ID LIRA5_HUMAN Reviewed; 299 AA. AC A6NI73; A6NHI3; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 24-JUL-2007, sequence version 1. DT 13-FEB-2019, entry version 98. DE RecName: Full=Leukocyte immunoglobulin-like receptor subfamily A member 5; DE AltName: Full=CD85 antigen-like family member F; DE AltName: Full=Immunoglobulin-like transcript 11; DE Short=ILT-11; DE AltName: Full=Leukocyte immunoglobulin-like receptor 9; DE Short=LIR-9; DE AltName: CD_antigen=CD85f; DE Flags: Precursor; GN Name=LILRA5; Synonyms=ILT11, LILRB7, LIR9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=10941842; DOI=10.1007/s002510000187; RA Wende H., Volz A., Ziegler A.; RT "Extensive gene duplications and a large inversion characterize the RT human leukocyte receptor cluster."; RL Immunogenetics 51:703-713(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE RP SPECIFICITY, AND SUBCELLULAR LOCATION. RX PubMed=12393390; DOI=10.1182/blood-2002-05-1432; RA Borges L., Kubin M., Kuhlman T.; RT "LIR9, an immunoglobulin-superfamily-activating receptor, is expressed RT as a transmembrane and as a secreted molecule."; RL Blood 101:1484-1486(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 42-237, FUNCTION, AND RP DISULFIDE BOND. RX PubMed=16675463; DOI=10.1074/jbc.M603076200; RA Shiroishi M., Kajikawa M., Kuroki K., Ose T., Kohda D., Maenaka K.; RT "Crystal structure of the human monocyte-activating receptor, 'Group RT 2' leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11)."; RL J. Biol. Chem. 281:19536-19544(2006). CC -!- FUNCTION: May play a role in triggering innate immune responses. CC Does not seem to play a role for any class I MHC antigen CC recognition. {ECO:0000269|PubMed:16675463}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12393390}; CC Single-pass type I membrane protein {ECO:0000255}. CC -!- SUBCELLULAR LOCATION: Isoform 3: Secreted CC {ECO:0000269|PubMed:12393390}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; Synonyms=LIR9m1; CC IsoId=A6NI73-1; Sequence=Displayed; CC Name=2; Synonyms=LIR9m2; CC IsoId=A6NI73-2; Sequence=VSP_031276; CC Name=3; Synonyms=LIR9s1; CC IsoId=A6NI73-3; Sequence=VSP_031277; CC Name=4; Synonyms=LIR9s2; CC IsoId=A6NI73-4; Sequence=VSP_031276, VSP_031277; CC -!- TISSUE SPECIFICITY: Expressed mostly in tissues of the CC hematopoietic system, including bone marrow, spleen, lymph node CC and peripheral leukocytes. Among leukocytes, monocytes and CC neutrophils express the highest level. Expressed in CD14+ CC monocytes, but not in T-cells, B-cells or natural killer (NK) CC cells (at protein level). {ECO:0000269|PubMed:12393390}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF212842; AAF73849.1; -; mRNA. DR EMBL; AF324830; AAK52451.1; -; mRNA. DR EMBL; AF499916; AAN27925.1; -; mRNA. DR EMBL; AF499917; AAN27926.1; -; mRNA. DR EMBL; AF499918; AAN27927.1; -; mRNA. DR EMBL; AF499919; AAN27928.1; -; mRNA. DR EMBL; AC008984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471135; EAW72226.1; -; Genomic_DNA. DR EMBL; CH471135; EAW72227.1; -; Genomic_DNA. DR CCDS; CCDS12888.1; -. [A6NI73-1] DR