ID   TM213_HUMAN             Reviewed;         107 AA.
AC   A2RRL7; A4D1R3; C9JH49; C9JX41; C9K0P0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 2.
DT   13-FEB-2019, entry version 76.
DE   RecName: Full=Transmembrane protein 213;
DE   Flags: Precursor;
GN   Name=TMEM213;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=A2RRL7-1; Sequence=Displayed;
CC         Note=Gene prediction based on EST data.;
CC       Name=2;
CC         IsoId=A2RRL7-2; Sequence=VSP_039555;
CC         Note=Gene prediction based on EST data.;
CC       Name=3;
CC         IsoId=A2RRL7-3; Sequence=VSP_039556;
CC         Note=No experimental confirmation available.;
CC       Name=4;
CC         IsoId=A2RRL7-4; Sequence=VSP_039557;
CC         Note=Gene prediction based on EST data.;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI31698.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; AC018663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236950; EAL24042.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83898.1; -; Genomic_DNA.
DR   EMBL; BC131697; AAI31698.1; ALT_INIT; mRNA.
DR   CCDS; CCDS47722.1; -. [A2RRL7-1]
DR   RefSeq; NP_001078898.1; NM_001085429.1. [A2RRL7-1]
DR   RefSeq; XP_005250224.1; XM_005250167.3.
DR   UniGene; Hs.567729; -.
DR   ProteinModelPortal; A2RRL7; -.
DR   BioGrid; 127567; 7.
DR   STRING; 9606.ENSP00000390407; -.
DR   BioMuta; TMEM213; -.
DR   PaxDb; A2RRL7; -.
DR   PRIDE; A2RRL7; -.
DR   ProteomicsDB; 472; -.
DR   ProteomicsDB; 473; -. [A2RRL7-2]
DR   ProteomicsDB; 474; -. [A2RRL7-3]
DR   ProteomicsDB; 475; -. [A2RRL7-4]
DR   Ensembl; ENST00000397602; ENSP00000380727; ENSG00000214128. [A2RRL7-3]
DR   Ensembl; ENST00000413208; ENSP00000401570; ENSG00000214128. [A2RRL7-4]
DR   Ensembl; ENST00000442682; ENSP00000390407; ENSG00000214128. [A2RRL7-1]
DR   Ensembl; ENST00000458494; ENSP00000393891; ENSG00000214128. [A2RRL7-2]
DR   GeneID; 155006; -.
DR   KEGG; hsa:155006; -.
DR   UCSC; uc010lna.5; human. [A2RRL7-1]
DR   CTD; 155006; -.
DR   DisGeNET; 155006; -.
DR   EuPathDB; HostDB:ENSG00000214128.10; -.
DR   GeneCards; TMEM213; -.
DR   HGNC; HGNC:27220; TMEM213.
DR   HPA; HPA054059; -.
DR   neXtProt; NX_A2RRL7; -.
DR   OpenTargets; ENSG00000214128; -.
DR   PharmGKB; PA162406494; -.
DR   eggNOG; ENOG410J39B; Eukaryota.
DR   eggNOG; ENOG411196J; LUCA.
DR   GeneTree; ENSGT00390000014153; -.
DR   HOGENOM; HOG000154626; -.
DR   HOVERGEN; HBG095879; -.
DR   InParanoid; A2RRL7; -.
DR   OMA; CLNVDFC; -.
DR   OrthoDB; 1521865at2759; -.
DR   PhylomeDB; A2RRL7; -.
DR   TreeFam; TF336187; -.
DR   GenomeRNAi; 155006; -.
DR   PRO; PR:A2RRL7; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000214128; Expressed in 67 organ(s), highest expression level in kidney epithelium.
DR   Genevisible; A2RRL7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028121; TMEM213.
DR   PANTHER; PTHR36293; PTHR36293; 1.
DR   Pfam; PF15192; TMEM213; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Complete proteome; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    107       Transmembrane protein 213.
FT                                /FTId=PRO_0000337054.
FT   TOPO_DOM     28     70       Extracellular. {ECO:0000255}.
FT   TRANSMEM     71     91       Helical. {ECO:0000255}.
FT   TOPO_DOM     92    107       Cytoplasmic. {ECO:0000255}.
FT   VAR_SEQ      28     52       EASSSNSSSLTAHHPDPGTLEQCLN -> D (in
FT                                isoform 2). {ECO:0000305}.
FT                                /FTId=VSP_039555.
FT   VAR_SEQ      28     28       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_039556.
FT   VAR_SEQ      52    107       NVDFCPQAARCCRTGVDEYGWIAAAVGWSLWFLTLILLCVD
FT                                KLMKLTPDEPKDLQA -> RSGYLANLRGEADQLWKFCTVL
FT                                CFWESRRSSSRIALMREAEEWPGWRSSVELVG (in
FT                                isoform 4). {ECO:0000305}.
FT                                /FTId=VSP_039557.
SQ   SEQUENCE   107 AA;  11520 MW;  BDE87C507C11E0D3 CRC64;
     MQRLPAATRA TLILSLAFAS LHSACSAEAS SSNSSSLTAH HPDPGTLEQC LNVDFCPQAA
     RCCRTGVDEY GWIAAAVGWS LWFLTLILLC VDKLMKLTPD EPKDLQA
//