ID   PINLY_HUMAN             Reviewed;         204 AA.
AC   A6NC86; B7Z457; O95053;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 3.
DT   16-JAN-2019, entry version 82.
DE   RecName: Full=phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein;
DE   Flags: Precursor;
GN   Name=PINLYP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=A6NC86-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6NC86-2; Sequence=VSP_044189;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=A6NC86-3; Sequence=VSP_044189, VSP_044190;
CC         Note=No experimental confirmation available. Ref.1 (BAH12443)
CC         sequence is in conflict in position: 6:H->R. {ECO:0000305};
CC       Name=4;
CC         IsoId=A6NC86-4; Sequence=VSP_044188;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the CNF-like-inhibitor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC99796.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AK296854; BAH12443.1; -; mRNA.
DR   EMBL; AC006276; AAC99796.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L34079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC071811; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS58667.1; -. [A6NC86-4]
DR   CCDS; CCDS74385.1; -. [A6NC86-1]
DR   RefSeq; NP_001180550.1; NM_001193621.1. [A6NC86-1]
DR   RefSeq; NP_001180551.1; NM_001193622.1. [A6NC86-4]
DR   RefSeq; NP_001308053.1; NM_001321124.1. [A6NC86-4]
DR   RefSeq; XP_011525272.1; XM_011526970.2. [A6NC86-2]
DR   RefSeq; XP_011525273.1; XM_011526971.2. [A6NC86-4]
DR   UniGene; Hs.22049; -.
DR   ProteinModelPortal; A6NC86; -.
DR   STRING; 9606.ENSP00000469886; -.
DR   iPTMnet; A6NC86; -.
DR   PhosphoSitePlus; A6NC86; -.
DR   BioMuta; PINLYP; -.
DR   PaxDb; A6NC86; -.
DR   PRIDE; A6NC86; -.
DR   ProteomicsDB; 808; -.
DR   Ensembl; ENST00000562255; ENSP00000457623; ENSG00000234465. [A6NC86-4]
DR   Ensembl; ENST00000562365; ENSP00000456310; ENSG00000234465. [A6NC86-4]
DR   Ensembl; ENST00000569031; ENSP00000457369; ENSG00000234465. [A6NC86-4]
DR   Ensembl; ENST00000599207; ENSP00000469886; ENSG00000234465. [A6NC86-1]
DR   Ensembl; ENST00000612042; ENSP00000479240; ENSG00000234465. [A6NC86-2]
DR   GeneID; 390940; -.
DR   KEGG; hsa:390940; -.
DR   UCSC; uc002owu.3; human. [A6NC86-1]
DR   CTD; 390940; -.
DR   EuPathDB; HostDB:ENSG00000234465.10; -.
DR   GeneCards; PINLYP; -.
DR   HGNC; HGNC:44206; PINLYP.
DR   HPA; HPA061218; -.
DR   neXtProt; NX_A6NC86; -.
DR   OpenTargets; ENSG00000234465; -.
DR   eggNOG; ENOG410IG64; Eukaryota.
DR   eggNOG; ENOG410Y3IY; LUCA.
DR   GeneTree; ENSGT00730000111229; -.
DR   HOGENOM; HOG000060192; -.
DR   HOVERGEN; HBG108748; -.
DR   InParanoid; A6NC86; -.
DR   OMA; KFATRGC; -.
DR   OrthoDB; 1485195at2759; -.
DR   PhylomeDB; A6NC86; -.
DR   GenomeRNAi; 390940; -.
DR   PRO; PR:A6NC86; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000234465; Expressed in 153 organ(s), highest expression level in adenohypophysis.
DR   Genevisible; A6NC86; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR004126; PLipase_A2_inh.
DR   Pfam; PF02988; PLA2_inh; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    204       phospholipase A2 inhibitor and Ly6/PLAUR
FT                                domain-containing protein.
FT                                /FTId=PRO_0000332737.
FT   DOMAIN       27    117       UPAR/Ly6.
FT   DISULFID     29     53       {ECO:0000250}.
FT   DISULFID     32     39       {ECO:0000250}.
FT   DISULFID     46     74       {ECO:0000250}.
FT   DISULFID     80    101       {ECO:0000250}.
FT   DISULFID    102    107       {ECO:0000250}.
FT   DISULFID    126    151       {ECO:0000250}.
FT   DISULFID    144    172       {ECO:0000250}.
FT   VAR_SEQ       1     88       Missing (in isoform 4).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_044188.
FT   VAR_SEQ       1      1       M -> MWVQTHPSSASYKSWGPGTADTHTM (in
FT                                isoform 2 and isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_044189.
FT   VAR_SEQ      63    204       KGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQ
FT                                SDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHC
FT                                TGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAE
FT                                VPTGTNVLFLHHIECTHSP -> SKRMWPGTWWGGGVYLQG
FT                                GRDYHAEGGSSRFSRRERGKKSVESRKEGKTIMRWREQK
FT                                (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_044190.
SQ   SEQUENCE   204 AA;  21926 MW;  9F49DFAF0AFB9868 CRC64;
     MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA
     TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT
     ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT
     KPGAEVPTGT NVLFLHHIEC THSP
//