ID   A6NC48_HUMAN            Unreviewed;       333 AA.
AC   A6NC48;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   16-JAN-2019, entry version 79.
DE   SubName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 {ECO:0000313|Ensembl:ENSP00000371783};
GN   Name=BST1 {ECO:0000313|Ensembl:ENSP00000371783};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371783, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000371783, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000371783}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC005798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A6NC48; -.
DR   SMR; A6NC48; -.
DR   EPD; A6NC48; -.
DR   jPOST; A6NC48; -.
DR   MaxQB; A6NC48; -.
DR   PeptideAtlas; A6NC48; -.
DR   PRIDE; A6NC48; -.
DR   Ensembl; ENST00000382346; ENSP00000371783; ENSG00000109743.
DR   UCSC; uc062viq.1; human.
DR   EuPathDB; HostDB:ENSG00000109743.10; -.
DR   HGNC; HGNC:1118; BST1.
DR   OpenTargets; ENSG00000109743; -.
DR   eggNOG; ENOG410IP4Q; Eukaryota.
DR   eggNOG; ENOG4111W33; LUCA.
DR   GeneTree; ENSGT00390000017291; -.
DR   HOGENOM; HOG000293141; -.
DR   HOVERGEN; HBG097049; -.
DR   OMA; EPKGAYP; -.
DR   PhylomeDB; A6NC48; -.
DR   ChiTaRS; BST1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000109743; Expressed in 125 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; A6NC48; baseline and differential.
DR   GO; GO:0003953; F:NAD+ nucleosidase activity; IEA:InterPro.
DR   CDD; cd04759; Rib_hydrolase; 1.
DR   InterPro; IPR003193; ADP-ribosyl_cyclase.
DR   PANTHER; PTHR10912; PTHR10912; 1.
DR   Pfam; PF02267; Rib_hydrolayse; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A6NC48,
KW   ECO:0000213|PeptideAtlas:A6NC48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    333       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002700577.
SQ   SEQUENCE   333 AA;  37482 MW;  7C69ED3EF32BEDB5 CRC64;
     MAAQGCAASR LLQLLLQLLL LLLLLAAGGA RARWRGEGTS AHLRDIFLGR CAEYRALLSP
     EQRQIRNSRE PPVLHTTQNK NCTAIWEAFK VALDKDPCSV LPSDYDLFIN LSRHSIPRDK
     SLFWENSHLL VNSFADNTRR FMPLSDVLYG RVADFLSWCR QKNDSGLDYQ SCPTSEDCEN
     NPVDSFWKRA SIQYSKDSSG VIHVMLNGSE PTGAYPIKGF FADYEIPNLQ KEKITRIEIW
     VMHEIGGPNV ESCGEGSMKV LEKRLKDMGF QYSCINDYRP VKLLQCVDHS THPDCALKSA
     AAATQRKAPS LYTEQRAGLI IPLFLVLASR TQL
//