ID   ANTRL_HUMAN             Reviewed;         631 AA.
AC   A6NF34; H3BPS2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 3.
DT   13-FEB-2019, entry version 85.
DE   RecName: Full=Anthrax toxin receptor-like;
DE   Flags: Precursor;
GN   Name=ANTXRL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ATR family. {ECO:0000305}.
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DR   EMBL; AL450388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL603965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS60524.1; -.
DR   RefSeq; NP_001265617.1; NM_001278688.2.
DR   UniGene; Hs.538515; -.
DR   ProteinModelPortal; A6NF34; -.
DR   SMR; A6NF34; -.
DR   STRING; 9606.ENSP00000455449; -.
DR   iPTMnet; A6NF34; -.
DR   PhosphoSitePlus; A6NF34; -.
DR   BioMuta; ANTXRL; -.
DR   PaxDb; A6NF34; -.
DR   PRIDE; A6NF34; -.
DR   ProteomicsDB; 1025; -.
DR   Ensembl; ENST00000620264; ENSP00000480615; ENSG00000274209.
DR   GeneID; 195977; -.
DR   KEGG; hsa:195977; -.
DR   UCSC; uc031wet.2; human.
DR   CTD; 195977; -.
DR   EuPathDB; HostDB:ENSG00000274209.4; -.
DR   GeneCards; ANTXRL; -.
DR   HGNC; HGNC:27277; ANTXRL.
DR   neXtProt; NX_A6NF34; -.
DR   OpenTargets; ENSG00000274209; -.
DR   eggNOG; ENOG410J9D0; Eukaryota.
DR   eggNOG; ENOG410XUV2; LUCA.
DR   GeneTree; ENSGT00940000157727; -.
DR   HOVERGEN; HBG096808; -.
DR   InParanoid; A6NF34; -.
DR   OMA; VAHAFQD; -.
DR   OrthoDB; 613698at2759; -.
DR   TreeFam; TF328943; -.
DR   ChiTaRS; ANTXRL; human.
DR   GenomeRNAi; 195977; -.
DR   PRO; PR:A6NF34; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000274209; Expressed in 66 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; A6NF34; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:1901998; P:toxin transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR017360; Anthrax_toxin_rcpt.
DR   InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR16059; PTHR16059; 1.
DR   Pfam; PF05587; Anth_Ig; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Membrane; Metal-binding; Polymorphism;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    631       Anthrax toxin receptor-like.
FT                                /FTId=PRO_0000332166.
FT   TOPO_DOM     28    353       Extracellular. {ECO:0000255}.
FT   TRANSMEM    354    374       Helical. {ECO:0000255}.
FT   TOPO_DOM    375    631       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       76    246       VWFA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00219}.
FT   COMPBIAS     51     54       Poly-His.
FT   COMPBIAS    383    424       Pro-rich.
FT   METAL        84     84       Divalent metal cation. {ECO:0000250}.
FT   METAL        86     86       Divalent metal cation. {ECO:0000250}.
FT   METAL       150    150       Divalent metal cation. {ECO:0000250}.
FT   VARIANT     550    550       P -> R (in dbSNP:rs7091749).
FT                                /FTId=VAR_042963.
SQ   SEQUENCE   631 AA;  70629 MW;  5C9D12C7E701D784 CRC64;
     MGSHESLGPY FLVFLLLLLL PPPLFRAGSL RYHGPDWRIF HRLALGSRRA HHHHGPGWRQ
     HWRQGQAGHR CQGSFDLYFI LDKSGSVNNN WIDLYMWVEE TVARFQSPNI RMCFITYSTD
     GQTVLPLTSD KNRIKNGLDQ LQKIVPDGHT FMQAGFRKAI QQIESFNSGN KVPSMIIAMT
     DGELVAHAFQ DTLREAQKAR KLGANVYTLG VADYNLDQIT AIADSPGHVF AVENGFKALR
     STIDALTSKV CLDVTSVEPS SECVGEPYHV VIHGNGFQNL KKRDEVICRF IFNESTIIDE
     KPTSIDNNSM NCPGPKLEKP GEEYSIEVSL NKGKTFFKSN VSITSTTCGI FRNWLYFVPL
     LLLVPLLLCC VWRLCRKQTV KEPPPVQKPE KEPEQEKPPS PPPPPPPPPP PLPPPPPAPV
     NTCPTVIICC CGCQGVGGMR RIEGNLDTFC DLSHASCHQV PWMCCQSRDQ GRYLSLALAQ
     SQYAQAPCCP RICFPHSQEC LSLPQAPCSP RMCLRHSREC LALKQARCSP NICLRHSQHS
     RECLARKQAP CSPRICLRHS PEYFSQAQTL CNPKSCLQPS RECLPLTCSS RCRLPPARCL
     RPPSRMLPLL SPLLRHTAEP PLSLPPSEPN F
//