ID   A2A3C2_HUMAN            Unreviewed;      1554 AA.
AC   A2A3C2;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 102.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSP00000381548};
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSP00000381548};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381548, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381548, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381548}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
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DR   EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A3C2; -.
DR   jPOST; A2A3C2; -.
DR   PeptideAtlas; A2A3C2; -.
DR   PRIDE; A2A3C2; -.
DR   Ensembl; ENST00000398538; ENSP00000381548; ENSG00000121753.
DR   UCSC; uc057ego.1; human.
DR   EuPathDB; HostDB:ENSG00000121753.12; -.
DR   HGNC; HGNC:944; ADGRB2.
DR   OpenTargets; ENSG00000121753; -.
DR   eggNOG; ENOG410IEA0; Eukaryota.
DR   eggNOG; ENOG4111FBM; LUCA.
DR   GeneTree; ENSGT00940000160103; -.
DR   HOGENOM; HOG000230916; -.
DR   HOVERGEN; HBG004813; -.
DR   ChiTaRS; ADGRB2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000121753; Expressed in 145 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A2A3C2; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 4.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF00090; TSP_1; 4.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 4.
DR   SUPFAM; SSF82895; SSF82895; 4.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3C2};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1554       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642611.
FT   TRANSMEM    924    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    957    978       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    990   1014       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1026   1044       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1064   1091       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1142   1162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1169   1189       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      509    579       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      859    911       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      920   1194       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   1554 AA;  169222 MW;  61C391B8D722EF95 CRC64;
     MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
     DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SPEEAVAQAE SEVGRPEEEE
     AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
     SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAG STTTTSPGPP AAHTLSNALV
     PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA
     EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP VHGVWEEWGS
     WSLCSRSCGR GSRSRMRTCV PPQHGGKACE GPELQTKLCS MAACPVEGQW LEWGPWGPCS
     TSCANGTQQR SRKCSVAGPA WATCTGALTD TRECSNLECP ATDSKWGPWN AWSLCSKTCD
     TGWQRRFRMC QATGTQGYPC EGTGEEVKPC SEKRCPAFHE MCRDEYVMLM TWKKAAAGEI
     IYNKCPPNAS GSASRRCLLS AQGVAYWGLP SFARCISHEY RYLYLSLREH LAKGQRMLAG
     EGMSQVVRSL QELLARRTYY SGDLLFSVDI LRNVTDTFKR ATYVPSADDV QRFFQVVSFM
     VDAENKEKWD DAQQVSPGSV HLLRVVEDFI HLVGDALKAF QSSLIVTDNL VISIQREPVS
     AVSSDITFPM RGRRGMKDWV RHSEDRLFLP KEVLSLSSPG KPATSGAAGS PGRGRGPGTV
     PPGPGHSHQR LLPADPDESS YFVIGAVLYR TLGLILPPPR PPLAVTSRVM TVTVRPPTQP
     PAEPLITVEL SYIINGTTDP HCASWDYSRA DASSGDWDTE NCQTLETQAA HTRCQCQHLS
     TFAVLAQPPK DLTLELAGSP SVPLVIGCAV SCMALLTLLA IYAAFWRFIK SERSIILLNF
     CLSILASNIL ILVGQSRVLS KGVCTMTAAF LHFFFLSSFC WVLTEAWQSY LAVIGRMRTR
     LVRKRFLCLG WGLPALVVAV SVGFTRTKGY GTSSYCWLSL EGGLLYAFVG PAAVIVLVNM
     LIGIIVFNKL MARDGISDKS KKQRAGSERC PWASLLLPCS ACGAVPSPLL SSASARNAMA
     SLWSSCVVLP LLALTWMSAV LAMTDRRSVL FQALFAVFNS AQGFVITAVH CFLRREVQDV
     VKCQMGVCRA DESEDSPDSC KNGQLQILSD FEKDVDLACQ TVLFKEVNTC NPSTITGTLS
     RLSLDEDEEP KSCLVGPEGS LSFSPLPGNI LVPMAASPGL GEPPPPQEAN PVYMCGEGGL
     RQLDLTWLRP TEPGSEGDYM VLPRRTLSLQ PGGGGGGGED APRARPEGTP RRAAKTVAHT
     EGYPSFLSVD HSGLGLGPAY GSLQNPYGMT FQPPPPTPSA RQVPEPGERS RTMPRTVPGS
     TMKMGSLERK KLRYSDLDFE KVMHTRKRHS ELYHELNQKF HTFDRYRSQS TAKDKPSPGE
     RPSLSQHRRH QSWSTFKSMT LGSLPPKPRE RLTLHRAAAW EPTEPPDGDF QTEV
//