ID   A2A3C3_HUMAN            Unreviewed;      1499 AA.
AC   A2A3C3;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 101.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSP00000381555};
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSP00000381555};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381555, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381555, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381555}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
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DR   EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A3C3; -.
DR   jPOST; A2A3C3; -.
DR   PeptideAtlas; A2A3C3; -.
DR   PRIDE; A2A3C3; -.
DR   Ensembl; ENST00000398547; ENSP00000381555; ENSG00000121753.
DR   UCSC; uc057egm.1; human.
DR   EuPathDB; HostDB:ENSG00000121753.12; -.
DR   HGNC; HGNC:944; ADGRB2.
DR   OpenTargets; ENSG00000121753; -.
DR   GeneTree; ENSGT00940000160103; -.
DR   HOGENOM; HOG000230916; -.
DR   HOVERGEN; HBG004813; -.
DR   ChiTaRS; ADGRB2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000121753; Expressed in 145 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A2A3C3; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3C3};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1499       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642599.
FT   TRANSMEM    869    890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    902    923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    935    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1036       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1057   1075       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1087   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1114   1134       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      454    524       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      804    856       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      865   1139       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   1499 AA;  163423 MW;  66FFE1CB43C370FD CRC64;
     MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
     DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SPEEAVAQAE SEVGRPEEEE
     AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
     SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAG STTTTSPGPP AAHTLSNALV
     PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTVHGVW
     EEWGSWSLCS RSCGRGSRSR MRTCVPPQHG GKACEGPELQ TKLCSMAACP VEGQWLEWGP
     WGPCSTSCAN GTQQRSRKCS VAGPAWATCT GALTDTRECS NLECPATDSK WGPWNAWSLC
     SKTCDTGWQR RFRMCQATGT QGYPCEGTGE EVKPCSEKRC PAFHEMCRDE YVMLMTWKKA
     AAGEIIYNKC PPNASGSASR RCLLSAQGVA YWGLPSFARC ISHEYRYLYL SLREHLAKGQ
     RMLAGEGMSQ VVRSLQELLA RRTYYSGDLL FSVDILRNVT DTFKRATYVP SADDVQRFFQ
     VVSFMVDAEN KEKWDDAQQV SPGSVHLLRV VEDFIHLVGD ALKAFQSSLI VTDNLVISIQ
     REPVSAVSSD ITFPMRGRRG MKDWVRHSED RLFLPKEVLS LSSPGKPATS GAAGSPGRGR
     GPGTVPPGPG HSHQRLLPAD PDESSYFVIG AVLYRTLGLI LPPPRPPLAV TSRVMTVTVR
     PPTQPPAEPL ITVELSYIIN GTTDPHCASW DYSRADASSG DWDTENCQTL ETQAAHTRCQ
     CQHLSTFAVL AQPPKDLTLE LAGSPSVPLV IGCAVSCMAL LTLLAIYAAF WRFIKSERSI
     ILLNFCLSIL ASNILILVGQ SRVLSKGVCT MTAAFLHFFF LSSFCWVLTE AWQSYLAVIG
     RMRTRLVRKR FLCLGWGLPA LVVAVSVGFT RTKGYGTSSY CWLSLEGGLL YAFVGPAAVI
     VLVNMLIGII VFNKLMARDG ISDKSKKQRA GSERCPWASL LLPCSACGAV PSPLLSSASA
     RNAMASLWSS CVVLPLLALT WMSAVLAMTD RRSVLFQALF AVFNSAQGFV ITAVHCFLRR
     EVQDVVKCQM GVCRADESED SPDSCKNGQL QILSDFEKDV DLACQTVLFK EVNTCNPSTI
     TGTLSRLSLD EDEEPKSCLV GPEGSLSFSP LPGNILVPMA ASPGLGEPPP PQEANPVYMC
     GEGGLRQLDL TWLRPTEPGS EGDYMVLPRR TLSLQPGGGG GGGEDAPRAR PEGTPRRAAK
     TVAHTEGYPS FLSVDHSGLG LGPAYGSLQN PYGMTFQPPP PTPSARQVPE PGERSRTMPR
     TVPGSTMKMG SLERKKLRYS DLDFEKVMHT RKRHSELYHE LNQKFHTFDR YRSQSTAKDK
     PSPGERPSLS QHRRHQSWST FKSMTLGSLP PKPRERLTLH RAAAWEPTEP PDGDFQTEV
//