ID   CD8B2_HUMAN             Reviewed;         211 AA.
AC   A6NJW9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   16-JAN-2019, entry version 66.
DE   RecName: Full=Putative T-cell surface glycoprotein CD8 beta-2 chain;
DE   AltName: Full=CD8b pseudogene;
DE   Flags: Precursor;
GN   Name=CD8B2 {ECO:0000312|HGNC:HGNC:1708};
GN   Synonyms=CD8BP {ECO:0000312|HGNC:HGNC:1708};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1541829;
RA   Nakayama K., Kawachi Y., Tokito S., Minami N., Yamamoto R., Imai T.,
RA   Gachelin G., Nakauchi H.;
RT   "Recent duplication of the two human CD8 beta-chain genes.";
RL   J. Immunol. 148:1919-1927(1992).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=8436166; DOI=10.1002/eji.1830230203;
RA   DiSanto J.P., Smith D., de Bruin D., Lacy E., Flomenberg N.;
RT   "Transcriptional diversity at the duplicated human CD8 beta loci.";
RL   Eur. J. Immunol. 23:320-326(1993).
CC   -!- FUNCTION: Identifies cytotoxic/suppressor T-cells that interact
CC       with MHC class I bearing targets. CD8 is thought to play a role in
CC       the process of T-cell mediated killing (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: In general heterodimer of an alpha and a beta chain
CC       linked by two disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}.
CC   -!- CAUTION: Could be the product of a pseudogene. According to
CC       PubMed:1541829, the gene appears functional but all the mRNAs
CC       identified are derived from CD8B/CD8B1. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC108868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.534308; -.
DR   ProteinModelPortal; A6NJW9; -.
DR   SMR; A6NJW9; -.
DR   BioMuta; HGNC:1708; -.
DR   PRIDE; A6NJW9; -.
DR   ProteomicsDB; 1359; -.
DR   GeneCards; CD8B2; -.
DR   HGNC; HGNC:1708; CD8B2.
DR   neXtProt; NX_A6NJW9; -.
DR   eggNOG; ENOG410IY5X; Eukaryota.
DR   eggNOG; ENOG410ZF37; LUCA.
DR   HOVERGEN; HBG105700; -.
DR   InParanoid; A6NJW9; -.
DR   PhylomeDB; A6NJW9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   5: Uncertain;
KW   Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
KW   Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    211       Putative T-cell surface glycoprotein CD8
FT                                beta-2 chain.
FT                                /FTId=PRO_0000341228.
FT   TOPO_DOM     19    171       Extracellular. {ECO:0000255}.
FT   TRANSMEM    172    192       Helical. {ECO:0000255}.
FT   TOPO_DOM    193    211       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       19    132       Ig-like V-type.
FT   CARBOHYD    102    102       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     41    116       {ECO:0000255|PROSITE-ProRule:PRU00114}.
SQ   SEQUENCE   211 AA;  23768 MW;  A8A50ECD1A8EA22D CRC64;
     MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM CIYWLRQRQA
     PSSDSHHEFL TLWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG
     SPELTFGKGT QLSVVVDFLP TTAQPTKKST LKKRVCRLPR PETQKGPLCS PVTLGLLVAG
     VLVLLVSLGV AMHLCCRRRR ARLRFMKQLY K
//