ID 5HT3E_HUMAN Reviewed; 456 AA. AC A5X5Y0; A8IKD7; E9PGF1; Q495G1; Q495G3; Q6V706; Q6V707; Q7Z6B2; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 10-JUL-2007, sequence version 1. DT 13-FEB-2019, entry version 115. DE RecName: Full=5-hydroxytryptamine receptor 3E; DE Short=5-HT3-E; DE Short=5-HT3E; DE AltName: Full=Serotonin receptor 3E; DE Flags: Precursor; GN Name=HTR3E; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY. RX PubMed=12801637; DOI=10.1016/S0378-1119(03)00503-1; RA Niesler B., Frank B., Kapeller J., Rappold G.A.; RT "Cloning, physical mapping and expression analysis of the human 5-HT3 RT serotonin receptor-like genes HTR3C, HTR3D and HTR3E."; RL Gene 310:101-111(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), AND TISSUE SPECIFICITY. RX PubMed=14597179; DOI=10.1016/S0378-1119(03)00803-5; RA Karnovsky A.M., Gotow L.F., McKinley D.D., Piechan J.L., Ruble C.L., RA Mills C.J., Schellin K.A.B., Slightom J.L., Fitzgerald L.R., RA Benjamin C.W., Roberds S.L.; RT "A cluster of novel serotonin receptor 3-like genes on human RT chromosome 3."; RL Gene 319:137-148(2003). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), SUBUNIT, AND RP SUBCELLULAR LOCATION. RX PubMed=17392525; DOI=10.1124/mol.106.032144; RA Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., RA Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.; RT "Characterization of the novel human serotonin receptor subunits 5- RT HT3C, 5-HT3D, and 5-HT3E."; RL Mol. Pharmacol. 72:8-17(2007). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING, RP SUBCELLULAR LOCATION, AND VARIANT THR-71. RX PubMed=19012743; DOI=10.1111/j.1471-4159.2008.05775.x; RA Holbrook J.D., Gill C.H., Zebda N., Spencer J.P., Leyland R., RA Rance K.H., Trinh H., Balmer G., Kelly F.M., Yusaf S.P., Courtenay N., RA Luck J., Rhodes A., Modha S., Moore S.E., Sanger G.J., Gunthorpe M.J.; RT "Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: RT evolution, distribution and function."; RL J. Neurochem. 108:384-396(2009). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. This receptor is CC a ligand-gated ion channel, which when activated causes fast, CC depolarizing responses. It is a cation-specific, but otherwise CC relatively nonselective, ion channel. CC -!- SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not CC functional as a homomeric complex. {ECO:0000269|PubMed:17392525}. CC -!- INTERACTION: CC P46098:HTR3A; NbExp=5; IntAct=EBI-11174612, EBI-9008743; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17392525, CC ECO:0000269|PubMed:19012743}; Multi-pass membrane protein CC {ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:19012743}. CC Note=Presumably retained within the endoplasmic reticulum unless CC complexed with HTR3A. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=A5X5Y0-1; Sequence=Displayed; CC Name=2; Synonyms=5-HT3c1; CC IsoId=A5X5Y0-2; Sequence=VSP_029804; CC Name=3; CC IsoId=A5X5Y0-3; Sequence=VSP_029803; CC Name=4; Synonyms=5-HT3c1 long; CC IsoId=A5X5Y0-4; Sequence=VSP_029803, VSP_029804; CC Name=5; Synonyms=HTR3E_V3; CC IsoId=A5X5Y0-6; Sequence=VSP_029803, VSP_029804, VSP_045573; CC -!