ID A2ABE9_HUMAN Unreviewed; 333 AA. AC A2ABE9; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 16-JAN-2019, entry version 92. DE SubName: Full=MutS protein homolog 5 {ECO:0000313|Ensembl:ENSP00000394971}; DE Flags: Fragment; GN Name=MSH5 {ECO:0000313|Ensembl:ENSP00000394971}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000394971, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000394971, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000394971} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000396934} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662834; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR925765; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A2ABE9; -. DR MaxQB; A2ABE9; -. DR PRIDE; A2ABE9; -. DR Ensembl; ENST00000412201; ENSP00000407288; ENSG00000235222. DR Ensembl; ENST00000425344; ENSP00000404249; ENSG00000235569. DR Ensembl; ENST00000435942; ENSP00000411551; ENSG00000230293. DR Ensembl; ENST00000443665; ENSP00000396934; ENSG00000227314. DR Ensembl; ENST00000450148; ENSP00000394971; ENSG00000204410. DR UCSC; uc063ngo.1; human. DR EuPathDB; HostDB:ENSG00000204410.14; -. DR HGNC; HGNC:7328; MSH5. DR OpenTargets; ENSG00000204410; -. DR eggNOG; KOG0221; Eukaryota. DR eggNOG; COG0249; LUCA. DR GeneTree; ENSGT00550000074977; -. DR ChiTaRS; MSH5; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204410; Expressed in 87 organ(s), highest expression level in right testis. DR ExpressionAtlas; A2ABE9; baseline and differential. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:InterPro. DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp. DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core. DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf. DR Pfam; PF05192; MutS_III; 1. DR Pfam; PF05190; MutS_IV; 1. DR SMART; SM00533; MUTSd; 1. DR SUPFAM; SSF48334; SSF48334; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 333 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014565224. FT DOMAIN 86 333 MUTSd. {ECO:0000259|SMART:SM00533}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000394971}. FT NON_TER 333 333 {ECO:0000313|Ensembl:ENSP00000394971}. SQ SEQUENCE 333 AA; 38085 MW; 915E6B3539EE5EB1 CRC64; KILFLSSIIP FDCLLTVRAL GGLLKFLGRR RIGVELEDYN VSVPILGFKK FMLTHLVNID QDTYSVLQIF KSESHPSVYK VASGLKEGLS LFGILNRCHC KWGEKLLRLW FTRPTHDLGE LSSRLDVIQF FLLPQNLDMA QMLHRLLGHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA LGLRDACRSL PQSIQLFRDI AQEFSDDLHH IASLIGKVYL SPQVDFEGSL AENRFTVLPN IDPEIDEKKR RLMGLPSFLT EVARKELENL DSRIPSCSVI YIPLIGFLLS IPRLPSMVEA SDFEINGLDF MFLSEEKLHY RSARTKELDA LLG //