ID   CDHR4_HUMAN             Reviewed;         788 AA.
AC   A6H8M9; Q6UXT0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   13-FEB-2019, entry version 95.
DE   RecName: Full=Cadherin-related family member 4;
DE   AltName: Full=Cadherin-like protein 29;
DE   Flags: Precursor;
GN   Name=CDHR4; Synonyms=CDH29; ORFNames=UNQ9392/PRO34300;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       They preferentially interact with themselves in a homophilic
CC       manner in connecting cells; cadherins may thus contribute to the
CC       sorting of heterogeneous cell types (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6H8M9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6H8M9-2; Sequence=VSP_031552, VSP_031553;
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DR   EMBL; AY358221; AAQ88588.1; -; mRNA.
DR   EMBL; BC132756; AAI32757.1; -; mRNA.
DR   EMBL; BC146674; AAI46675.1; -; mRNA.
DR   CCDS; CCDS46829.1; -. [A6H8M9-1]
DR   RefSeq; NP_001007541.2; NM_001007540.3. [A6H8M9-1]
DR   UniGene; Hs.363312; -.
DR   ProteinModelPortal; A6H8M9; -.
DR   SMR; A6H8M9; -.
DR   STRING; 9606.ENSP00000391409; -.
DR   iPTMnet; A6H8M9; -.
DR   PhosphoSitePlus; A6H8M9; -.
DR   BioMuta; CDHR4; -.
DR   PaxDb; A6H8M9; -.
DR   PRIDE; A6H8M9; -.
DR   ProteomicsDB; 775; -.
DR   ProteomicsDB; 776; -. [A6H8M9-2]
DR   DNASU; 389118; -.
DR   Ensembl; ENST00000343366; ENSP00000341302; ENSG00000187492. [A6H8M9-2]
DR   Ensembl; ENST00000412678; ENSP00000391409; ENSG00000187492. [A6H8M9-1]
DR   GeneID; 389118; -.
DR   KEGG; hsa:389118; -.
DR   UCSC; uc003cxp.3; human. [A6H8M9-1]
DR   CTD; 389118; -.
DR   EuPathDB; HostDB:ENSG00000187492.8; -.
DR   GeneCards; CDHR4; -.
DR   HGNC; HGNC:34527; CDHR4.
DR   HPA; HPA076277; -.
DR   neXtProt; NX_A6H8M9; -.
DR   OpenTargets; ENSG00000187492; -.
DR   PharmGKB; PA165696944; -.
DR   eggNOG; ENOG410ISUN; Eukaryota.
DR   eggNOG; ENOG4110NJ5; LUCA.
DR   GeneTree; ENSGT00940000162824; -.
DR   HOGENOM; HOG000111287; -.
DR   InParanoid; A6H8M9; -.
DR   KO; K16504; -.
DR   OMA; VTKVSCW; -.
DR   OrthoDB; 371149at2759; -.
DR   PhylomeDB; A6H8M9; -.
DR   TreeFam; TF341878; -.
DR   GenomeRNAi; 389118; -.
DR   PRO; PR:A6H8M9; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000187492; Expressed in 68 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; A6H8M9; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   Pfam; PF00028; Cadherin; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 2.
DR   SUPFAM; SSF49313; SSF49313; 4.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Cell adhesion; Complete proteome;
KW   Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     16       {ECO:0000255}.
FT   CHAIN        17    788       Cadherin-related family member 4.
FT                                /FTId=PRO_0000319973.
FT   TOPO_DOM     17    686       Extracellular. {ECO:0000255}.
FT   TRANSMEM    687    707       Helical. {ECO:0000255}.
FT   TOPO_DOM    708    788       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      237    338       Cadherin 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      339    449       Cadherin 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      444    554       Cadherin 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      551    674       Cadherin 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   CARBOHYD    242    242       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     135    135       A -> GEARGSRQGGGRHGLSRSSLTSTLASWGNDSGARDS
FT                                HTWGSAVHSAPPRPRTPRSAGKPRTWDGG (in isoform
FT                                2). {ECO:0000303|PubMed:12975309,
FT                                ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031552.
FT   VAR_SEQ     136    788       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:12975309,
FT                                ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031553.
FT   VARIANT       5      5       R -> K (in dbSNP:rs13072748).
FT                                /FTId=VAR_039109.
SQ   SEQUENCE   788 AA;  85827 MW;  AAC5C9F6908DBF67 CRC64;
     MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP
     PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR
     DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP
     FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA
     QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG
     TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL
     TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG
     GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY
     TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV
     EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL
     QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS
     THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA
     PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT
     HTGARRWL
//