ID   VWA3A_HUMAN             Reviewed;        1184 AA.
AC   A6NCI4; A4QMU8; A6NNC0; Q6UTX4; Q6ZQZ9; Q8IUY6; Q8N9W1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 3.
DT   13-FEB-2019, entry version 87.
DE   RecName: Full=von Willebrand factor A domain-containing protein 3A;
DE   Flags: Precursor;
GN   Name=VWA3A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RA   Zhou G., Yu R., Li H., Ke R., Zheng G., Shen C., Zhong G., Lin L.,
RA   Yang S.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP   ILE-657.
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 392-1184.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=A6NCI4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NCI4-2; Sequence=VSP_032320;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=A6NCI4-3; Sequence=VSP_032318;
CC         Note=No experimental confirmation available.;
CC       Name=4;
CC         IsoId=A6NCI4-4; Sequence=VSP_032319, VSP_032321;
CC         Note=No experimental confirmation available.;
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DR   EMBL; AY360464; AAQ62968.1; -; mRNA.
DR   EMBL; AK093467; BAC04176.1; -; mRNA.
DR   EMBL; AK128606; BAC87526.1; -; mRNA.
DR   EMBL; AC009019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471249; EAW50598.1; -; Genomic_DNA.
DR   EMBL; BC038400; AAH38400.1; -; mRNA.
DR   EMBL; BC109295; AAI09296.1; -; mRNA.
DR   CCDS; CCDS45441.1; -. [A6NCI4-1]
DR   RefSeq; NP_775886.3; NM_173615.4. [A6NCI4-1]
DR   UniGene; Hs.10697; -.
DR   ProteinModelPortal; A6NCI4; -.
DR   IntAct; A6NCI4; 1.
DR   STRING; 9606.ENSP00000374049; -.
DR   iPTMnet; A6NCI4; -.
DR   PhosphoSitePlus; A6NCI4; -.
DR   BioMuta; VWA3A; -.
DR   jPOST; A6NCI4; -.
DR   PaxDb; A6NCI4; -.
DR   PRIDE; A6NCI4; -.
DR   ProteomicsDB; 833; -.
DR   ProteomicsDB; 834; -. [A6NCI4-2]
DR   ProteomicsDB; 835; -. [A6NCI4-3]
DR   ProteomicsDB; 836; -. [A6NCI4-4]
DR   Ensembl; ENST00000389398; ENSP00000374049; ENSG00000175267. [A6NCI4-1]
DR   Ensembl; ENST00000563755; ENSP00000456513; ENSG00000175267. [A6NCI4-4]
DR   GeneID; 146177; -.
DR   KEGG; hsa:146177; -.
DR   UCSC; uc010bxe.2; human. [A6NCI4-1]
DR   CTD; 146177; -.
DR   DisGeNET; 146177; -.
DR   EuPathDB; HostDB:ENSG00000175267.14; -.
DR   GeneCards; VWA3A; -.
DR   HGNC; HGNC:27088; VWA3A.
DR   HPA; HPA041696; -.
DR   HPA; HPA042044; -.
DR   neXtProt; NX_A6NCI4; -.
DR   OpenTargets; ENSG00000175267; -.
DR   PharmGKB; PA162408933; -.
DR   eggNOG; ENOG410IGU6; Eukaryota.
DR   eggNOG; ENOG410XS5K; LUCA.
DR   GeneTree; ENSGT00940000159290; -.
DR   HOVERGEN; HBG108660; -.
DR   InParanoid; A6NCI4; -.
DR   OMA; CSSQEWV; -.
DR   OrthoDB; 580729at2759; -.
DR   PhylomeDB; A6NCI4; -.
DR   TreeFam; TF328978; -.
DR   ChiTaRS; VWA3A; human.
DR   GenomeRNAi; 146177; -.
DR   PRO; PR:A6NCI4; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000175267; Expressed in 142 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; A6NCI4; baseline and differential.
DR   Genevisible; A6NCI4; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 3.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13768; VWA_3; 3.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 3.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Complete proteome; Glycoprotein;
KW   Polymorphism; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25   1184       von Willebrand factor A domain-containing
FT                                protein 3A.
FT                                /FTId=PRO_0000324623.
FT   DOMAIN      511    708       VWFA 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00219}.
FT   DOMAIN      959   1131       VWFA 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00219}.
FT   COILED      333    357       {ECO:0000255}.
FT   CARBOHYD    709    709       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ       1    922       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_032318.
FT   VAR_SEQ       1    898       Missing (in isoform 4).
