ID   COLL1_HUMAN             Reviewed;         121 AA.
AC   A2RUU4; A7E2T6; B2RPE2; B5G4V2; B6ZDM9; Q5T9G1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   13-FEB-2019, entry version 93.
DE   RecName: Full=Colipase-like protein 1;
DE   Flags: Precursor;
GN   Name=CLPSL1; Synonyms=C6orf127;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Epididymis;
RX   PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA   Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA   Jin S.H., Zhang Y.L.;
RT   "Transcriptome analysis of a cDNA library from adult human
RT   epididymis.";
RL   DNA Res. 15:115-122(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|PROSITE-
CC       ProRule:PRU00674}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in epididymis, in the
CC       corpus region. {ECO:0000269|PubMed:18390568}.
CC   -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00674}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK41022.1; Type=Frameshift; Positions=120; Evidence={ECO:0000305};
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DR   EMBL; DQ823638; ABK41022.1; ALT_FRAME; mRNA.
DR   EMBL; AL157823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03849.1; -; Genomic_DNA.
DR   EMBL; BC133046; AAI33047.1; -; mRNA.
DR   EMBL; BC137392; AAI37393.1; -; mRNA.
DR   EMBL; BC150543; AAI50544.1; -; mRNA.
DR   EMBL; BC150544; AAI50545.1; -; mRNA.
DR   CCDS; CCDS43456.1; -.
DR   RefSeq; NP_001010886.1; NM_001010886.4.
DR   UniGene; Hs.131296; -.
DR   ProteinModelPortal; A2RUU4; -.
DR   SMR; A2RUU4; -.
DR   BioGrid; 131012; 12.
DR   iPTMnet; A2RUU4; -.
DR   PhosphoSitePlus; A2RUU4; -.
DR   BioMuta; CLPSL1; -.
DR   PaxDb; A2RUU4; -.
DR   PRIDE; A2RUU4; -.
DR   ProteomicsDB; 525; -.
DR   Ensembl; ENST00000373861; ENSP00000362968; ENSG00000204140.
DR   GeneID; 340204; -.
DR   KEGG; hsa:340204; -.
DR   UCSC; uc003old.5; human.
DR   CTD; 340204; -.
DR   EuPathDB; HostDB:ENSG00000204140.9; -.
DR   GeneCards; CLPSL1; -.
DR   H-InvDB; HIX0057777; -.
DR   HGNC; HGNC:21251; CLPSL1.
DR   HPA; HPA073155; -.
DR   neXtProt; NX_A2RUU4; -.
DR   OpenTargets; ENSG00000204140; -.
DR   PharmGKB; PA134984810; -.
DR   eggNOG; ENOG410JH15; Eukaryota.
DR   eggNOG; ENOG4111A1I; LUCA.
DR   GeneTree; ENSGT00510000049845; -.
DR   HOGENOM; HOG000111566; -.
DR   HOVERGEN; HBG104657; -.
DR   InParanoid; A2RUU4; -.
DR   OMA; LGLYNEC; -.
DR   OrthoDB; 1517288at2759; -.
DR   PhylomeDB; A2RUU4; -.
DR   TreeFam; TF336178; -.
DR   GenomeRNAi; 340204; -.
DR   PRO; PR:A2RUU4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000204140; Expressed in 48 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A2RUU4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0032094; P:response to food; IBA:GO_Central.
DR   CDD; cd00039; COLIPASE; 1.
DR   InterPro; IPR001981; Colipase.
DR   PANTHER; PTHR10041; PTHR10041; 1.
DR   PRINTS; PR00128; COLIPASE.
DR   SMART; SM00023; COLIPASE; 1.
DR   PROSITE; PS51342; COLIPASE_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Polymorphism; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    121       Colipase-like protein 1.
FT                                /FTId=PRO_0000337013.
FT   DISULFID     39     50       {ECO:0000255|PROSITE-ProRule:PRU00674}.
FT   DISULFID     45     61       {ECO:0000255|PROSITE-ProRule:PRU00674}.
FT   DISULFID     49     83       {ECO:0000255|PROSITE-ProRule:PRU00674}.
FT   DISULFID     71     91       {ECO:0000255|PROSITE-ProRule:PRU00674}.
FT   DISULFID     85    107       {ECO:0000255|PROSITE-ProRule:PRU00674}.
FT   VARIANT      15     15       F -> S (in dbSNP:rs34109614).
FT                                /FTId=VAR_043560.
FT   CONFLICT     92     92       I -> M (in Ref. 4; AAI50545).
FT                                {ECO:0000305}.
SQ   SEQUENCE   121 AA;  14057 MW;  D73C9F747B130656 CRC64;
     MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC QRAPDNCESH
     CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL SIAYGRCQKI GRQKLAKKMF
     F
//