ID   A6NC89_HUMAN            Unreviewed;      1207 AA.
AC   A6NC89;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 2.
DT   16-JAN-2019, entry version 110.
DE   SubName: Full=Contactin-associated protein-like 3 {ECO:0000313|Ensembl:ENSP00000366884};
GN   Name=CNTNAP3 {ECO:0000313|Ensembl:ENSP00000366884};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366884, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000366884, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000366884}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AL162501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A6NC89; -.
DR   EPD; A6NC89; -.
DR   jPOST; A6NC89; -.
DR   MaxQB; A6NC89; -.
DR   PeptideAtlas; A6NC89; -.
DR   PRIDE; A6NC89; -.
DR   Ensembl; ENST00000377656; ENSP00000366884; ENSG00000106714.
DR   UCSC; uc004abj.3; human.
DR   EuPathDB; HostDB:ENSG00000106714.17; -.
DR   HGNC; HGNC:13834; CNTNAP3.
DR   OpenTargets; ENSG00000106714; -.
DR   eggNOG; KOG3516; Eukaryota.
DR   eggNOG; ENOG410XPHG; LUCA.
DR   GeneTree; ENSGT00940000160228; -.
DR   HOVERGEN; HBG057718; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000106714; Expressed in 90 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; A6NC89; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR028873; CASPR3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR43925:SF6; PTHR43925:SF6; 2.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00282; LamG; 4.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A6NC89,
KW   ECO:0000213|PeptideAtlas:A6NC89};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1207       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002700209.
FT   TRANSMEM   1164   1185       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       31    177       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DOMAIN      183    364       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      370    545       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      547    584       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      583    634       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   DOMAIN      934   1122       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
SQ   SEQUENCE   1207 AA;  132154 MW;  7AEAC840961AC5EB CRC64;
     MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL SSSHGPGFSR
     LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY GSSDWVTSYL LMFSDGGRNW
     KQYRREESIW GFPGNTNADS VVHYRLQPPF EARFLRFLPL AWNPRGRIGM RIEVYGCAYK
     SEVVYFDGQS ALLYRLDKKP LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK
     LVFFLNSGNA KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
     SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH KPQILMMGNV
     SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT WNRAGHLLFG ELRRGSGSFV
     LFLKDGKLKL SLFQPGQSPR NVTAGAGLND GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA
     VLIDSGDTYY FGGCLDNSSG SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL
     QIDSCGITDR CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
     PSGLYYIDAD GSGPLGPFLV YCNMTDAAWT VVQHGGPDAV TLRGAPSGHP RSAVSFAYAA
     GAGQLRSAVN LAERCEQRLA LRCGTARRPD SRDGTPLSWW VGRTNETHTS WGGSLPDAQK
     CTCGLEGNCI DSQYYCNCDA GRNEWTSDTI VLSQKEHLPV TQIVMTDAGR PHSEAAYTLG
     PLLCRGDQSF WNSASFNTET SYLHFPAFHG ELTADVCFFF KTTVSSGVFM ENLGITDFIR
     IELRAPTEVT FSFDVGNGPC EVTVQSPTPF NDNQWHHVRA ERNVKGASLQ VDQLPQKMQP
     APADGHVRLQ LNSQLFIEIS AYFATGSSMT YHFQEHYTLS ENSSSLVSSL HRDVTLTREM
     ITLSFRTTRT PSLLLYVSSF YEEYLSVILA NNGSLQIRYK LDRHQNPDAF TFDFKNMADG
     QLHQVKINRE EAVVMVEVNQ STKKQVILSS GTEFNAVKSL ILGKVLEAAG ADPDTRRAAT
     SGFTGCLSAV RFGRAAPLKA ALRPSGPSRV TVRGHVAPMA RCAAGAASGS PARELAPRLA
     GGAGRSGPAD EGEPLVNADR RDSAVIGGVI AVVIFILLCI TAIAIRIYQQ RKLRKENESK
     VSKKEEC
//