ID   A2ABF0_HUMAN            Unreviewed;       508 AA.
AC   A2ABF0;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 98.
DE   SubName: Full=cDNA FLJ39914 fis, clone SPLEN2018732, highly similar to MutS protein homolog 5 {ECO:0000313|EMBL:BAG53438.1};
GN   Name=MSH5 {ECO:0000313|Ensembl:ENSP00000379194};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379194, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379194, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:BAG53438.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAG53438.1};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3] {ECO:0000313|Ensembl:ENSP00000379194}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000391394}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AL662834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR925765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK097233; BAG53438.1; -; mRNA.
DR   UniGene; Hs.647011; -.
DR   jPOST; A2ABF0; -.
DR   MaxQB; A2ABF0; -.
DR   PRIDE; A2ABF0; -.
DR   Ensembl; ENST00000395853; ENSP00000379194; ENSG00000204410.
DR   Ensembl; ENST00000414412; ENSP00000391394; ENSG00000235222.
DR   Ensembl; ENST00000430216; ENSP00000398538; ENSG00000233345.
DR   Ensembl; ENST00000436004; ENSP00000398373; ENSG00000227314.
DR   Ensembl; ENST00000439816; ENSP00000403531; ENSG00000230293.
DR   Ensembl; ENST00000448169; ENSP00000400820; ENSG00000237333.
DR   UCSC; uc063ngs.1; human.
DR   EuPathDB; HostDB:ENSG00000204410.14; -.
DR   HGNC; HGNC:7328; MSH5.
DR   OpenTargets; ENSG00000204410; -.
DR   eggNOG; KOG0221; Eukaryota.
DR   eggNOG; COG0249; LUCA.
DR   GeneTree; ENSGT00550000074977; -.
DR   HOGENOM; HOG000231215; -.
DR   HOVERGEN; HBG001449; -.
DR   ChiTaRS; MSH5; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000204410; Expressed in 87 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; A2ABF0; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    508       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014565229.
FT   DOMAIN      340    356       DNA_MISMATCH_REPAIR_2.
FT                                {ECO:0000259|PROSITE:PS00486}.
SQ   SEQUENCE   508 AA;  56121 MW;  F1AC73E87B022DBC CRC64;
     MWPVLLFVFL SQTVYSALGL RDACRSLPQS IQLFRDIAQE FSDDLHHIAS LIGKVVDFEG
     SLAENRFTVL PNIDPEIDEK KRRLMGLPSF LTEVARKELE NLDSRIPSCS VIYIPLIGFL
     LSIPRLPSMV EASDFEINGL DFMFLSEEKL HYRSARTKEL DALLGDLHCE IRDQETLLMY
     QLQCQVLARA AVLTRVLDLA SRLDVLLALA SAARDYGYSR PRYSPQVLGV RIQNGRHPLM
     ELCARTFVPN STECGGDKGR VKVITGPNSS GKSIYLKQVG LITFMALVGS FVPAEEAEIG
     AVDAIFTRIH SCESISLGLS TFMIDLNQVA KAVNNATAQS LVLIDEFGKG TNTVDGLALL
     AAVLRHWLAR GPTCPHIFVA TNFLSLVQLQ LLPQGPLVQY LTMETCEDGN DLVFFYQVCE
     GVAKASHASH TAAQAGLPDK LVARGKEVSD LIRSGKPIKP VKDLLKKNQM ENCQTLVDKF
     MKLDLEDPNL DLNVFMSQEV LPAATSIL
//