- TISSUE SPECIFICITY: Expressed in adult colon and intestine. CC {ECO:0000269|PubMed:12801637, ECO:0000269|PubMed:14597179}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E CC sub-subfamily. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY349352; AAQ93476.1; -; mRNA. DR EMBL; AY349353; AAQ93477.1; -; mRNA. DR EMBL; AY159813; AAO38167.2; -; mRNA. DR EMBL; DQ644022; ABG35128.1; -; mRNA. DR EMBL; EU165354; ABW05298.1; -; mRNA. DR EMBL; AC131235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC101182; AAI01183.1; -; mRNA. DR EMBL; BC101183; AAI01184.1; -; mRNA. DR EMBL; BC101185; AAI01186.1; -; mRNA. DR CCDS; CCDS3251.1; -. [A5X5Y0-3] DR CCDS; CCDS58868.1; -. [A5X5Y0-1] DR CCDS; CCDS58869.1; -. [A5X5Y0-2] DR CCDS; CCDS58870.1; -. [A5X5Y0-4] DR CCDS; CCDS58871.1; -. [A5X5Y0-6] DR RefSeq; NP_001243542.1; NM_001256613.1. [A5X5Y0-1] DR RefSeq; NP_001243543.1; NM_001256614.1. [A5X5Y0-6] DR RefSeq; NP_872395.2; NM_182589.2. [A5X5Y0-3] DR RefSeq; NP_938055.1; NM_198313.2. [A5X5Y0-2] DR RefSeq; NP_938056.1; NM_198314.2. [A5X5Y0-4] DR UniGene; Hs.449179; -. DR ProteinModelPortal; A5X5Y0; -. DR SMR; A5X5Y0; -. DR BioGrid; 130056; 6. DR ComplexPortal; CPX-273; 5-hydroxytryptamine-3A/E receptor complex. DR IntAct; A5X5Y0; 1. DR STRING; 9606.ENSP00000335511; -. DR BindingDB; A5X5Y0; -. DR ChEMBL; CHEMBL2094132; -. DR DrugBank; DB01049; Ergoloid mesylate. DR DrugBank; DB00898; Ethanol. DR DrugBank; DB13025; Tiapride. DR iPTMnet; A5X5Y0; -. DR PhosphoSitePlus; A5X5Y0; -. DR BioMuta; HTR3E; -. DR PaxDb; A5X5Y0; -. DR PRIDE; A5X5Y0; -. DR ProteomicsDB; 750; -. DR ProteomicsDB; 751; -. [A5X5Y0-2] DR ProteomicsDB; 752; -. [A5X5Y0-3] DR ProteomicsDB; 753; -. [A5X5Y0-4] DR Ensembl; ENST00000335304; ENSP00000335511; ENSG00000186038. [A5X5Y0-3] DR Ensembl; ENST00000415389; ENSP00000401444; ENSG00000186038. [A5X5Y0-1] DR Ensembl; ENST00000425359; ENSP00000401900; ENSG00000186038. [A5X5Y0-2] DR Ensembl; ENST00000436361; ENSP00000395833; ENSG00000186038. [A5X5Y0-4] DR Ensembl; ENST00000440596; ENSP00000406050; ENSG00000186038. [A5X5Y0-6] DR GeneID; 285242; -. DR KEGG; hsa:285242; -. DR UCSC; uc003fml.5; human. [A5X5Y0-1] DR CTD; 285242; -. DR DisGeNET; 285242; -. DR EuPathDB; HostDB:ENSG00000186038.9; -. DR GeneCards; HTR3E; -. DR HGNC; HGNC:24005; HTR3E. DR HPA; HPA049764; -. DR MIM; 610123; gene. DR neXtProt; NX_A5X5Y0; -. DR OpenTargets; ENSG00000186038; -. DR PharmGKB; PA134900226; -. DR eggNOG; KOG3645; Eukaryota. DR eggNOG; ENOG410XQGR; LUCA. DR GeneTree; ENSGT00940000163899; -. DR HOGENOM; HOG000241519; -. DR HOVERGEN; HBG106638; -. DR InParanoid; A5X5Y0; -. DR KO; K04819; -. DR OMA; EFMDVDK; -. DR OrthoDB; 123230at2759; -. DR PhylomeDB; A5X5Y0; -. DR TreeFam; TF315605; -. DR Reactome; R-HSA-112314; Neurotransmitter receptors and postsynaptic signal transmission. DR GeneWiki; HTR3E; -. DR GenomeRNAi; 285242; -. DR PRO; PR:A5X5Y0; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000186038; Expressed in 7 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; A5X5Y0; baseline and differential. