ID   A2A343_HUMAN            Unreviewed;       275 AA.
AC   A2A343;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   05-DEC-2018, entry version 76.
DE   SubName: Full=ADAMTS-like protein 1 {ECO:0000313|Ensembl:ENSP00000373362};
GN   Name=ADAMTSL1 {ECO:0000313|Ensembl:ENSP00000373362};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373362, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000373362, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000373362}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL353895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL442638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL445674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL449963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL450004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL513502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL513503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL591423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL645565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A343; -.
DR   PeptideAtlas; A2A343; -.
DR   PRIDE; A2A343; -.
DR   Ensembl; ENST00000388710; ENSP00000373362; ENSG00000178031.
DR   UCSC; uc064shb.1; human.
DR   EuPathDB; HostDB:ENSG00000178031.15; -.
DR   HGNC; HGNC:14632; ADAMTSL1.
DR   OpenTargets; ENSG00000178031; -.
DR   GeneTree; ENSGT00940000156243; -.
DR   HOGENOM; HOG000230905; -.
DR   ChiTaRS; ADAMTSL1; human.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000178031; Expressed in 141 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; A2A343; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A2A343,
KW   ECO:0000213|PeptideAtlas:A2A343};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    275       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642598.
FT   DOMAIN        1     70       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN       96    186       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   275 AA;  29391 MW;  E3116ED006A5D10C CRC64;
     MSGVFCFFFF FLGVPEAEVT WFRNKSKLGS PHHLHEGSLL LTNVSSSDQG LYSCRAANLH
     GELTESTQLL ILDPPQVPTQ LEDIRALLAA TGPNLPSVLT SPLGTQLVLD PGNSALLGCP
     IKGHPVPNIT WFHGGQPIVT ATGLTHHILA AGQILQVANL SGGSQGEFSC LAQNEAGVLM
     QKASLVIQVQ WALHRASPSC ATQTSLLPDT GWHHLTIRAV QCSSEACEHP ELLVRGLQCT
     LESQPVDPVH SYLWQLRLPV PACGVCACPH QQGSA
//