CCDS; CCDS12889.1; -. [A6NI73-2] DR RefSeq; NP_067073.1; NM_021250.3. [A6NI73-1] DR RefSeq; NP_870994.1; NM_181879.2. [A6NI73-3] DR RefSeq; NP_871714.1; NM_181985.3. [A6NI73-2] DR RefSeq; NP_871715.1; NM_181986.2. [A6NI73-4] DR UniGene; Hs.710986; -. DR PDB; 2D3V; X-ray; 1.85 A; A=42-237. DR PDBsum; 2D3V; -. DR ProteinModelPortal; A6NI73; -. DR SMR; A6NI73; -. DR STRING; 9606.ENSP00000301219; -. DR iPTMnet; A6NI73; -. DR PhosphoSitePlus; A6NI73; -. DR BioMuta; LILRA5; -. DR PaxDb; A6NI73; -. DR PRIDE; A6NI73; -. DR ProteomicsDB; 1250; -. DR ProteomicsDB; 1251; -. [A6NI73-2] DR ProteomicsDB; 1252; -. [A6NI73-3] DR ProteomicsDB; 1253; -. [A6NI73-4] DR DNASU; 353514; -. DR Ensembl; ENST00000432233; ENSP00000404236; ENSG00000187116. [A6NI73-1] DR Ensembl; ENST00000486742; ENSP00000484372; ENSG00000187116. [A6NI73-2] DR Ensembl; ENST00000611164; ENSP00000482658; ENSG00000278355. [A6NI73-2] DR Ensembl; ENST00000612266; ENSP00000480436; ENSG00000274914. [A6NI73-4] DR Ensembl; ENST00000612621; ENSP00000484785; ENSG00000278355. [A6NI73-1] DR Ensembl; ENST00000613559; ENSP00000484775; ENSG00000274914. [A6NI73-3] DR Ensembl; ENST00000614299; ENSP00000483992; ENSG00000274914. [A6NI73-2] DR Ensembl; ENST00000615820; ENSP00000480204; ENSG00000274113. [A6NI73-2] DR Ensembl; ENST00000616133; ENSP00000484062; ENSG00000275404. [A6NI73-4] DR Ensembl; ENST00000618711; ENSP00000478354; ENSG00000274914. [A6NI73-1] DR Ensembl; ENST00000619516; ENSP00000480382; ENSG00000278355. [A6NI73-4] DR Ensembl; ENST00000620091; ENSP00000480458; ENSG00000274113. [A6NI73-1] DR Ensembl; ENST00000620692; ENSP00000483958; ENSG00000275404. [A6NI73-3] DR Ensembl; ENST00000620898; ENSP00000484869; ENSG00000275404. [A6NI73-2] DR Ensembl; ENST00000621042; ENSP00000482882; ENSG00000275404. [A6NI73-1] DR Ensembl; ENST00000621482; ENSP00000477785; ENSG00000278355. [A6NI73-3] DR GeneID; 353514; -. DR KEGG; hsa:353514; -. DR UCSC; uc032idp.1; human. [A6NI73-1] DR CTD; 353514; -. DR DisGeNET; 353514; -. DR EuPathDB; HostDB:ENSG00000187116.13; -. DR GeneCards; LILRA5; -. DR HGNC; HGNC:16309; LILRA5. DR MIM; 606047; gene. DR neXtProt; NX_A6NI73; -. DR OpenTargets; ENSG00000187116; -. DR PharmGKB; PA142671547; -. DR eggNOG; ENOG410JB9F; Eukaryota. DR eggNOG; ENOG41114EZ; LUCA. DR GeneTree; ENSGT00940000153160; -. DR HOGENOM; HOG000234395; -. DR HOVERGEN; HBG074353; -. DR InParanoid; A6NI73; -. DR KO; K06512; -. DR OMA; SSHRGTF; -. DR OrthoDB; 1327293at2759; -. DR PhylomeDB; A6NI73; -. DR TreeFam; TF336644; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR EvolutionaryTrace; A6NI73; -. DR GenomeRNAi; 353514; -. DR PRO; PR:A6NI73; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000187116; Expressed in 124 organ(s), highest expression level in blood. DR Genevisible; A6NI73; HS. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005615; C:extracellular space; IMP:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IDA:UniProtKB. DR GO; GO:2000666; P:negative regulation of interleukin-13 secretion; IDA:UniProtKB. DR GO; GO:0051928; P:positive regulation of calcium ion transport; IDA:UniProtKB. DR GO; GO:0050867; P:positive regulation of cell activation; IDA:UniProtKB. DR GO; GO:0050729; P:positive regulation of inflammatory response; IDA:UniProtKB. