GO_Central.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774; PTHR31774; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Complete proteome; Glycoprotein;
KW   Membrane; Phosphoprotein; Postsynaptic cell membrane;
KW   Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    538       Protein shisa-7.
FT                                /FTId=PRO_0000344472.
FT   TOPO_DOM     20    186       Extracellular. {ECO:0000255}.
FT   TRANSMEM    187    207       Helical. {ECO:0000255}.
FT   TOPO_DOM    208    538       Cytoplasmic. {ECO:0000255}.
FT   MOTIF       535    538       PDZ-binding.
FT                                {ECO:0000250|UniProtKB:Q8C3Q5}.
FT   COMPBIAS    145    183       Gly-rich.
FT   MOD_RES     417    417       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q8C3Q5}.
FT   MOD_RES     512    512       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:Q8C3Q5}.
FT   CARBOHYD     23     23       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     59     59       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   538 AA;  56214 MW;  B64A8A543C64CF6B CRC64;
     MPALLLLVLL ASSAGQARAR PSNATSAEPA GPLPALLAHL RRLTGALTGG GGAASPGANG
     TRTGPAGGAG AAARAPPPAE LCHGYYDVMG QYDATFNCST GSYRFCCGTC HYRFCCEHRH
     MRLAQASCSN YDTPRWATTP PPLAGGAGGA GGAGGGPGPG QAGWLEGGRT GGAGGRGGEG
     PGGSTAYVVC GVISFALAVG VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQAGPGTRP
     DRARSSSLTP GIGGPDSMPP RTPKNLYNTV KTPNLDWRAL PPPSPSLHYS TLSCSRSFHN
     LSHLPPSYEA AVKSELNRYS SLKRLAEKDL DEAYLKRRPL ELPRGTLPLH ALRRPGTGGG
     YRMEAWGGPE ELGLAPAPNP RRVMSQEHLL GDGGRSRYEF TLPRARLVSQ EHLLLSSPEA
     LRQSREHLLS PPRSPALPPD PTARASLAAS HSNLLLGPGG PPTPLRGLPP PSSLHAHHHH
     ALHGSPQPAW MSDAGGGGGT LARRPPFQRQ GTLEQLQFIP GHHLPQHLRT ASKNEVTV
//