ID A2AAT8_HUMAN Unreviewed; 166 AA. AC A2AAT8; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 16-JAN-2019, entry version 79. DE SubName: Full=HLA class II histocompatibility antigen, DM alpha chain {ECO:0000313|Ensembl:ENSP00000378716}; GN Name=HLA-DMA {ECO:0000313|Ensembl:ENSP00000378716}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378716, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000378716, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000378716} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000372715} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645941; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL935042; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX088556; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX664702; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX908719; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759798; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR936913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A2AAT8; -. DR PRIDE; A2AAT8; -. DR Ensembl; ENST00000383228; ENSP00000372715; ENSG00000243215. DR Ensembl; ENST00000395305; ENSP00000378716; ENSG00000204257. DR Ensembl; ENST00000420299; ENSP00000414945; ENSG00000243189. DR Ensembl; ENST00000435503; ENSP00000390001; ENSG00000242685. DR Ensembl; ENST00000451753; ENSP00000409734; ENSG00000242361. DR Ensembl; ENST00000452703; ENSP00000405208; ENSG00000243719. DR Ensembl; ENST00000457285; ENSP00000399032; ENSG00000239463. DR UCSC; uc063nsq.1; human. DR EuPathDB; HostDB:ENSG00000204257.14; -. DR HGNC; HGNC:4934; HLA-DMA. DR OpenTargets; ENSG00000204257; -. DR eggNOG; ENOG410IR26; Eukaryota. DR eggNOG; ENOG410YJDD; LUCA. DR GeneTree; ENSGT00940000161157; -. DR HOGENOM; HOG000231199; -. DR HOVERGEN; HBG001688; -. DR ChiTaRS; HLA-DMA; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204257; Expressed in 207 organ(s), highest expression level in small intestine Peyer's patch. DR ExpressionAtlas; A2AAT8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR Pfam; PF07654; C1-set; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A2AAT8, KW ECO:0000213|PeptideAtlas:A2AAT8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 166 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014565225. FT TRANSMEM 139 159 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 28 120 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 166 AA; 18303 MW; 080802DC0EB61EC5 CRC64; MGHEQNQGAA LLQMLPLLWL LPHSWAVPEG FPIAEVFTLK PLEFGKPNTL VCFVSNLFPP MLTVNWQHHS VPVEGFGPTF VSAVDGLSFQ AFSYLNFTPE PSDIFSCIVT HEIDRYTAIA YWVPRNALPS DLLENVLCGV AFGLGVLGII VGIVLIIYFR KPCSGD //