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:UniProtKB. DR GO; GO:2001181; P:positive regulation of interleukin-10 secretion; IDA:UniProtKB. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB. DR GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; IMP:UniProtKB. DR GO; GO:1904469; P:positive regulation of tumor necrosis factor secretion; IDA:UniProtKB. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR Pfam; PF13895; Ig_2; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 2. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; KW Innate immunity; Membrane; Receptor; Reference proteome; Repeat; KW Secreted; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 41 {ECO:0000255}. FT CHAIN 42 299 Leukocyte immunoglobulin-like receptor FT subfamily A member 5. FT /FTId=PRO_0000318708. FT TOPO_DOM 42 268 Extracellular. {ECO:0000255}. FT TRANSMEM 269 289 Helical. {ECO:0000255}. FT TOPO_DOM 290 299 Cytoplasmic. {ECO:0000255}. FT DOMAIN 51 136 Ig-like C2-type 1. FT DOMAIN 142 230 Ig-like C2-type 2. FT CARBOHYD 43 43 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 157 157 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 248 248 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 67 116 {ECO:0000244|PDB:2D3V, FT ECO:0000269|PubMed:16675463}. FT DISULFID 162 214 {ECO:0000244|PDB:2D3V, FT ECO:0000269|PubMed:16675463}. FT VAR_SEQ 31 42 Missing (in isoform 2 and isoform 4). FT {ECO:0000303|PubMed:12393390}. FT /FTId=VSP_031276. FT VAR_SEQ 239 299 AADNLSPSQNKSDSGTASHLQDYAVENLIRMGMAGLILVVL FT GILIFQDWHSQRSPQAAAGR -> EEATVFSSTIQGSQTGC FT GELYRQGSPC (in isoform 3 and isoform 4). FT {ECO:0000303|PubMed:12393390}. FT /FTId=VSP_031277. FT CONFLICT 100 100 R -> G (in Ref. 1; AAF73849). FT {ECO:0000305}. FT CONFLICT 220 220 H -> R (in Ref. 1; AAF73849). FT {ECO:0000305}. FT STRAND 48 53 {ECO:0000244|PDB:2D3V}. FT STRAND 55 58 {ECO:0000244|PDB:2D3V}. FT STRAND 63 68 {ECO:0000244|PDB:2D3V}. FT STRAND 75 80 {ECO:0000244|PDB:2D3V}. FT STRAND 87 90 {ECO:0000244|PDB:2D3V}. FT STRAND 98 105 {ECO:0000244|PDB:2D3V}. FT HELIX 108 110 {ECO:0000244|PDB:2D3V}. FT STRAND 112 120 {ECO:0000244|PDB:2D3V}. FT STRAND 131 136 {ECO:0000244|PDB:2D3V}. FT STRAND 143 145 {ECO:0000244|PDB:2D3V}. FT STRAND 159 166 {ECO:0000244|PDB:2D3V}. FT STRAND 169 175 {ECO:0000244|PDB:2D3V}. FT STRAND 182 186 {ECO:0000244|PDB:2D3V}. FT STRAND 195 200 {ECO:0000244|PDB:2D3V}. FT STRAND 210 218 {ECO:0000244|PDB:2D3V}. FT STRAND 221 225 {ECO:0000244|PDB:2D3V}. FT STRAND 232 234 {ECO:0000244|PDB:2D3V}. SQ SEQUENCE 299 AA; 32755 MW; F5EE25361D4E0F02 CRC64; MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW AEPGSVISRG NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR FSIPSMTEHH AGRYRCYYYS PAGWSEPSDP LELVVTGFYN KPTLSALPSP VVTSGENVTL QCGSRLRFDR FILTEEGDHK LSWTLDSQLT PSGQFQALFP VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA DNLSPSQNKS DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR //