ID   TM235_HUMAN             Reviewed;         223 AA.
AC   A6NFC5; C9JRE6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 3.
DT   16-JAN-2019, entry version 74.
DE   RecName: Full=Transmembrane protein 235;
DE   Flags: Precursor;
GN   Name=TMEM235;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 3-223 (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=21689651; DOI=10.1016/j.febslet.2011.05.060;
RA   Maher G.J., Hilton E.N., Urquhart J.E., Davidson A.E., Spencer H.L.,
RA   Black G.C., Manson F.D.;
RT   "The cataract-associated protein TMEM114, and TMEM235, are
RT   glycosylated transmembrane proteins that are distinct from claudin
RT   family members.";
RL   FEBS Lett. 585:2187-2192(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=A6NFC5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NFC5-2; Sequence=VSP_040887;
CC       Name=3;
CC         IsoId=A6NFC5-3; Sequence=VSP_040888;
CC   -!- DEVELOPMENTAL STAGE: Not detected before gestational days 53-54.
CC       Expressed in the eye at gestational week 10.
CC       {ECO:0000269|PubMed:21689651}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC087645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471099; EAW89517.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC042066; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BM907084; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS56046.1; -. [A6NFC5-1]
DR   CCDS; CCDS56047.1; -. [A6NFC5-2]
DR   CCDS; CCDS56048.1; -. [A6NFC5-3]
DR   RefSeq; NP_001191139.1; NM_001204210.1. [A6NFC5-1]
DR   RefSeq; NP_001191140.1; NM_001204211.1. [A6NFC5-2]
DR   RefSeq; NP_001191141.1; NM_001204212.1. [A6NFC5-3]
DR   UniGene; Hs.632228; -.
DR   ProteinModelPortal; A6NFC5; -.
DR   BioMuta; TMEM235; -.
DR   PaxDb; A6NFC5; -.
DR   PRIDE; A6NFC5; -.
DR   ProteomicsDB; 1038; -.
DR   ProteomicsDB; 1039; -. [A6NFC5-2]
DR   ProteomicsDB; 1040; -. [A6NFC5-3]
DR   Ensembl; ENST00000374946; ENSP00000364084; ENSG00000204278. [A6NFC5-2]
DR   Ensembl; ENST00000421688; ENSP00000402790; ENSG00000204278. [A6NFC5-1]
DR   Ensembl; ENST00000550981; ENSP00000447766; ENSG00000204278. [A6NFC5-2]
DR   Ensembl; ENST00000551068; ENSP00000446514; ENSG00000204278. [A6NFC5-1]
DR   Ensembl; ENST00000586400; ENSP00000466793; ENSG00000204278. [A6NFC5-3]
DR   GeneID; 283999; -.
DR   KEGG; hsa:283999; -.
DR   UCSC; uc002jvk.4; human. [A6NFC5-1]
DR   CTD; 283999; -.
DR   EuPathDB; HostDB:ENSG00000204278.12; -.
DR   GeneCards; TMEM235; -.
DR   HGNC; HGNC:27563; TMEM235.
DR   HPA; HPA053939; -.
DR   neXtProt; NX_A6NFC5; -.
DR   OpenTargets; ENSG00000204278; -.
DR   eggNOG; ENOG410J07W; Eukaryota.
DR   eggNOG; ENOG410YPVG; LUCA.
DR   GeneTree; ENSGT00390000011615; -.
DR   HOVERGEN; HBG076521; -.
DR   InParanoid; A6NFC5; -.
DR   OrthoDB; 1265742at2759; -.
DR   PhylomeDB; A6NFC5; -.
DR   GenomeRNAi; 283999; -.
DR   PRO; PR:A6NFC5; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000204278; Expressed in 61 organ(s), highest expression level in substantia nigra.
DR   ExpressionAtlas; A6NFC5; baseline and differential.
DR   Genevisible; A6NFC5; HS.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039951; TMEM114/TMEM235.
DR   PANTHER; PTHR20516; PTHR20516; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     28       {ECO:0000255}.
FT   CHAIN        29    223       Transmembrane protein 235.
FT                                /FTId=PRO_0000406902.
FT   TRANSMEM     96    116       Helical. {ECO:0000255}.
FT   TRANSMEM    126    146       Helical. {ECO:0000255}.
FT   TRANSMEM    176    196       Helical. {ECO:0000255}.
FT   CARBOHYD     41     41       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ      64     91       GQNGCIPLVDPFASESLDVSTSVQHLIL -> V (in
FT                                isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_040887.
FT   VAR_SEQ      65    137       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_040888.
SQ   SEQUENCE   223 AA;  23360 MW;  566E4D43388B9DDF CRC64;
     MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR
     ICEGQNGCIP LVDPFASESL DVSTSVQHLI LLHRAVIVVL PLSLVLLVCG WICGLLSSLA
     QSVSLLLFTG CYFLLGSVLT LAGVSIYISY SHLAFAETVQ QYGPQHMQGV RVSFGWSMAL
     AWGSCALEAF SGTLLLSAAW TLSLSPPICG HLSPQQVGGR GGD
//