FT                                {ECO:0000303|Ref.1}.
FT                                /FTId=VSP_032319.
FT   VAR_SEQ       7    382       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_032320.
FT   VAR_SEQ     899    945       KHCSIFPSVEIHGVVRHIQWTPREMEVYIRHLEKVLRRYVQ
FT                                RLQWLL -> MEVYIRHLEKVLRRYVQRLQWLLSGPVLCSR
FT                                TWYRQSMDRGVMMTAA (in isoform 4).
FT                                {ECO:0000303|Ref.1}.
FT                                /FTId=VSP_032321.
FT   VARIANT     464    464       T -> I (in dbSNP:rs1369695824).
FT                                /FTId=VAR_059738.
FT   VARIANT     657    657       T -> I (in dbSNP:rs1105929).
FT                                {ECO:0000269|PubMed:14702039}.
FT                                /FTId=VAR_057020.
FT   VARIANT    1165   1165       Q -> P (in dbSNP:rs16972517).
FT                                /FTId=VAR_057021.
FT   CONFLICT    885    885       N -> S (in Ref. 5; AAH38400).
FT                                {ECO:0000305}.
FT   CONFLICT   1005   1005       F -> L (in Ref. 1; AAQ62968, 2; BAC04176/
FT                                BAC87526, 4; EAW50598 and 5; AAH38400/
FT                                AAI09296). {ECO:0000305}.
SQ   SEQUENCE   1184 AA;  134020 MW;  1CA57332FA8879F0 CRC64;
     MKKYRKISIG CFAMATQTSH VFHGQENMFL ENHCIRRNTG RDSKKPLKQK NMNGLGQNSD
     NGLLVTHVNQ TQDLLRLQGS ETQSSDWEDS EDWLSAHSLK CQKLTLADLI SQGTEVLEEG
     TNVVQKICFS TQIIRHFESK LSDTIEVYQE RIQWLTENSK KAFGLIKGAR VSILIDVSAI
     SSGPQKEEFQ KDLMSLIDEQ LSHKEKLFVL SFGTNAGSLW PDPMEVSAST LQELKLWVKT
     LQPDGGSNLL QALKKIFTLK GLDSLVAIMR SCPDQPSEIL SDYIQQSTMG RDLIIHFITY
     RCDDQMPPAV LKNLAEAVRG YYHCYSPKME HYTSRDMDEL LAEIQKAQSL LSHVQALQHS
     SPCEALTCTM EEISTEITNG PLISLLPKPP KHDAPLTIEF PNLDKTSAEW LKVNGLKAKK
     LSLYQVLAPN AFSPVEEFVP ILQKTVSSTI HEKAMIQFEW HDGTVKNIHV DPPFLYKYQQ
     QLSRAMRMYE RRIEWLSLAS RRIWGTVCEK RVVVLLDISA TNSMYIIHIQ HSLRLLLEEQ
     LSNKDCFNLI AFGSTIESWR PEMVPVSHNN LQSAWRWALN LRCRGSRNVL SALRKAVEVD
     FKDKDKHQSQ GIYLFTGGIP DQDMPTLSAY MAEACGGCDL QLNVCLFYVG EPKMDTTPPA
     RYASHTDTAA AYKEVTRAAG GRFHWFGDTG IYESDDINSI MSEMEKALNY SQKCAFLMAS
     LKNHSGKVLG SSALPKEKPK TLQLRSQPKK LCPPRPTVPL GARMSIKDDP DREKSPPLKS
     LKWRPLSSRV GISPAAAQPT KEGMMELRRK TKSREAETSL LLFYTEKGND VGSVYKKYPQ
     GRGLRRTSSS IDLPRKDTVC SSQEWVAKYG LKKLKLEISR CMGPNCTHQK SGQRSASAKH
     CSIFPSVEIH GVVRHIQWTP REMEVYIRHL EKVLRRYVQR LQWLLSGSRR LFGTVLESKV
     CILLDTSGSM GPYLQQVKTE LVLLIWEQLR KCCDSFNLLS FAESFQSWQD TLVETTDAAC
     HEAMQWVTHL QAQGSTSILQ ALLKAFSFHD LEGLYLLTDG KPDTSCSLVL NEVQKLREKR
     DVKVHTISLN CSDRAAVEFL RKLASFTGGR YHCPVGEDTL SKIHSLLTKG FINEKDPTLP
     PFEGDDLRIL AQEITKARSF LWQAQSFRSQ LQKKNDAEPK VTLS
//