ID   PRS37_HUMAN             Reviewed;         235 AA.
AC   A4D1T9; B2RPB5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   16-JAN-2019, entry version 88.
DE   RecName: Full=Probable inactive serine protease 37 {ECO:0000305};
DE   AltName: Full=Probable inactive trypsin-X2;
DE   Flags: Precursor;
GN   Name=PRSS37 {ECO:0000312|HGNC:HGNC:29211}; Synonyms=TRYX2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INVOLVEMENT IN
RP   UNEXPLAINED MALE INFERTILITY.
RX   PubMed=27649891; DOI=10.1093/abbs/gmw096;
RA   Liu J., Shen C., Fan W., Chen Y., Zhang A., Feng Y., Li Z., Kuang Y.,
RA   Wang Z.;
RT   "Low levels of PRSS37 protein in sperm are associated with many cases
RT   of unexplained male infertility.";
RL   Acta Biochim. Biophys. Sin. 48:1058-1065(2016).
CC   -!- FUNCTION: Plays a role in male fertility (By similarity). May have
CC       a role in sperm migration or binding to zona-intact eggs (By
CC       similarity). Involved in the activation of the proacrosin/acrosin
CC       system (PubMed:27649891). {ECO:0000250|UniProtKB:Q9DAA4,
CC       ECO:0000269|PubMed:27649891}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       acrosome {ECO:0000269|PubMed:27649891}. Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Testis-specific (PubMed:27649891). Expressed
CC       in spermatids (at protein level) (PubMed:27649891).
CC       {ECO:0000269|PubMed:27649891}.
CC   -!- DISEASE: Note=Patients with unexplained male infertility (UMI)
CC       show a decrease in the number of sperm cells compared to fertile
CC       men (PubMed:27649891). Sperm exhibit also abnormal activation of
CC       the proacrosin/acrosin system and premature proteolysis of ADAM2
CC       (PubMed:27649891). {ECO:0000269|PubMed:27649891}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- CAUTION: Although related to peptidase S1 family, lacks the
CC       conserved active Ser residue in position 192 which is replaced by
CC       an Ala, suggesting that it has no protease activity. Lacks also
CC       metal binding sites Glu in position 67 which is replaced by Asn
CC       and Asn in position 69 which is replaced by Lys. {ECO:0000305}.
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DR   EMBL; CH236950; EAL24014.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83986.1; -; Genomic_DNA.
DR   EMBL; BC137353; AAI37354.1; -; mRNA.
DR   EMBL; BC137354; AAI37355.1; -; mRNA.
DR   CCDS; CCDS34764.1; -.
DR   RefSeq; NP_001008271.2; NM_001008270.2.
DR   UniGene; Hs.98947; -.
DR   ProteinModelPortal; A4D1T9; -.
DR   BioGrid; 126449; 11.
DR   STRING; 9606.ENSP00000297767; -.
DR   MEROPS; S01.989; -.
DR   BioMuta; PRSS37; -.
DR   PaxDb; A4D1T9; -.
DR   PRIDE; A4D1T9; -.
DR   ProteomicsDB; 631; -.
DR   Ensembl; ENST00000350549; ENSP00000297767; ENSG00000165076.
DR   Ensembl; ENST00000438520; ENSP00000414461; ENSG00000165076.
DR   GeneID; 136242; -.
DR   KEGG; hsa:136242; -.
DR   UCSC; uc003vws.3; human.
DR   CTD; 136242; -.
DR   EuPathDB; HostDB:ENSG00000165076.13; -.
DR   GeneCards; PRSS37; -.
DR   HGNC; HGNC:29211; PRSS37.
DR   HPA; HPA020541; -.
DR   neXtProt; NX_A4D1T9; -.
DR   OpenTargets; ENSG00000165076; -.
DR   PharmGKB; PA165618277; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000161483; -.
DR   HOGENOM; HOG000251820; -.
DR   InParanoid; A4D1T9; -.
DR   OMA; RYWNYSH; -.
DR   OrthoDB; 1314811at2759; -.
DR   PhylomeDB; A4D1T9; -.
DR   TreeFam; TF331065; -.
DR   GenomeRNAi; 136242; -.
DR   PRO; PR:A4D1T9; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000165076; Expressed in 63 organ(s), highest expression level in left testis.
DR   ExpressionAtlas; A4D1T9; baseline and differential.
DR   Genevisible; A4D1T9; HS.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007339; P:binding of sperm to zona pellucida; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; IMP:UniProtKB.
DR   GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0051604; P:protein maturation; ISS:UniProtKB.
DR   GO; GO:0070613; P:regulation of protein processing; IMP:UniProtKB.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasmic vesicle; Disulfide bond; Fertilization;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    235       Probable inactive serine protease 37.
FT                                /FTId=PRO_0000326070.
FT   DOMAIN       20    233       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   DISULFID     40     56       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    131    198       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    163    177       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   VARIANT     119    119       T -> P (in dbSNP:rs12669721).
FT                                /FTId=VAR_039985.
SQ   SEQUENCE   235 AA;  26445 MW;  ECEED5C51E94E3B5 CRC64;
     MKYVFYLGVL AGTFFFADSS VQKEDPAPYL VYLKSHFNPC VGVLIKPSWV LAPAHCYLPN
     LKVMLGNFKS RVRDGTEQTI NPIQIVRYWN YSHSAPQDDL MLIKLAKPAM LNPKVQPLTL
     ATTNVRPGTV CLLSGLDWSQ ENSGRHPDLR QNLEAPVMSD RECQKTEQGK SHRNSLCVKF
     VKVFSRIFGE VAVATVICKD KLQGIEVGHF MGGDVGIYTN VYKYVSWIEN TAKDK
//