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0043005; C:neuron projection; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0045202; C:synapse; IBA:GO_Central. DR GO; GO:0022850; F:serotonin-gated cation-selective channel activity; IDA:CACAO. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central. DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central. DR GO; GO:0050877; P:nervous system process; IBA:GO_Central. DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Ion channel; Ion transport; KW Ligand-gated ion channel; Membrane; Polymorphism; Receptor; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; KW Transport. FT SIGNAL 1 25 {ECO:0000255}. FT CHAIN 26 456 5-hydroxytryptamine receptor 3E. FT /FTId=PRO_0000312294. FT TOPO_DOM 26 248 Extracellular. {ECO:0000255}. FT TRANSMEM 249 269 Helical; Name=1. {ECO:0000255}. FT TOPO_DOM 270 282 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 283 303 Helical; Name=2. {ECO:0000255}. FT TOPO_DOM 304 307 Extracellular. {ECO:0000255}. FT TRANSMEM 308 328 Helical; Name=3. {ECO:0000255}. FT TOPO_DOM 329 433 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 434 454 Helical; Name=4. {ECO:0000255}. FT TOPO_DOM 455 456 Extracellular. {ECO:0000255}. FT CARBOHYD 175 175 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 162 176 {ECO:0000250}. FT VAR_SEQ 1 22 MEGSWFHRKRFSFYLLLGFLLQ -> MLAFILSRATPRPAL FT GPLSYREHRVALLHLTHSMSTT (in isoform 3, FT isoform 4 and isoform 5). FT {ECO:0000303|PubMed:12801637, FT ECO:0000303|PubMed:14597179, FT ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17392525, FT ECO:0000303|PubMed:19012743}. FT /FTId=VSP_029803. FT VAR_SEQ 79 93 Missing (in isoform 2, isoform 4 and FT isoform 5). {ECO:0000303|PubMed:14597179, FT ECO:0000303|PubMed:19012743}. FT /FTId=VSP_029804. FT VAR_SEQ 129 129 E -> ELCVSRAGQREVPSPGSHRDHSLPLGP (in FT isoform 5). FT {ECO:0000303|PubMed:19012743}. FT /FTId=VSP_045573. FT VARIANT 71 71 A -> T (in dbSNP:rs7627615). FT {ECO:0000269|PubMed:19012743}. FT /FTId=VAR_037481. FT VARIANT 430 430 A -> T (in dbSNP:rs13324468). FT /FTId=VAR_037482. FT CONFLICT 44 44 A -> T (in Ref. 6; AAI01183/AAI01184). FT {ECO:0000305}. SQ SEQUENCE 456 AA; 51438 MW; 4BFA6561BA309E83 CRC64; MEGSWFHRKR FSFYLLLGFL LQGRGVTFTI NCSGFGQHGA DPTALNSVFN RKPFRPVTNI SVPTQVNISF AMSAILDVNE QLHLLSSFLW LEMVWDNPFI SWNPEECEGI TKMSMAAKNL WLPDIFIIEL MDVDKTPKGL TAYVSNEGRI RYKKPMKVDS ICNLDIFYFP FDQQNCTLTF SSFLYTVDSM LLDMEKEVWE ITDASRNILQ THGEWELLGL SKATAKLSRG GNLYDQIVFY VAIRRRPSLY VINLLVPSGF LVAIDALSFY LPVKSGNRVP FKITLLLGYN VFLLMMSDLL PTSGTPLIGV YFALCLSLMV GSLLETIFIT HLLHVATTQP PPLPRWLHSL LLHCNSPGRC CPTAPQKENK GPGLTPTHLP GVKEPEVSAG QMPGPAEAEL TGGSEWTRAQ REHEAQKQHS VELWLQFSHA MDAMLFRLYL LFMASSIITV ICLWNT //