ID   A2IBA6_HUMAN            Unreviewed;       417 AA.
AC   A2IBA6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 96.
DE   SubName: Full=Lipase member H {ECO:0000313|Ensembl:ENSP00000396384};
DE   SubName: Full=Mutant lipase H {ECO:0000313|EMBL:ABM67094.1};
GN   Name=LIPH {ECO:0000313|Ensembl:ENSP00000396384};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABM67094.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000396384, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|EMBL:ABM67094.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17095700; DOI=10.1126/science.1133276;
RA   Kazantseva A., Goltsov A., Zinchenko R., Grigorenko A.P.,
RA   Abrukova A.V., Moliaka Y.K., Kirillov A.G., Guo Z., Lyle S.,
RA   Ginter E.K., Rogaev E.I.;
RT   "Human hair growth deficiency is linked to a genetic defect in the
RT   phospholipase gene LIPH.";
RL   Science 314:982-985(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000396384}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AC099661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF186228; ABM67094.1; -; mRNA.
DR   RefSeq; XP_016861341.1; XM_017005852.1.
DR   UniGene; Hs.68864; -.
DR   ESTHER; human-LIPH; Phospholipase.
DR   jPOST; A2IBA6; -.
DR   PRIDE; A2IBA6; -.
DR   Ensembl; ENST00000424591; ENSP00000396384; ENSG00000163898.
DR   GeneID; 200879; -.
DR   UCSC; uc010hyh.4; human.
DR   CTD; 200879; -.
DR   EuPathDB; HostDB:ENSG00000163898.9; -.
DR   HGNC; HGNC:18483; LIPH.
DR   OpenTargets; ENSG00000163898; -.
DR   GeneTree; ENSGT00940000156285; -.
DR   HOGENOM; HOG000234386; -.
DR   HOVERGEN; HBG080640; -.
DR   OrthoDB; 534956at2759; -.
DR   ChiTaRS; LIPH; human.
DR   GenomeRNAi; 200879; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000163898; Expressed in 129 organ(s), highest expression level in testis.
DR   ExpressionAtlas; A2IBA6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 2.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 2.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2IBA6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    417       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565290.
FT   DOMAIN       34    177       Lipase. {ECO:0000259|Pfam:PF00151}.
SQ   SEQUENCE   417 AA;  47202 MW;  B3AEAF22887D54F3 CRC64;
     MLRFYLFISL LCLSRSDAEE TCPSFTRLSF HSAVVGTGLN VRLMLYTRKN LTCAQTINSS
     AFGNLNVTKK TTFIVHGFRP TGSPPVWMDD LVKGLLSVED MNVVVVDWNR GATTLIYTHA
     SSKTRKVAMV LKEFIDQMLA EGASLDDIYM IGVSLGAHIS GFVGEMYDGW LGRITALGYK
     EPLGNIDFYP NGGLDQPGCP KTILGGFQYF KCDHQRSVYL YLSSLRESCT ITAYPCDSYQ
     DYRNGKCVSC GTSQKESCPL LGYYADNWKD HLRGKDPPMT KAFFDTAEES PFCMYHYFVD
     IITWNKNVRR GDITIKLRDK AGNTTESKIN HEPTTFQKYH QVSLLARFNQ DLDKVAAISL
     MFSTGSLIGP RYKLRILRMK LRSLAHPERP QLCRYDLVLM ENVETVFQPI LCPELQL
//