ID   IGIP_HUMAN              Reviewed;          53 AA.
AC   A6NJ69;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   16-JAN-2019, entry version 70.
DE   RecName: Full=IgA-inducing protein homolog;
DE   Flags: Precursor;
GN   Name=IGIP; Synonyms=C5orf53;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
CC   -!- FUNCTION: Enhances IgA secretion from B-cells stimulated via CD40.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AC011379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS34244.1; -.
DR   RefSeq; NP_001007190.1; NM_001007189.1.
DR   UniGene; Hs.696360; -.
DR   ProteinModelPortal; A6NJ69; -.
DR   BioGrid; 138896; 2.
DR   IntAct; A6NJ69; 1.
DR   BioMuta; IGIP; -.
DR   PaxDb; A6NJ69; -.
DR   PRIDE; A6NJ69; -.
DR   ProteomicsDB; 1312; -.
DR   Ensembl; ENST00000333305; ENSP00000327344; ENSG00000182700.
DR   GeneID; 492311; -.
DR   KEGG; hsa:492311; -.
DR   UCSC; uc003lfb.2; human.
DR   CTD; 492311; -.
DR   EuPathDB; HostDB:ENSG00000182700.4; -.
DR   GeneCards; IGIP; -.
DR   HGNC; HGNC:33847; IGIP.
DR   HPA; HPA041877; -.
DR   HPA; HPA048615; -.
DR   neXtProt; NX_A6NJ69; -.
DR   PharmGKB; PA164717341; -.
DR   eggNOG; ENOG410J4EY; Eukaryota.
DR   eggNOG; ENOG4111AX2; LUCA.
DR   GeneTree; ENSGT00390000001137; -.
DR   HOGENOM; HOG000113011; -.
DR   HOVERGEN; HBG095175; -.
DR   InParanoid; A6NJ69; -.
DR   OMA; SVLGCNI; -.
DR   OrthoDB; 1624806at2759; -.
DR   PhylomeDB; A6NJ69; -.
DR   TreeFam; TF341188; -.
DR   ChiTaRS; IGIP; human.
DR   GenomeRNAi; 492311; -.
DR   PRO; PR:A6NJ69; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000182700; Expressed in 89 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A6NJ69; baseline and differential.
DR   Genevisible; A6NJ69; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038815; IGIP.
DR   PANTHER; PTHR39224; PTHR39224; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     30       {ECO:0000255}.
FT   CHAIN        31     53       IgA-inducing protein homolog.
FT                                /FTId=PRO_0000332153.
SQ   SEQUENCE   53 AA;  5937 MW;  3DF387501660E00C CRC64;
     MCSYYHMKKR SVSGCNITIF AVMFSHLSAG KSPCGNQANV LCISRLEFVQ YQS
//