ID   A2A3C1_HUMAN            Unreviewed;      1466 AA.
AC   A2A3C1;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 105.
DE   SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSP00000381550};
GN   Name=ADGRB2 {ECO:0000313|Ensembl:ENSP00000381550};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381550, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381550, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381550}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
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DR   EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A3C1; -.
DR   jPOST; A2A3C1; -.
DR   PeptideAtlas; A2A3C1; -.
DR   PRIDE; A2A3C1; -.
DR   Ensembl; ENST00000398542; ENSP00000381550; ENSG00000121753.
DR   UCSC; uc001btq.2; human.
DR   EuPathDB; HostDB:ENSG00000121753.12; -.
DR   HGNC; HGNC:944; ADGRB2.
DR   OpenTargets; ENSG00000121753; -.
DR   GeneTree; ENSGT00940000160103; -.
DR   HOGENOM; HOG000230916; -.
DR   HOVERGEN; HBG004813; -.
DR   ChiTaRS; ADGRB2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000121753; Expressed in 145 organ(s), highest expression level in right frontal lobe.
DR   ExpressionAtlas; A2A3C1; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A2A3C1};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1466       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642147.
FT   TRANSMEM    869    890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    902    923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    935    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1032       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1053   1075       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      454    524       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      804    856       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      865   1106       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   1466 AA;  159919 MW;  81A274A2559D0E9B CRC64;
     MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
     DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SPEEAVAQAE SEVGRPEEEE
     AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
     SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAG STTTTSPGPP AAHTLSNALV
     PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA
     EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP VEGQWLEWGP
     WGPCSTSCAN GTQQRSRKCS VAGPAWATCT GALTDTRECS NLECPATDSK WGPWNAWSLC
     SKTCDTGWQR RFRMCQATGT QGYPCEGTGE EVKPCSEKRC PAFHEMCRDE YVMLMTWKKA
     AAGEIIYNKC PPNASGSASR RCLLSAQGVA YWGLPSFARC ISHEYRYLYL SLREHLAKGQ
     RMLAGEGMSQ VVRSLQELLA RRTYYSGDLL FSVDILRNVT DTFKRATYVP SADDVQRFFQ
     VVSFMVDAEN KEKWDDAQQV SPGSVHLLRV VEDFIHLVGD ALKAFQSSLI VTDNLVISIQ
     REPVSAVSSD ITFPMRGRRG MKDWVRHSED RLFLPKEVLS LSSPGKPATS GAAGSPGRGR
     GPGTVPPGPG HSHQRLLPAD PDESSYFVIG AVLYRTLGLI LPPPRPPLAV TSRVMTVTVR
     PPTQPPAEPL ITVELSYIIN GTTDPHCASW DYSRADASSG DWDTENCQTL ETQAAHTRCQ
     CQHLSTFAVL AQPPKDLTLE LAGSPSVPLV IGCAVSCMAL LTLLAIYAAF WRFIKSERSI
     ILLNFCLSIL ASNILILVGQ SRVLSKGVCT MTAAFLHFFF LSSFCWVLTE AWQSYLAVIG
     RMRTRLVRKR FLCLGWGLPA LVVAVSVGFT RTKGYGTSSY CWLSLEGGLL YAFVGPAAVI
     VLVNMLIGII VFNKLMARDG ISDKSKKQRA GASLWSSCVV LPLLALTWMS AVLAMTDRRS
     VLFQALFAVF NSAQGFVITA VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL
     SDFEKDVDLA CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
     NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS
     LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG
     MTFQPPPPTP SARQVPEPGE RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR
     HSELYHELNQ KFHTFDRYRS QSTAKDKPSP GERPSLSQHR RHQSWSTFKS MTLGSLPPKP
     RERLTLHRAA AWEPTEPPDG DFQTEV
//