ID   TMM89_HUMAN             Reviewed;         159 AA.
AC   A2RUT3;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   13-FEB-2019, entry version 71.
DE   RecName: Full=Transmembrane protein 89;
DE   Flags: Precursor;
GN   Name=TMEM89;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC133034; AAI33035.1; -; mRNA.
DR   EMBL; BC133036; AAI33037.1; -; mRNA.
DR   CCDS; CCDS33751.1; -.
DR   RefSeq; NP_001008270.1; NM_001008269.1.
DR   UniGene; Hs.631922; -.
DR   ProteinModelPortal; A2RUT3; -.
DR   BioGrid; 137028; 1.
DR   IntAct; A2RUT3; 1.
DR   PhosphoSitePlus; A2RUT3; -.
DR   BioMuta; TMEM89; -.
DR   PaxDb; A2RUT3; -.
DR   PRIDE; A2RUT3; -.
DR   ProteomicsDB; 524; -.
DR   Ensembl; ENST00000330862; ENSP00000329557; ENSG00000183396.
DR   GeneID; 440955; -.
DR   KEGG; hsa:440955; -.
DR   UCSC; uc011bbo.3; human.
DR   CTD; 440955; -.
DR   EuPathDB; HostDB:ENSG00000183396.3; -.
DR   GeneCards; TMEM89; -.
DR   HGNC; HGNC:32372; TMEM89.
DR   HPA; HPA053577; -.
DR   neXtProt; NX_A2RUT3; -.
DR   PharmGKB; PA142670742; -.
DR   eggNOG; ENOG410IYCM; Eukaryota.
DR   eggNOG; ENOG4111CPB; LUCA.
DR   GeneTree; ENSGT00390000005336; -.
DR   HOGENOM; HOG000154652; -.
DR   HOVERGEN; HBG100155; -.
DR   InParanoid; A2RUT3; -.
DR   OMA; TEPCGPW; -.
DR   OrthoDB; 1413701at2759; -.
DR   PhylomeDB; A2RUT3; -.
DR   TreeFam; TF336927; -.
DR   GenomeRNAi; 440955; -.
DR   PRO; PR:A2RUT3; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000183396; Expressed in 59 organ(s), highest expression level in left testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR028069; TMEM89.
DR   PANTHER; PTHR37869; PTHR37869; 1.
DR   Pfam; PF15098; TMEM89; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Membrane; Polymorphism; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25    159       Transmembrane protein 89.
FT                                /FTId=PRO_0000290067.
FT   TOPO_DOM     25     63       Extracellular. {ECO:0000255}.
FT   TRANSMEM     64     86       Helical. {ECO:0000255}.
FT   TOPO_DOM     87    159       Cytoplasmic. {ECO:0000255}.
FT   VARIANT      61     61       P -> T (in dbSNP:rs9834639).
FT                                /FTId=VAR_051450.
SQ   SEQUENCE   159 AA;  17572 MW;  D6B70549CE50DD13 CRC64;
     MLHVLASLPL LLLLVTSAST HAWSRPLWYQ VGLDLQPWGC QPKSVEGCRG GLSCPGYWLG
     PGASRIYPVA AVMITTTMLM ICRKILQGRR RSQATKGEHP QVTTEPCGPW KRRAPISDHT
     LLRGVLHMLD ALLVHIEGHL RHLATQRQIQ IKGTSTQSG
//