ID   MANS4_HUMAN             Reviewed;         340 AA.
AC   A6NHS7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 3.
DT   16-JAN-2019, entry version 68.
DE   RecName: Full=MANSC domain-containing protein 4;
DE   Flags: Precursor;
GN   Name=MANSC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC009509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53770.1; -.
DR   RefSeq; NP_001139693.1; NM_001146221.1.
DR   ProteinModelPortal; A6NHS7; -.
DR   iPTMnet; A6NHS7; -.
DR   PhosphoSitePlus; A6NHS7; -.
DR   BioMuta; MANSC4; -.
DR   jPOST; A6NHS7; -.
DR   PaxDb; A6NHS7; -.
DR   PRIDE; A6NHS7; -.
DR   ProteomicsDB; 1224; -.
DR   Ensembl; ENST00000381273; ENSP00000370673; ENSG00000205693.
DR   GeneID; 100287284; -.
DR   KEGG; hsa:100287284; -.
DR   UCSC; uc010sjs.2; human.
DR   CTD; 100287284; -.
DR   EuPathDB; HostDB:ENSG00000205693.3; -.
DR   GeneCards; MANSC4; -.
DR   HGNC; HGNC:40023; MANSC4.
DR   HPA; HPA039454; -.
DR   HPA; HPA039682; -.
DR   neXtProt; NX_A6NHS7; -.
DR   eggNOG; ENOG410IGYP; Eukaryota.
DR   eggNOG; ENOG4112575; LUCA.
DR   GeneTree; ENSGT00940000153377; -.
DR   HOVERGEN; HBG108731; -.
DR   InParanoid; A6NHS7; -.
DR   OMA; TISPFFV; -.
DR   OrthoDB; 1127205at2759; -.
DR   PhylomeDB; A6NHS7; -.
DR   TreeFam; TF353070; -.
DR   PRO; PR:A6NHS7; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000205693; Expressed in 61 organ(s), highest expression level in cerebellar hemisphere.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR013980; MANSC_dom.
DR   InterPro; IPR011106; MANSC_N.
DR   Pfam; PF07502; MANEC; 1.
DR   SMART; SM00765; MANEC; 1.
DR   PROSITE; PS50986; MANSC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25    340       MANSC domain-containing protein 4.
FT                                /FTId=PRO_0000349176.
FT   TOPO_DOM     25    284       Extracellular. {ECO:0000255}.
FT   TRANSMEM    285    305       Helical. {ECO:0000255}.
FT   TOPO_DOM    306    340       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       37    117       MANSC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00341}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    187    187       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    260    260       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   340 AA;  37879 MW;  4C5393FDA04AFB87 CRC64;
     MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK LGAQFLKYYS
     ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC PTLESCILEP GTSAILYNIT
     DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ
     DLVVNTNSTS YSKELTTDFW ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID
     TKLSHMPVPP GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC
     CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS
//