ID   A2A3C6_HUMAN            Unreviewed;      1500 AA.
AC   A2A3C6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 104.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSP00000381564};
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSP00000381564};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381564, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381564, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381564}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
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DR   EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A3C6; -.
DR   jPOST; A2A3C6; -.
DR   PeptideAtlas; A2A3C6; -.
DR   PRIDE; A2A3C6; -.
DR   Ensembl; ENST00000398556; ENSP00000381564; ENSG00000121753.
DR   UCSC; uc010ogn.3; human.
DR   EuPathDB; HostDB:ENSG00000121753.12; -.
DR   HGNC; HGNC:944; ADGRB2.
DR   OpenTargets; ENSG00000121753; -.
DR   GeneTree; ENSGT00940000160103; -.
DR   HOGENOM; HOG000230916; -.
DR   HOVERGEN; HBG004813; -.
DR   ChiTaRS; ADGRB2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000121753; Expressed in 145 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A2A3C6; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3C6};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36   1500       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002641821.
FT   TRANSMEM    884    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    917    938       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    950    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    986   1004       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1024   1047       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1068   1090       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      469    539       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      819    871       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      880   1121       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   1500 AA;  163786 MW;  21AC1532E02883AA CRC64;
     MLSLRGPDTH GKGHRMTPAC PLLLSVILSL RLATAFDPAP SACSALASGV LYGAFSLQDL
     FPTIASGCSW TLENPDPTKY SLYLRFNRQE QVCAHFAPRL LPLDHYLVNF TCLRPSPEEA
     VAQAESEVGR PEEEEAEAAA GLELCSGSGP FTFLHFDKNF VQLCLSAEPS EAPRLLAPAA
     LAFRFVEVLL INNNNSSQFT CGVLCRWSEE CGRAAGRACG FAQPGCSCPG EAGAGSTTTT
     SPGPPAAHTL SNALVPGGPA PPAEADLHSG SSNDLFTTEM RYGEEPEEEP KVKTQWPRSA
     DEPGLYMAQT VHGVWEEWGS WSLCSRSCGR GSRSRMRTCV PPQHGGKACE GPELQTKLCS
     MAACPVEGQW LEWGPWGPCS TSCANGTQQR SRKCSVAGPA WATCTGALTD TRECSNLECP
     ATDSKWGPWN AWSLCSKTCD TGWQRRFRMC QATGTQGYPC EGTGEEVKPC SEKRCPAFHE
     MCRDEYVMLM TWKKAAAGEI IYNKCPPNAS GSASRRCLLS AQGVAYWGLP SFARCISHEY
     RYLYLSLREH LAKGQRMLAG EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR
     ATYVPSADDV QRFFQVVSFM VDAENKEKWD DAQQVSPGSV HLLRVVEDFI HLVGDALKAF
     QSSLIVTDNL VISIQREPVS AVSSDITFPM RGRRGMKDWV RHSEDRLFLP KEVLSLSSPG
     KPATSGAAGS PGRGRGPGTV PPGPGHSHQR LLPADPDESS YFVIGAVLYR TLGLILPPPR
     PPLAVTSRVM TVTVRPPTQP PAEPLITVEL SYIINGTTDP HCASWDYSRA DASSGDWDTE
     NCQTLETQAA HTRCQCQHLS TFAVLAQPPK DLTLELAGSP SVPLVIGCAV SCMALLTLLA
     IYAAFWRFIK SERSIILLNF CLSILASNIL ILVGQSRVLS KGVCTMTAAF LHFFFLSSFC
     WVLTEAWQSY LAVIGRMRTR LVRKRFLCLG WGLPALVVAV SVGFTRTKGY GTSSYCWLSL
     EGGLLYAFVG PAAVIVLVNM LIGIIVFNKL MARDGISDKS KKQRAGASLW SSCVVLPLLA
     LTWMSAVLAM TDRRSVLFQA LFAVFNSAQG FVITAVHCFL RREVQDVVKC QMGVCRADES
     EDSPDSCKNG QLQILSDFEK DVDLACQTVL FKEVNTCNPS TITGTLSRLS LDEDEEPKSC
     LVGPEGSLSF SPLPGNILVP MAASPGLGEP PPPQEANPVY MCGEGGLRQL DLTWLRPTEP
     GSEGDYMVLP RRTLSLQPGG GGGGGEDAPR ARPEGTPRRA AKTVAHTEGY PSFLSVDHSG
     LGLGPAYGSL QNPYGMTFQP PPPTPSARQV PEPGERSRTM PRTVPGSTMK MGSLERKKLR
     YSDLDFEKVM HTRKRHSELY HELNQKFHTF DRYRSQSTAK REKRWSVSSG GAAERSVCTD
     KPSPGERPSL SQHRRHQSWS TFKSMTLGSL PPKPRERLTL HRAAAWEPTE PPDGDFQTEV
//