ID   CGB1_HUMAN              Reviewed;         187 AA.
AC   A6NKQ9; A4FVC8; A8MUK6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 3.
DT   13-FEB-2019, entry version 103.
DE   RecName: Full=Choriogonadotropin subunit beta variant 1;
DE   Flags: Precursor;
GN   Name=CGB1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX   PubMed=18048458; DOI=10.1093/molehr/gam082;
RA   Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A.,
RA   Campbell R.K., Laan M.;
RT   "Fine-scale quantification of HCG beta gene transcription in human
RT   trophoblastic and non-malignant non-trophoblastic tissues.";
RL   Mol. Hum. Reprod. 14:23-31(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   MISCELLANEOUS.
RX   PubMed=11861891; DOI=10.1093/oxfordjournals.molbev.a004085;
RA   Maston G.A., Ruvolo M.;
RT   "Chorionic gonadotropin has a recent origin within primates and an
RT   evolutionary history of selection.";
RL   Mol. Biol. Evol. 19:320-335(2002).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=16123088; DOI=10.1093/humrep/dei261;
RA   Rull K., Laan M.;
RT   "Expression of beta-subunit of HCG genes during normal and failed
RT   pregnancy.";
RL   Hum. Reprod. 20:3360-3368(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6NKQ9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NKQ9-2; Sequence=VSP_034490, VSP_034491;
CC   -!- TISSUE SPECIFICITY: Expressed in placenta, testis and pituitary.
CC       {ECO:0000269|PubMed:16123088, ECO:0000269|PubMed:18048458}.
CC   -!- MISCELLANEOUS: Encoded by a cluster of genes that have evolved by
CC       duplication from LHB. HCG-beta is encoded by six non-allelic genes
CC       (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3,
CC       CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by
CC       three amino acids in positions 2,4 and 117 have been described:
CC       type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first
CC       arose in the common ancestor of the anthropoid primates.
CC       {ECO:0000269|PubMed:11861891}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta
CC       family. {ECO:0000305}.
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DR   EMBL; AC008687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471177; EAW52436.1; -; Genomic_DNA.
DR   EMBL; BC126460; AAI26461.1; -; mRNA.
DR   CCDS; CCDS12751.2; -. [A6NKQ9-2]
DR   RefSeq; NP_203695.2; NM_033377.1. [A6NKQ9-2]
DR   UniGene; Hs.659014; -.
DR   ProteinModelPortal; A6NKQ9; -.
DR   SMR; A6NKQ9; -.
DR   BioGrid; 125315; 1.
DR   iPTMnet; A6NKQ9; -.
DR   PhosphoSitePlus; A6NKQ9; -.
DR   BioMuta; CGB1; -.
DR   jPOST; A6NKQ9; -.
DR   MaxQB; A6NKQ9; -.
DR   PRIDE; A6NKQ9; -.
DR   ProteomicsDB; 1426; -.
DR   ProteomicsDB; 1427; -. [A6NKQ9-2]
DR   DNASU; 114335; -.
DR   Ensembl; ENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
DR   GeneID; 114335; -.
DR   KEGG; hsa:114335; -.
DR   UCSC; uc002plx.4; human. [A6NKQ9-1]
DR   CTD; 114335; -.
DR   DisGeNET; 114335; -.
DR   EuPathDB; HostDB:ENSG00000267631.4; -.
DR   GeneCards; CGB1; -.
DR   HGNC; HGNC:16721; CGB1.
DR   HPA; HPA038925; -.
DR   HPA; HPA038934; -.
DR   MIM; 608823; gene.
DR   neXtProt; NX_A6NKQ9; -.
DR   OpenTargets; ENSG00000267631; -.
DR   PharmGKB; PA26435; -.
DR   eggNOG; ENOG410J0DB; Eukaryota.
DR   eggNOG; ENOG4111ZSU; LUCA.
DR   GeneTree; ENSGT00940000163162; -.
DR   HOVERGEN; HBG006698; -.
DR   InParanoid; A6NKQ9; -.
DR   KO; K10045; -.
DR   OrthoDB; 1362225at2759; -.
DR   TreeFam; TF332940; -.
DR   GeneWiki; CGB1; -.
DR   GenomeRNAi; 114335; -.
DR   PRO; PR:A6NKQ9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000267631; Expressed in 35 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; A6NKQ9; baseline.
DR   Genevisible; A6NKQ9; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IMP:AgBase.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW   Hormone; Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     50       {ECO:0000255}.
FT   CHAIN        51    187       Choriogonadotropin subunit beta variant
FT                                1.
FT                                /FTId=PRO_0000342548.
FT   CARBOHYD     63     63       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     80     80       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     59    107       {ECO:0000250}.
FT   DISULFID     73    122       {ECO:0000250}.
FT   DISULFID     76    160       {ECO:0000250}.
FT   DISULFID     84    138       {ECO:0000250}.
FT   DISULFID     88    140       {ECO:0000250}.
FT   DISULFID    143    150       {ECO:0000250}.
FT   VAR_SEQ       1     32       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_034490.
FT   VAR_SEQ      33     35       MFQ -> MSK (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_034491.
FT   VARIANT     185    185       P -> S (in dbSNP:rs35371968).
FT                                /FTId=VAR_055838.
SQ   SEQUENCE   187 AA;  20468 MW;  1EB79D84CFA36ACA CRC64;
     MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA SKEPLRPRCR
     PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP
     GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS
     PSRLPGP
//