ID   PRS29_HUMAN             Reviewed;         313 AA.
AC   A6NIE9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 3.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Putative serine protease 29;
DE            EC=3.4.21.-;
DE   AltName: Full=Implantation serine proteinase 2-like protein;
DE            Short=ISP2-like protein;
DE   Flags: Precursor;
GN   Name=PRSS29P; Synonyms=ISP2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC120498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.738703; -.
DR   ProteinModelPortal; A6NIE9; -.
DR   SMR; A6NIE9; -.
DR   BioMuta; HGNC:17542; -.
DR   jPOST; A6NIE9; -.
DR   PRIDE; A6NIE9; -.
DR   ProteomicsDB; 1266; -.
DR   TopDownProteomics; A6NIE9; -.
DR   GeneCards; PRSS29P; -.
DR   HGNC; HGNC:17542; PRSS29P.
DR   neXtProt; NX_A6NIE9; -.
DR   HOGENOM; HOG000251820; -.
DR   HOVERGEN; HBG013304; -.
DR   InParanoid; A6NIE9; -.
DR   PhylomeDB; A6NIE9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   5: Uncertain;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Signal.
FT   SIGNAL        1      ?       {ECO:0000255}.
FT   CHAIN         ?    313       Putative serine protease 29.
FT                                /FTId=PRO_0000349227.
FT   DOMAIN       68    310       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   COMPBIAS      2     29       Pro-rich.
FT   ACT_SITE    114    114       Charge relay system. {ECO:0000250}.
FT   ACT_SITE    161    161       Charge relay system. {ECO:0000250}.
FT   ACT_SITE    262    262       Charge relay system. {ECO:0000250}.
FT   CARBOHYD    143    143       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     99    115       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    193    268       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    226    249       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    258    286       {ECO:0000255|PROSITE-ProRule:PRU00274}.
SQ   SEQUENCE   313 AA;  34063 MW;  4DE6123C63C5F67C CRC64;
     MPTTPDPGSE PPARTPRPPP LTPGLSPQPA LHALSPQLLL LLFLAVSSLG SCSTGSPVPV
     PENDLVGIVG GHNAPPGKWP WQVSLRVYSY HWASWAHICG GSLIHPQWVL TAAHCIFWKD
     TDPSIYRIHA GDVYLYGGRG LLNVSRIIVH PNYVTAGLGA DVALLQLEPH DLSNVRTVKL
     SPVSLELTPK DQCWVTGWGA IIRKESLPPP YRLQQASVQV LENAVCEQPY RNASGHTGDR
     QLILDDMLCA GSEGRDSCYG DSGGPLVCRL RGSWRLVGVV SWGYGCTLRD FPGVYTHVQI
     YVPWILQQVG ELP
//