ID   F187A_HUMAN             Reviewed;         413 AA.
AC   A6NFU0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   16-JAN-2019, entry version 85.
DE   RecName: Full=Ig-like V-type domain-containing protein FAM187A;
DE   Flags: Precursor;
GN   Name=FAM187A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR   EMBL; AC015936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86601.1; -.
DR   ProteinModelPortal; A6NFU0; -.
DR   SMR; A6NFU0; -.
DR   STRING; 9606.ENSP00000329499; -.
DR   BioMuta; FAM187A; -.
DR   jPOST; A6NFU0; -.
DR   PaxDb; A6NFU0; -.
DR   PRIDE; A6NFU0; -.
DR   ProteomicsDB; 1077; -.
DR   Ensembl; ENST00000331733; ENSP00000329499; ENSG00000214447.
DR   UCSC; uc002ihp.2; human.
DR   EuPathDB; HostDB:ENSG00000214447.4; -.
DR   GeneCards; FAM187A; -.
DR   HGNC; HGNC:35153; FAM187A.
DR   HPA; HPA022794; -.
DR   neXtProt; NX_A6NFU0; -.
DR   eggNOG; ENOG410IE2U; Eukaryota.
DR   eggNOG; ENOG410XNRD; LUCA.
DR   GeneTree; ENSGT00390000004038; -.
DR   HOGENOM; HOG000155662; -.
DR   HOVERGEN; HBG108742; -.
DR   InParanoid; A6NFU0; -.
DR   OMA; SMRVFID; -.
DR   PhylomeDB; A6NFU0; -.
DR   TreeFam; TF332178; -.
DR   PRO; PR:A6NFU0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000214447; Expressed in 82 organ(s), highest expression level in left testis.
DR   Genevisible; A6NFU0; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR039311; FAM187A/B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR32178; PTHR32178; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18    413       Ig-like V-type domain-containing protein
FT                                FAM187A.
FT                                /FTId=PRO_0000340654.
FT   TOPO_DOM     18    376       Extracellular. {ECO:0000255}.
FT   TRANSMEM    377    397       Helical. {ECO:0000255}.
FT   TOPO_DOM    398    413       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      267    361       Ig-like V-type.
FT   COMPBIAS    398    408       Cys-rich.
FT   CARBOHYD    317    317       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    289    345       {ECO:0000255|PROSITE-ProRule:PRU00114}.
SQ   SEQUENCE   413 AA;  47349 MW;  580178965D3F9631 CRC64;
     MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE LPCHCKPEEV
     PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML TRFSIRMFSL LVFRAQSEDS
     GLYFCGTRKG DYFYAYDVDI QNSEGMVATF QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR
     CGVRGEQWRI GLCYLQSPDL SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL
     VPCEKTKTIR EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
     DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV LVAGFRLGVT
     SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC CCYLFHCCPS FSP
//