ID   CPED1_HUMAN             Reviewed;        1026 AA.
AC   A4D0V7; A8K1R3; Q6UXT1; Q86T76; Q86T84; Q8N2T5; Q96NC9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   13-FEB-2019, entry version 92.
DE   RecName: Full=Cadherin-like and PC-esterase domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=CPED1; Synonyms=C7orf58; ORFNames=UNQ9432/PRO34713;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP   GLY-551.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP   GLY-551 AND GLY-708.
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   GLY-708.
RC   TISSUE=Spinal cord;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-802 (ISOFORM 2), AND
RP   VARIANT GLY-551.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A4D0V7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A4D0V7-2; Sequence=VSP_031140, VSP_031141;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the PC-esterase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH30538.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AY358220; AAQ88587.1; -; mRNA.
DR   EMBL; AK055624; BAB70974.1; -; mRNA.
DR   EMBL; AK289978; BAF82667.1; -; mRNA.
DR   EMBL; AL832619; CAD89961.1; -; mRNA.
DR   EMBL; AL832638; CAD89953.1; -; mRNA.
DR   EMBL; CH236947; EAL24348.1; -; Genomic_DNA.
DR   EMBL; BC030538; AAH30538.1; ALT_INIT; mRNA.
DR   CCDS; CCDS34739.1; -. [A4D0V7-1]
DR   CCDS; CCDS47690.1; -. [A4D0V7-2]
DR   RefSeq; NP_001099003.1; NM_001105533.1. [A4D0V7-2]
DR   RefSeq; NP_079189.4; NM_024913.4. [A4D0V7-1]
DR   UniGene; Hs.189652; -.
DR   ProteinModelPortal; A4D0V7; -.
DR   BioGrid; 123041; 1.
DR   IntAct; A4D0V7; 1.
DR   STRING; 9606.ENSP00000309772; -.
DR   iPTMnet; A4D0V7; -.
DR   PhosphoSitePlus; A4D0V7; -.
DR   BioMuta; CPED1; -.
DR   EPD; A4D0V7; -.
DR   MaxQB; A4D0V7; -.
DR   PaxDb; A4D0V7; -.
DR   PRIDE; A4D0V7; -.
DR   ProteomicsDB; 598; -.
DR   ProteomicsDB; 599; -. [A4D0V7-2]
DR   DNASU; 79974; -.
DR   Ensembl; ENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
DR   Ensembl; ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
DR   GeneID; 79974; -.
DR   KEGG; hsa:79974; -.
DR   UCSC; uc003vjq.5; human. [A4D0V7-1]
DR   CTD; 79974; -.
DR   DisGeNET; 79974; -.
DR   EuPathDB; HostDB:ENSG00000106034.17; -.
DR   GeneCards; CPED1; -.
DR   H-InvDB; HIX0201130; -.
DR   HGNC; HGNC:26159; CPED1.
DR   HPA; HPA012058; -.
DR   neXtProt; NX_A4D0V7; -.
DR   OpenTargets; ENSG00000106034; -.
DR   PharmGKB; PA162380636; -.
DR   eggNOG; ENOG410IEF4; Eukaryota.
DR   eggNOG; ENOG4110TQ2; LUCA.
DR   GeneTree; ENSGT00390000015216; -.
DR   HOVERGEN; HBG095603; -.
DR   InParanoid; A4D0V7; -.
DR   OMA; EGLCQII; -.
DR   OrthoDB; 1168500at2759; -.
DR   PhylomeDB; A4D0V7; -.
DR   TreeFam; TF332741; -.
DR   ChiTaRS; CPED1; human.
DR   GeneWiki; FLJ21986; -.
DR   GenomeRNAi; 79974; -.
DR   PRO; PR:A4D0V7; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106034; Expressed in 200 organ(s), highest expression level in cauda epididymis.
DR   ExpressionAtlas; A4D0V7; baseline and differential.
DR   Genevisible; A4D0V7; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR   InterPro; IPR025883; Cadherin-like_b_sandwich.
DR   Pfam; PF12733; Cadherin-like; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Glycoprotein; Polymorphism;
KW   Reference proteome; Signal.
FT   SIGNAL        1     34       {ECO:0000255}.
FT   CHAIN        35   1026       Cadherin-like and PC-esterase domain-
FT                                containing protein 1.
FT                                /FTId=PRO_0000317732.
FT   CARBOHYD    251    251       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    404    404       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    413    413       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    737    737       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    791    791       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    985    985       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     771    783       ILFIGDSTNRGIM -> LGVDVQRVPRSRN (in
FT                                isoform 2). {ECO:0000303|PubMed:12975309,
FT                                ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031140.
FT   VAR_SEQ     784   1026       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:12975309,
FT                                ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031141.
FT   VARIANT     326    326       I -> T (in dbSNP:rs17143165).
FT                                /FTId=VAR_038664.
FT   VARIANT     551    551       A -> G (in dbSNP:rs41281692).
FT                                {ECO:0000269|PubMed:12975309,
FT                                ECO:0000269|PubMed:14702039,
FT                                ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_038665.
FT   VARIANT     708    708       E -> G (in dbSNP:rs35793694).
FT                                {ECO:0000269|PubMed:14702039,
FT                                ECO:0000269|PubMed:17974005}.
FT                                /FTId=VAR_038666.
FT   VARIANT     949    949       K -> T (in dbSNP:rs798911).
FT                                /FTId=VAR_038667.
FT   CONFLICT    173    173       C -> R (in Ref. 3; CAD89961).
FT                                {ECO:0000305}.
FT   CONFLICT    186    186       E -> G (in Ref. 2; BAF82667).
FT                                {ECO:0000305}.
FT   CONFLICT    262    262       I -> T (in Ref. 3; CAD89961).
FT                                {ECO:0000305}.
FT   CONFLICT    641    641       K -> R (in Ref. 3; CAD89961).
FT                                {ECO:0000305}.
FT   CONFLICT    795    795       Q -> R (in Ref. 3; CAD89961).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1026 AA;  117491 MW;  7C3E91FAF7494440 CRC64;
     MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP HTSTETQASR
     CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI LYRPPFYSKT ELQLHQHILT
     QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW DLLICLSSKK AEGTPCISKE VMCQLGLHQK
     ANRLPEIQQP LCRKEGLCQI VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW
     KPGDWSREQL NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
     KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK TFHRCRFCFQ
     LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE FLLNDTFNFL FPNESSLSIF
     SEIFQRLYRS DVFKGENYQK ELNQCLSLEE INSIMTFIKE LGSLGQFQLL FPSTTPGIQS
     LMHEFYDVAN PVGNPGSVLT QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV
     PFDAIENKKA AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
     PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES PAHGETLITY
     KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ PISSDYIEAI LQSELKRCPS
     GDMKGQWIVP CLSCSDNRTC DWREITWQPH NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR
     GIMYYLIERL NETLQEWQKV HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH
     LLQRSRPLEN TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
     GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC GCHFHEVVKS
     KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP YHVRGPINQV CSEILLSRMC
     ANKRTM
//