ID   A2ABN6_HUMAN            Unreviewed;        97 AA.
AC   A2ABN6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 2.
DT   05-DEC-2018, entry version 91.
DE   SubName: Full=Lysosomal thioesterase PPT2 {ECO:0000313|Ensembl:ENSP00000395456};
DE   SubName: Full=PPT2-EGFL8 readthrough (NMD candidate) {ECO:0000313|Ensembl:ENSP00000461909};
GN   Name=PPT2 {ECO:0000313|Ensembl:ENSP00000395456};
GN   Synonyms=PPT2-EGFL8 {ECO:0000313|Ensembl:ENSP00000461909};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395456, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000395456, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000395456}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000461909}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AL662884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ESTHER; human-PPT2; Palmitoyl-protein_thioesterase.
DR   MaxQB; A2ABN6; -.
DR   Ensembl; ENST00000436118; ENSP00000395456; ENSG00000221988.
DR   Ensembl; ENST00000583227; ENSP00000461909; ENSG00000258388.
DR   Ensembl; ENST00000585246; ENSP00000463570; ENSG00000258388.
DR   UCSC; uc063nou.1; human.
DR   EuPathDB; HostDB:ENSG00000221988.12; -.
DR   EuPathDB; HostDB:ENSG00000258388.7; -.
DR   GeneCards; PPT2-EGFL8; -.
DR   HGNC; HGNC:9326; PPT2.
DR   HGNC; HGNC:48343; PPT2-EGFL8.
DR   OpenTargets; ENSG00000221988; -.
DR   OpenTargets; ENSG00000258388; -.
DR   eggNOG; KOG2541; Eukaryota.
DR   eggNOG; COG1075; LUCA.
DR   GeneTree; ENSGT00940000155779; -.
DR   HOGENOM; HOG000264240; -.
DR   HOVERGEN; HBG019159; -.
DR   ChiTaRS; PPT2; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000221988; Expressed in 195 organ(s), highest expression level in secondary oocyte.
DR   ExpressionAtlas; A2ABN6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029058; AB_hydrolase.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2ABN6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28     97       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565234.
FT   TRANSMEM     58     80       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   97 AA;  10894 MW;  5B09701B152E06E3 CRC64;
     MLGLCGQRLP AAWVLLLLPF LPLLLLAAPA PHRASYKPVI VVHGLFDSSY SFRHLLEYIN
     EGALCAGLCF LSWMITTWIL SSPSPLHRWD SMETRTT
//