ID   A2A3C4_HUMAN            Unreviewed;       847 AA.
AC   A2A3C4;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 96.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSP00000410921};
DE   Flags: Fragment;
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSP00000410921};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410921, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000410921, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000410921}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A3C4; -.
DR   jPOST; A2A3C4; -.
DR   PeptideAtlas; A2A3C4; -.
DR   PRIDE; A2A3C4; -.
DR   Ensembl; ENST00000420125; ENSP00000410921; ENSG00000121753.
DR   UCSC; uc057egq.1; human.
DR   EuPathDB; HostDB:ENSG00000121753.12; -.
DR   HGNC; HGNC:944; ADGRB2.
DR   OpenTargets; ENSG00000121753; -.
DR   GeneTree; ENSGT00940000160103; -.
DR   HOGENOM; HOG000230916; -.
DR   HOVERGEN; HBG004813; -.
DR   ChiTaRS; ADGRB2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000121753; Expressed in 145 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A2A3C4; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3C4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    847       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642395.
FT   DOMAIN      459    529       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      809    847       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000410921}.
FT   NON_TER     847    847       {ECO:0000313|Ensembl:ENSP00000410921}.
SQ   SEQUENCE   847 AA;  92030 MW;  528373746F2AED21 CRC64;
     GKGHRMTPAC PLLLSVILSL RLATAFDPAP SACSALASGV LYGAFSLQDL FPTIASGCSW
     TLENPDPTKY SLYLRFNRQE QVCAHFAPRL LPLDHYLVNF TCLRPSPEEA VAQAESEVGR
     PEEEEAEAAA GLELCSGSGP FTFLHFDKNF VQLCLSAEPS EAPRLLAPAA LAFRFVEVLL
     INNNNSSQFT CGVLCRWSEE CGRAAGRACG FAQPGCSCPG EAGAGSTTTT SPGPPAAHTL
     SNALVPGGPA PPAEADLHSG SSNDLFTTEM RYGEEPEEEP KVKTQWPRSA DEPGLYMAQT
     GDPAAEEWSP WSVCSLTCGQ GLQVRTRSCV SSPYGTLCSG PLRETRPCNN SATCPVEGQW
     LEWGPWGPCS TSCANGTQQR SRKCSVAGPA WATCTGALTD TRECSNLECP ATDSKWGPWN
     AWSLCSKTCD TGWQRRFRMC QATGTQGYPC EGTGEEVKPC SEKRCPAFHE MCRDEYVMLM
     TWKKAAAGEI IYNKCPPNAS GSASRRCLLS AQGVAYWGLP SFARCISHEY RYLYLSLREH
     LAKGQRMLAG EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR ATYVPSADDV
     QRFFQVVSFM VDAENKEKWD DAQQVSPGSV HLLRVVEDFI HLVGDALKAF QSSLIVTDNL
     VISIQREPVS AVSSDITFPM RGRRGMKDWV RHSEDRLFLP KEVLSLSSPG KPATSGAAGS
     PGRGRGPGTV PPGPGHSHQR LLPADPDESS YFVIGAVLYR TLGLILPPPR PPLAVTSRVM
     TVTVRPPTQP PAEPLITVEL SYIINGTTDP HCASWDYSRA DASSGDWDTE NCQTLETQAA
     HTRCQCQ
//