ID   A2A3E8_HUMAN            Unreviewed;      1932 AA.
AC   A2A3E8;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 98.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000378821};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000378821};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378821, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378821, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000378821}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136245.1; NM_001142773.1.
DR   UniGene; Hs.280209; -.
DR   ProteinModelPortal; A2A3E8; -.
DR   SMR; A2A3E8; -.
DR   MaxQB; A2A3E8; -.
DR   PRIDE; A2A3E8; -.
DR   Ensembl; ENST00000395433; ENSP00000378821; ENSG00000150275.
DR   GeneID; 65217; -.
DR   UCSC; uc057tiq.1; human.
DR   CTD; 65217; -.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   PharmGKB; PA32999; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000156675; -.
DR   HOGENOM; HOG000230919; -.
DR   HOVERGEN; HBG053521; -.
DR   OrthoDB; 21247at2759; -.
DR   ChiTaRS; PCDH15; human.
DR   GenomeRNAi; 65217; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A2A3E8; baseline and differential.
DR   Genevisible; A2A3E8; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 3.
DR   Pfam; PF00028; Cadherin; 8.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 11.
DR   SUPFAM; SSF49313; SSF49313; 10.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3E8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1932       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642399.
FT   TRANSMEM   1354   1377       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    123       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      152    241       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      282    371       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      404    485       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      509    591       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      616    693       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      717    795       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      819    902       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      926   1012       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1033   1120       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1144   1228       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   1932 AA;  213670 MW;  499FDAD2022E67FF CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD GTILVDNMLI KGTAGGPDPT IELSLKDNVD
     YWVLMDPVKQ MLFLNSTGRV LDRDPPMNIH SIVVQVQCIN KKVGTIIYHE VRIVVRDRND
     NSPTFKHESY YATVNELTPV GTTIFTGFSG DNGATDIDDG PNGQIEYVIQ YNPDDPTSND
     TFEIPLMLTG NIVLRKRLNY EDKTRYFVII QANDRAQNLN ERRTTTTTLT VDVLDGDDLG
     PMFLPCVLVP NTRDCRPLTY QAAIPELRTP EELNPIIVTP PIQAIDQDRN IQPPSDRPGI
     LYSILVGTPE DYPRFFHMHP RTAELSLLEP VNRDFHQKFD LVIKAEQDNG HPLPAFAGLH
     IEILDENNQS PYFTMPSYQG YILESAPVGA TISDSLNLTS PLRIVALDKD IEDTKDPELH
     LFLNDYTSVF TVTQTGITRY LTLLQPVDRE EQQTYTFSIT AFDGVQESEP VIVNIQVMDA
     NDNTPTFPEI SYDVYVYTDM RPGDSVIQLT AVDADEGSNG EITYEILVGA QGDFIINKTT
     GLITIAPGVE MIVGRTYALT VQAADNAPPA ERRNSICTVY IEVLPPNNQS PPRFPQLMYS
     LEISEAMRVG AVLLNLQATD REGDSITYAI ENGDPQRVFN LSETTGILTL GKALDRESTD
     RYILIITASD GRPDGTSTAT VNIVVTDVND NAPVFDPYLP RNLSVVEEEA NAFVGQVKAT
     DPDAGINGQV HYSLGNFNNL FRITSNGSIY TAVKLNREVR DYYELVVVAT DGAVHPRHST
     LTLAIKVLDI DDNSPVFTNS TYTVLVEENL PAGTTILQIE AKDVDLGANV SYRIRSPEVK
     HFFALHPFTG ELSLLRSLDY EAFPDQEASI TFLVEAFDIY GTMPPGIATV TVIVKDMNDY
     PPVFSKRIYK GMVAPDAVKG TPITTVYAED ADPPGLPASR VRYRVDDVQF PYPASIFEVE
     EDSGRVITRV NLNEEPTTIF KLVVVAFDDG EPVMSSSATV KILVLHPGEI PRFTQEEYRP
     PPVSELATKG TMVGVISAAA INQSIVYSIV SGNEEDTFGI NNITGVIYVN GPLDYETRTS
     YVLRVQADSL EVVLANLRVP SKSNTAKVYI EIQDENNHPP VFQKKFYIGG VSEDARMFTS
     VLRVKATDKD TGNYSVMAYR LIIPPIKEGK EGFVVETYTG LIKTAMLFHN MRRSYFKFQV
     IATDDYGKGL SGKADVLVSV VNQLDMQVIV SNVPPTLVEK KIEDLTEILD RYVQEQIPGA
     KVVVESIGAR RHGDAFSLED YTKCDLTVYA IDPQTNRAID RNELFKFLDG KLLDINKDFQ
     PYYGEGGRIL EIRTPEAVTS IKKRGESLGY TEGALLALAF IIILCCIPAI LVVLVSYRQR
     QAECTKTARI QAALPAAKPA VPAPAPVAAP PPPPPPPPGA HLYEELGDSS MHNLFLLYHF
     QQSRGNNSVS EDRKHQQVVM PFSSNTIEAH KSAHVDGSLK SNKLKSARKF TFLSDEDDLS
     AHNPLYKENI SQVSTNSDIS QRTDFVDPFS PKIQAKSKSL RGPREKIQRL WSQSVSLPRR
     LMRKVPNRPE IIDLQQWQGT RQKAENENTG ICTNKRGSSN PLLTTEEANL TEKEEIRQGE
     TLMIEGTEQL KSLSSDSSFC FPRPHFSFST LPTVSRTVEL KSEPNVISSP AECSLELSPS
     RPCVLHSSLS RRETPICMLP IETERNIFEN FAHPPNISPS ACPLPPPPPI SPPSPPPAPA
     PLAPPPDISP FSLFCPPPSP PSIPLPLPPP TFFPLSVSTS GPPTPPLLPP FPTPLPPPPP
     SIPCPPPPSA SFLSTECVCI TGVKCTTNLM PAEKIKSSMT QLSTTTVCKT DPQREPKGIL
     RHVKNLAELE KSVANMYSQI EKNYLRTNVS ELQTMCPSEV TNMEITSEQN KGSLNNIVEG
     TEKQSHSQST SL
//