ID   LRCL1_HUMAN             Reviewed;         159 AA.
AC   A6NCL2; H9BFB1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   16-JAN-2019, entry version 63.
DE   RecName: Full=Leucine-rich colipase-like protein 1;
DE   Flags: Precursor;
GN   Name=LRCOL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lu Y., Xue Y., Wang P., Ma D.;
RT   "Cloning and identification of a novel human gene LOC100507055.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
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DR   EMBL; JQ012741; AFD01644.1; -; mRNA.
DR   EMBL; AC131212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS73547.1; -.
DR   RefSeq; NP_001182449.1; NM_001195520.1.
DR   UniGene; Hs.282811; -.
DR   ProteinModelPortal; A6NCL2; -.
DR   BioMuta; LRCOL1; -.
DR   PRIDE; A6NCL2; -.
DR   ProteomicsDB; 843; -.
DR   Ensembl; ENST00000376608; ENSP00000479730; ENSG00000204583.
DR   GeneID; 100507055; -.
DR   KEGG; hsa:100507055; -.
DR   UCSC; uc021rgr.2; human.
DR   CTD; 100507055; -.
DR   EuPathDB; HostDB:ENSG00000204583.9; -.
DR   GeneCards; LRCOL1; -.
DR   HGNC; HGNC:44160; LRCOL1.
DR   neXtProt; NX_A6NCL2; -.
DR   OpenTargets; ENSG00000204583; -.
DR   GeneTree; ENSGT00390000012041; -.
DR   HOGENOM; HOG000202504; -.
DR   HOVERGEN; HBG108733; -.
DR   InParanoid; A6NCL2; -.
DR   OMA; QTIFLQC; -.
DR   OrthoDB; 1431911at2759; -.
DR   GenomeRNAi; 100507055; -.
DR   PRO; PR:A6NCL2; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000204583; Expressed in 80 organ(s), highest expression level in liver.
DR   ExpressionAtlas; A6NCL2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   InterPro; IPR001981; Colipase.
DR   PANTHER; PTHR10041; PTHR10041; 1.
DR   Pfam; PF15083; Colipase-like; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Reference proteome; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    159       Leucine-rich colipase-like protein 1.
FT                                /FTId=PRO_0000346758.
FT   CARBOHYD     31     31       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT      7      7       T -> M (in Ref. 1; AFD01644).
FT                                {ECO:0000305}.
FT   CONFLICT     42     42       R -> G (in Ref. 1; AFD01644).
FT                                {ECO:0000305}.
SQ   SEQUENCE   159 AA;  17834 MW;  E562F237A53DF599 CRC64;
     MAGPGWTLLL LLLLLLLLGS MAGYGPQKKL NLSHKGIGEP CRRHEECQSN CCTINSLAPH
     TLCTPKTIFL QCLPWRKPNG YRCSHDSECQ SSCCVRNNSP QELCTPQSVF LQCVPWRKPN
     GDFCSSHQEC HSQCCIQLRE YSPFRCIPRT GILAQCLPL
//