ID   A2A2R0_HUMAN            Unreviewed;       147 AA.
AC   A2A2R0;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 83.
DE   SubName: Full=BPI fold-containing family B member 1 {ECO:0000313|Ensembl:ENSP00000390471};
DE   Flags: Fragment;
GN   Name=BPIFB1 {ECO:0000313|Ensembl:ENSP00000390471};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390471, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000390471, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000390471}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL121901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A2A2R0; -.
DR   jPOST; A2A2R0; -.
DR   PeptideAtlas; A2A2R0; -.
DR   PRIDE; A2A2R0; -.
DR   Ensembl; ENST00000423645; ENSP00000390471; ENSG00000125999.
DR   UCSC; uc061wfz.1; human.
DR   EuPathDB; HostDB:ENSG00000125999.10; -.
DR   HGNC; HGNC:16108; BPIFB1.
DR   OpenTargets; ENSG00000125999; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   eggNOG; ENOG410Z88E; LUCA.
DR   GeneTree; ENSGT00940000153099; -.
DR   ChiTaRS; BPIFB1; human.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000125999; Expressed in 52 organ(s), highest expression level in lung.
DR   ExpressionAtlas; A2A2R0; baseline and differential.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR032942; BPI/LBP/Plunc.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR10504; PTHR10504; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A2A2R0,
KW   ECO:0000213|PeptideAtlas:A2A2R0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    147       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002642597.
FT   DOMAIN       44    146       BPI1. {ECO:0000259|Pfam:PF01273}.
FT   NON_TER     147    147       {ECO:0000313|Ensembl:ENSP00000390471}.
SQ   SEQUENCE   147 AA;  15899 MW;  0E4C58A2369927FF CRC64;
     MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS
     AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF
     NTPLVKTIVE FHMTTEAQAT IRMDTSA
//