ID   A6NEP9_HUMAN            Unreviewed;       223 AA.
AC   A6NEP9;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 2.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
DE   Flags: Fragment;
GN   Name=TSPAN14 {ECO:0000313|Ensembl:ENSP00000361230};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000361230, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000361230, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000361230}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS00595319}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361218}.
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DR   EMBL; AC021028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A6NEP9; -.
DR   jPOST; A6NEP9; -.
DR   MaxQB; A6NEP9; -.
DR   PeptideAtlas; A6NEP9; -.
DR   PRIDE; A6NEP9; -.
DR   Ensembl; ENST00000372157; ENSP00000361230; ENSG00000108219.
DR   UCSC; uc057uno.1; human.
DR   EuPathDB; HostDB:ENSG00000108219.14; -.
DR   HGNC; HGNC:23303; TSPAN14.
DR   OpenTargets; ENSG00000108219; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000159235; -.
DR   HOGENOM; HOG000230652; -.
DR   HOVERGEN; HBG108605; -.
DR   ChiTaRS; TSPAN14; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000108219; Expressed in 213 organ(s), highest expression level in right lung.
DR   ExpressionAtlas; A6NEP9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005};
KW   Proteomics identification {ECO:0000213|EPD:A6NEP9,
KW   ECO:0000213|MaxQB:A6NEP9, ECO:0000213|PeptideAtlas:A6NEP9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    223       Tetraspanin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002700665.
FT   TRANSMEM     34     54       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     61     85       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    203    222       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   NON_TER     223    223       {ECO:0000313|Ensembl:ENSP00000361230}.
SQ   SEQUENCE   223 AA;  25197 MW;  DFC991FADED5AE89 CRC64;
     MERKVLPCFL CLFQGVLSDL TKVTRMHGID PVVLVLMVGV VMFTLGFAGC VGALRENICL
     LNFFCGTIVL IFFLELAVAV LAFLFQDWVR DRFREFFESN IKSYRDDIDL QNLIDSLQKA
     NQCCGAYGPE DWDLNVYFNC SGASYSREKC GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS
     KWDESIFTKG CIQALESWLP RNIYIVAGVF IAISLLQIFG IFL
//