ID LRR3C_HUMAN Reviewed; 275 AA. AC A6NJW4; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 2. DT 16-JAN-2019, entry version 93. DE RecName: Full=Leucine-rich repeat-containing protein 3C; DE Flags: Precursor; GN Name=LRRC3C; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-117. RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.; RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in RT human."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=EAW60623.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471152; EAW60623.1; ALT_SEQ; Genomic_DNA. DR EMBL; DY655553; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS54121.1; -. DR RefSeq; NP_001182474.1; NM_001195545.1. DR RefSeq; XP_011522460.1; XM_011524158.2. DR RefSeq; XP_016879492.1; XM_017024003.1. DR UniGene; Hs.145136; -. DR UniGene; Hs.602305; -. DR ProteinModelPortal; A6NJW4; -. DR SMR; A6NJW4; -. DR IntAct; A6NJW4; 1. DR STRING; 9606.ENSP00000367157; -. DR iPTMnet; A6NJW4; -. DR PhosphoSitePlus; A6NJW4; -. DR BioMuta; LRRC3C; -. DR jPOST; A6NJW4; -. DR PaxDb; A6NJW4; -. DR PRIDE; A6NJW4; -. DR ProteomicsDB; 1358; -. DR Ensembl; ENST00000377924; ENSP00000367157; ENSG00000204913. DR GeneID; 100505591; -. DR KEGG; hsa:100505591; -. DR UCSC; uc021twv.2; human. DR CTD; 100505591; -. DR EuPathDB; HostDB:ENSG00000204913.5; -. DR GeneCards; LRRC3C; -. DR HGNC; HGNC:40034; LRRC3C. DR HPA; HPA071271; -. DR neXtProt; NX_A6NJW4; -. DR OpenTargets; ENSG00000204913; -. DR eggNOG; KOG4237; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00940000154360; -. DR HOVERGEN; HBG052349; -. DR InParanoid; A6NJW4; -. DR OMA; EEELCGT; -. DR OrthoDB; 1056523at2759; -. DR PhylomeDB; A6NJW4; -. DR TreeFam; TF334047; -. DR ChiTaRS; LRRC3C; human. DR GenomeRNAi; 100505591; -. DR PRO; PR:A6NJW4; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000204913; Expressed in 26 organ(s), highest expression level in heart left ventricle. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR Pfam; PF13855; LRR_8; 1. DR SMART; SM00369; LRR_TYP; 3. DR PROSITE; PS51450; LRR; 3. PE 2: Evidence at transcript level; KW Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; KW Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 41 {ECO:0000255}. FT CHAIN 42 275 Leucine-rich repeat-containing protein FT 3C. FT /FTId=PRO_0000345962. FT TRANSMEM 225 245 Helical. {ECO:0000255}. FT DOMAIN 42 79 LRRNT. FT REPEAT 80 101 LRR 1. FT REPEAT 104 125 LRR 2. FT REPEAT 129 150 LRR 3. FT DOMAIN 160 212 LRRCT. FT CARBOHYD 156 156 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. SQ SEQUENCE 275 AA; 29314 MW; 0C09514F5D8CB9E7 CRC64; MRMTSSSFVS YCTPGLCQFM AMLPTAGHLL PLLLVIGTGG TVPSPQVPPR GCYVAKEAGE RTFRCSQAGL SAVPSGIPND TRKLYLDANQ LASVPAGAFQ HLPVLEELDL SHNALAHLSG AAFQGLEGTL RHLDLSANQL ASVPVEAFVG LQIQVNLSAN PWHCDCALQE VLRQVRLVPG TGTGIVCGSG ARPDLVGQEF LLLAGEEELC GSGWGGARRS TDVALLVTMG GWLTLMVAYL VHYVWQNRDE TRRSLKRAPV LPVRSEDSSI LSTVV //