ID   LRIT2_HUMAN             Reviewed;         550 AA.
AC   A6NDA9; B7ZME6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   13-FEB-2019, entry version 108.
DE   RecName: Full=Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2;
DE   AltName: Full=Leucine-rich repeat-containing protein 22;
DE   Flags: Precursor;
GN   Name=LRIT2; Synonyms=LRRC22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Retina;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6NDA9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NDA9-2; Sequence=VSP_054539;
CC         Note=No experimental confirmation available.;
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DR   EMBL; BX648524; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC022389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC140765; AAI40766.1; -; mRNA.
DR   EMBL; BC144475; AAI44476.1; -; mRNA.
DR   CCDS; CCDS31234.1; -. [A6NDA9-1]
DR   CCDS; CCDS60581.1; -. [A6NDA9-2]
DR   RefSeq; NP_001017924.1; NM_001017924.3. [A6NDA9-1]
DR   RefSeq; NP_001271152.1; NM_001284223.1. [A6NDA9-2]
DR   UniGene; Hs.450425; -.
DR   ProteinModelPortal; A6NDA9; -.
DR   STRING; 9606.ENSP00000361185; -.
DR   iPTMnet; A6NDA9; -.
DR   PhosphoSitePlus; A6NDA9; -.
DR   BioMuta; LRIT2; -.
DR   jPOST; A6NDA9; -.
DR   MaxQB; A6NDA9; -.
DR   PaxDb; A6NDA9; -.
DR   PRIDE; A6NDA9; -.
DR   ProteomicsDB; 897; -.
DR   Ensembl; ENST00000372113; ENSP00000361185; ENSG00000204033. [A6NDA9-1]
DR   Ensembl; ENST00000538192; ENSP00000438264; ENSG00000204033. [A6NDA9-2]
DR   GeneID; 340745; -.
DR   KEGG; hsa:340745; -.
DR   UCSC; uc001kcy.5; human. [A6NDA9-1]
DR   CTD; 340745; -.
DR   DisGeNET; 340745; -.
DR   EuPathDB; HostDB:ENSG00000204033.9; -.
DR   GeneCards; LRIT2; -.
DR   HGNC; HGNC:23443; LRIT2.
DR   HPA; HPA037788; -.
DR   neXtProt; NX_A6NDA9; -.
DR   OpenTargets; ENSG00000204033; -.
DR   PharmGKB; PA162394344; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000159143; -.
DR   HOGENOM; HOG000082676; -.
DR   HOVERGEN; HBG060406; -.
DR   InParanoid; A6NDA9; -.
DR   OMA; QCVVFVT; -.
DR   OrthoDB; 770995at2759; -.
DR   PhylomeDB; A6NDA9; -.
DR   TreeFam; TF330861; -.
DR   GenomeRNAi; 340745; -.
DR   PRO; PR:A6NDA9; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000204033; Expressed in 30 organ(s), highest expression level in mucosa of transverse colon.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    550       Leucine-rich repeat, immunoglobulin-like
FT                                domain and transmembrane domain-
FT                                containing protein 2.
FT                                /FTId=PRO_0000309344.
FT   TRANSMEM    466    486       Helical. {ECO:0000255}.
FT   DOMAIN       23     54       LRRNT.
FT   REPEAT       80    103       LRR 1.
FT   REPEAT      104    125       LRR 2.
FT   REPEAT      128    149       LRR 3.
FT   REPEAT      152    173       LRR 4.
FT   DOMAIN      200    252       LRRCT.
FT   DOMAIN      253    341       Ig-like.
FT   DOMAIN      361    451       Fibronectin type-III.
FT   CARBOHYD     52     52       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    274    327       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   VAR_SEQ     297    297       D -> DGLLGGKHLTP (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_054539.
FT   VARIANT      28     28       C -> Y (in dbSNP:rs12773843).
FT                                /FTId=VAR_036935.
FT   VARIANT     179    179       K -> N (in dbSNP:rs11200927).
FT                                /FTId=VAR_036936.
FT   VARIANT     220    220       L -> F (in dbSNP:rs11200925).
FT                                /FTId=VAR_036937.
FT   VARIANT     496    496       V -> A (in dbSNP:rs12217769).
FT                                /FTId=VAR_036938.
FT   VARIANT     510    510       T -> P (in dbSNP:rs6585847).
FT                                /FTId=VAR_036939.
SQ   SEQUENCE   550 AA;  60168 MW;  F9891BB309EDD630 CRC64;
     MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP GNLSEEFKQV
     RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE HLPELRELRL EGNKLCSVPW
     TAFRATPLLR VLDLKRNKID ALPELALQFL VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC
     RQPDCGAEIL SSLVVALHDN PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ
     LFHETELSAC MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT
     SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL HAPDSLSIPS
     EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS DEAFRKEVVH IGPGINTYAV
     DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG
     AYAWAAQGPC SCSKWVLRGC LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD
     KEKGGTEDNS
//